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Neurog1 Gene Detail
Summary
  • Symbol
    Neurog1
  • Name
    neurogenin 1
  • Synonyms
    bHLHa6, Math4C, Neurod3, neurogenin, neurogenin 1, ngn1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107754
    NCBI Gene: 18014
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:56398291-56399976 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 30.06 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    113 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107754
 protein coding gene Chr13:56398291-56399993 (-)
129S1/SvImJ ENSMUSG00200016659
 protein coding gene Chr13:53274617-53276302 (-)
A/J ENSMUSG00195039514
 protein coding gene Chr13:52742270-52743958 (-)
AKR/J ENSMUSG00220034585
 protein coding gene Chr13:52278910-52280596 (-)
BALB/cJ ENSMUSG00180016279
 protein coding gene Chr13:52987983-52989670 (-)
C3H/HeJ ENSMUSG00175040450
 protein coding gene Chr13:52774205-52775890 (-)
C57BL/6NJ ENSMUSG00215031669
 protein coding gene Chr13:52800987-52802673 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018581
 protein coding gene Chr13:51648364-51650024 (-)
CAST/EiJ ENSTCUG00005038565
 protein coding gene Chr13:53185683-53187376 (-)
CBA/J ENSMUSG00210030814
 protein coding gene Chr13:52979163-52980848 (-)
DBA/2J ENSMUSG00185014419
 protein coding gene Chr13:53825891-53827576 (-)
FVB/NJ ENSMUSG00205041910
 protein coding gene Chr13:52625514-52627200 (-)
JF1/MsJ ENSUMUG00000030816
 protein coding gene Chr13:53226105-53227794 (-)
LP/J ENSMUSG00230027102
 protein coding gene Chr13:63179342-63181029 (-)
NOD/ShiLtJ ENSMUSG00190025559
 protein coding gene Chr13:52868832-52870517 (-)
NZO/HlLtJ ENSMUSG00225033241
 protein coding gene Chr13:56897701-56899385 (-)
PWK/PhJ ENSLUMG00010020312
 protein coding gene Chr13:52079606-52081292 (-)
SPRET/EiJ ENSMSPG00010031302
 protein coding gene Chr13:52515394-52516483 (-)
WSB/EiJ ENSIUOG00005022630
 protein coding gene Chr13:52293502-52295186 (-)



Homology
more
  • Human Ortholog
    NEUROG1, neurogenin 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NEUROG1, neurogenin 1
  • Synonyms
    AKA, bHLHa6, CCDDRD, Math4C, NEUROD3, ngn1
  • Links
    NCBI Gene ID: 4762
    UniProt: Q92886

  • Chr Location
    5q31.1; chr5:135534282-135535964 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    56 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit defects in midbrain, dorsal root sensory ganglia and a subset of cranial ganglia. Mutants are born alive, but fail to nurse, and die within 12 hours.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    72
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1247
  • Tissues
    302
  • cDNA Data
    17
  • Literature Summary
    232
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000048904 Ensembl Gene Model | MGI Sequence Detail 1686 C57BL/6J ±  kb
    transcript ENSMUST00000058475 Ensembl | MGI Sequence Detail 1686 Not Applicable  
    polypeptide ENSMUSP00000050484 Ensembl | MGI Sequence Detail 244 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 7
      cDNA 20
      Primer pair 13
      Other 16
      Antibodies 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36330
    References
    more
    • Summaries
      All 331
      Developmental Gene Expression 232
      Gene Ontology 16
      Phenotypes 56
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:379202 Desiderio S, et al., Expression dynamics of functionally equivalent Neurog1/2 genes enable protracted neurogenesis and temporal emergence of somatosensory neuron lineages. Cell Rep. 2026 Jan 27;45(1):116798
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory