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Gfer Gene Detail
Summary
  • Symbol
    Gfer
  • Name
    growth factor, augmenter of liver regeneration
  • Synonyms
    Alr, ERV1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107757
    NCBI Gene: 11692
  • Gene Overview
    MyGene.info: GFER
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:24693191-24696156 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 12.48 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    44 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107757
protein coding gene Chr17:24693189-24696228 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023314
protein coding gene Chr17:23704504-23706907 (-)
A/J MGP_AJ_G0023274
protein coding gene Chr17:23057519-23059922 (-)
AKR/J MGP_AKRJ_G0023241
protein coding gene Chr17:23136980-23139395 (-)
BALB/cJ MGP_BALBcJ_G0023279
protein coding gene Chr17:23243797-23246210 (-)
C3H/HeJ MGP_C3HHeJ_G0023039
protein coding gene Chr17:23497803-23500219 (-)
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0021197
protein coding gene Chr17:20528825-20531357 (-)
CAST/EiJ MGP_CASTEiJ_G0022541
protein coding gene Chr17:23348468-23352140 (-)
CBA/J MGP_CBAJ_G0023015
protein coding gene Chr17:25603961-25606377 (-)
DBA/2J MGP_DBA2J_G0023144
protein coding gene Chr17:22650667-22653070 (-)
FVB/NJ MGP_FVBNJ_G0023114
protein coding gene Chr17:22368021-22370484 (-)
LP/J MGP_LPJ_G0023221
protein coding gene Chr17:24010944-24013347 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023133
protein coding gene Chr17:25301951-25304354 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023760
protein coding gene Chr17:23419555-23421958 (-)
PWK/PhJ MGP_PWKPhJ_G0022290
protein coding gene Chr17:21392743-21395287 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022108
protein coding gene Chr17:21459484-21461935 (-)
WSB/EiJ MGP_WSBEiJ_G0022604
protein coding gene Chr17:23487039-23489451 (-)



Homology
more
  • Human Ortholog
    GFER, growth factor, augmenter of liver regeneration
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GFER, growth factor, augmenter of liver regeneration
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS
  • Links
    NCBI Gene ID: 2671
    neXtProt AC: NX_P55789
    UniProt: P55789

  • Chr Location
    16p13.3; chr16:1984149-1987749 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    36 phenotypes from 3 alleles in 4 genetic backgrounds
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic lethality before E9.5. Mice homozygous for a different knock-out allele are embryonic lethal, while heterozygotes display impaired mitochondrial biogenesis and decreased liver degeneration following partial hepatectomy or acute liver injury.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000040888 Ensembl Gene Model | MGI Sequence Detail 2966 C57BL/6J ±  kb
transcript ENSMUST00000046839 Ensembl | MGI Sequence Detail 1775 Not Applicable  
polypeptide ENSMUSP00000049186 Ensembl | MGI Sequence Detail 198 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 75
    Genomic 4
    cDNA 70
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36333
References
more
  • Summaries
    All 39
    Gene Ontology 9
    Phenotypes 8
  • Earliest
    J:35860 Giorda R, et al., Analysis of the structure and expression of the augmenter of liver regeneration (ALR) gene. Mol Med. 1996 Jan;2(1):97-108
  • Latest
    J:251719 Kumar S, et al., Hepatic Deficiency of Augmenter of Liver Regeneration Exacerbates Alcohol-Induced Liver Injury and Promotes Fibrosis in Mice. PLoS One. 2016;11(1):e0147864

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory