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Gfer
Gene Detail
Symbol

Name
ID
Gfer
growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration)
MGI:107757
Synonyms
Alr, ERV1
Feature Type
protein coding gene
Genetic Map
Chromosome 17
12.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr17:24693191-24696156 bp, - strand
From Ensembl annotation of GRCm38

  2966 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GFER
Protein SuperFamily: mitochondrial sulfhydryl oxidase Erv1p/ALR
Gene Tree: Gfer

Human
homologs
GFER, growth factor, augmenter of liver regeneration
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2671
neXtProt AC: NX_P55789

Human Synonyms: ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS

Human Chr (Location): 16p13.3-p13.12; chr16:1984149-1987749 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GFER

Mutations,
alleles, and
phenotypes
All mutations/alleles(15) : Gene trapped(13) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Gfer interacts with 114 markers (Mir23a, Mir23b, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process liver regeneration, negative regulation of apoptotic process, ...
Component cytoplasm, cytosol, ...
Function flavin adenine dinucleotide binding, flavin-linked sulfhydryl oxidase activity, ...
External Resources: FuncBase
Expression
cDNA source data(70)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN gfer    NEW 
Molecular
reagents
All nucleic(74) Genomic(3) cDNA(70) Other(1)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000040888 (Evidence)
Entrez Gene 11692 (Evidence)
UniGene 28124
DFCI TC1579158, TC1587206
DoTS DT.101169685, DT.101409956, DT.94333531
NIA Mouse Gene Index U037533
EC 1.8.3.2
Consensus CDS Project CCDS28492.1
International Mouse Phenotyping Consortium Status Gfer
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040888 Ensembl Gene Model | MGI Sequence Detail 2966 C57BL/6J ±  kb
transcript ENSMUST00000046839 Ensembl | MGI Sequence Detail 1775 Not Applicable 
polypeptide ENSMUSP00000049186 Ensembl | MGI Sequence Detail 198 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(7) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(42 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017905 ERV/ALR sulfhydryl oxidase domain
Protein Ontology PR:000007940 FAD-linked sulfhydryl oxidase ALR
References
(Earliest) J:35860 Giorda R, et al., Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 1996 Jan;2(1):97-108
(Latest) J:182992 Teng EC, et al., Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells. Mol Biol Cell. 2011 Apr 15;22(8):1312-20
All references(35)
Other
accession IDs
MGD-MRK-36333

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory