Gfer
Gene Detail

Symbol Name ID

Gfer growth factor, erv1 (S. cerevisiae)-like (augmenter of liver regeneration) MGI:107757

Synonyms

Alr, ERV1

Feature Type

protein coding gene

Genetic Map

Chromosome 17

12.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr17:24693191-24696156 bp, - strand From NCBI annotation of GRCm38   2966 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55884  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: mitochondrial sulfhydryl oxidase Erv1p/ALR
Gene Tree: Gfer

Human homologs

Human Homolog		GFER, growth factor, augmenter of liver regeneration
NCBI Gene ID		2671
neXtProt AC		NX_P55789
Human Synonyms		ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS
Human Chr (Location)		16p13.3-p13.12; chr16:2034150-2037749 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GFER

Alleles and phenotypes

All alleles(14) : Targeted(1) Gene trapped(13)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	oxidation-reduction process
Component	cytoplasm, mitochondrion
Function	flavin adenine dinucleotide binding, growth factor activity, ...

External Resources: FuncBase

Expression

cDNA source data(70)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(74) Genomic(3) cDNA(70) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000040888 (Evidence)
Entrez Gene	11692 (Evidence)
UniGene	28124
DFCI	TC1579158, TC1587206
DoTS	DT.101169685, DT.101409956, DT.94333531
NIA Mouse Gene Index	U037533
EC	1.8.3.2
Consensus CDS Project	CCDS28492.1
International Mouse Knockout Project Status	Gfer

Sequences

Length	Strain/Species
genomic	11692	NCBI Gene Model | MGI Sequence Detail	2966	C57BL/6J
transcript	NM_023040	RefSeq | MGI Sequence Detail	1775	C57BL/6
polypeptide	P56213	UniProt | EBI | MGI Sequence Detail	198	Not Applicable

All sequences(29) RefSeq(3) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(13 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR006863	Erv1/Alr
InterPro	IPR017905	ERV/ALR sulphydryl oxidase
Protein Ontology	PR:000007940	FAD-linked sulfhydryl oxidase ALR

Graphical View of Protein Domain Structure

References

(Earliest) J:35860 Giorda R, et al., Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 1996 Jan;2(1):97-108
(Latest) J:182992 Teng EC, et al., Gfer inhibits Jab1-mediated degradation of p27kip1 to restrict proliferation of hematopoietic stem cells. Mol Biol Cell. 2011 Apr 15;22(8):1312-20
All references(34)

Other accession IDs

MGD-MRK-36333