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Chka
Gene Detail
 Symbol
Name
ID
Chka
choline kinase alpha
MGI:107760
Synonyms Chk, ChoK, choline/ethanolamine kinase alpha, CK/EK-alpha, EtnK-alpha
Feature Type protein coding gene
Genetic Map
Chromosome 19
3.57 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:3851773-3894369 bp, + strand
From VEGA annotation of GRCm38

  42597 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88575  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Chka

Human
homologs
Human Homolog CHKA, choline kinase alpha
NCBI Gene ID 1119
neXtProt AC  NX_P35790
Human Synonyms  CHK, CK, CKI, EK
Human Chr (Location)  11q13.2; chr11:68052859-68121391 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(12) Targeted(2)
Incidental mutations (data from APF )
 
Mice homozygous for a null allele exhibit embryonic lethality between E3.5 and E7.5.
 
Interactions
Chka interacts with 294 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process CDP-choline pathway, choline metabolic process, ...
Component cytoplasm
Function ATP binding, choline binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (112)    Tissues (108)    Images (6)
Theiler Stages: 20, 22, 24, 26, 28
Assay TypeResults
RNA in situ 112
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(12) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029650 (Evidence)
Ensembl Gene ModelENSMUSG00000024843 (Evidence)
Entrez Gene12660 (Evidence)
NIA Mouse Gene IndexU019111, U038765
EC2.7.1.82, 2.7.1.32
Consensus CDS ProjectCCDS29400.1, CCDS70913.1
International Mouse Knockout Project StatusChka
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029650 VEGA Gene Model | MGI Sequence Detail 42597 C57BL/6J ±  kb
transcript OTTMUST00000073551 VEGA | MGI Sequence Detail 2319 Not Applicable 
polypeptide OTTMUSP00000038092 VEGA | MGI Sequence Detail 453 Not Applicable 

For the selected sequences
All sequences(101) RefSeq(19) UniProt(8)
Polymorphisms SNPs within 2kb(164 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR011009 Protein kinase-like domain
Protein Ontology PR:000005427 choline kinase alpha
References (Earliest) J:44483 Brady KP, et al., Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis. Genome Res. 1997 Nov;7(11):1085-93
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(44)
Other
accession IDs
MGD-MRK-36336

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory