Neurog1
Gene Detail

Symbol Name ID

Neurog1 neurogenin 1 MGI:107754

Synonyms

bHLHa6, Math4C, Neurod3, neurogenin, neurogenin 1, ngn1

Feature Type

protein coding gene

Genetic Map

Chromosome 13

30.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr13:56250505-56252163 bp, - strand From Ensembl annotation of GRCm38   1659 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:4490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Neurog1

Human homologs

Human Homolog		NEUROG1, neurogenin 1
NCBI Gene ID		4762
neXtProt AC		NX_Q92886
Human Synonyms		AKA, bHLHa6, Math4C, NEUROD3, ngn1
Human Chr (Location)		5q23-q31; chr5:134869972-134871639 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygotes for a targeted null mutation exhibit defects in midbrain, dorsal root sensory ganglia and a subset of cranial ganglia. Mutants are born alive, but fail to nurse, and die within 12 hours.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cell differentiation, cell fate commitment, ...
Component	neuronal cell body, nucleus, ...
Function	chromatin binding, DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (141 records)
Data Summary: Results (389)    Tissues (209)    Images (64)
Theiler Stages: 5, 13, 14, 15, 17, 18, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	369
Northern blot	11
Western blot	1
RT-PCR	8

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(32) Genomic(6) cDNA(14) Primer pair(7) Other(5)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000048904 (Evidence)
Entrez Gene	18014 (Evidence)
UniGene	266665
DFCI	TC1586769
DoTS	DT.40168057
NIA Mouse Gene Index	U034830
Consensus CDS Project	CCDS26559.1
International Mouse Knockout Project Status	Neurog1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000048904	Ensembl Gene Model | MGI Sequence Detail	1659	C57BL/6J
transcript	ENSMUST00000058475	Ensembl | MGI Sequence Detail	1659	Not Applicable
polypeptide	ENSMUSP00000050484	Ensembl | MGI Sequence Detail	244	Not Applicable

All sequences(14) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(2 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR011598	Helix-loop-helix domain
Protein Ontology	PR:000011156	neurogenin-1

References

(Earliest) J:35346 McCormick MB, et al., NeuroD2 and neuroD3: distinct expression patterns and transcriptional activation potentials within the neuroD gene family. Mol Cell Biol. 1996 Oct;16(10):5792-800
(Latest) J:193024 Velkey JM, et al., Expression of Neurogenin 1 in Mouse Embryonic Stem Cells Directs the Differentiation of Neuronal Precursors and Identifies Unique Patterns of Down-stream Gene Expression. Dev Dyn. 2013 Mar;242(3):230-53
All references(190)

Other accession IDs

MGD-MRK-36330