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Dync1i2 Gene Detail
Summary
  • Symbol
    Dync1i2
  • Name
    dynein cytoplasmic 1 intermediate chain 2
  • Synonyms
    3110079H08Rik, Dncic2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107750
    NCBI Gene: 13427
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:71042050-71093647 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1166 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107750
 protein coding gene Chr2:71041999-71093647 (+)
129S1/SvImJ ENSMUSG00200035809
 protein coding gene Chr2:68100536-68152350 (+)
A/J ENSMUSG00195021736
 protein coding gene Chr2:68245636-68296900 (+)
AKR/J ENSMUSG00220037741
 protein coding gene Chr2:68210372-68261638 (+)
BALB/cJ ENSMUSG00180038972
 protein coding gene Chr2:68200706-68252303 (+)
C3H/HeJ ENSMUSG00175036547
 protein coding gene Chr2:68313040-68364290 (+)
C57BL/6NJ ENSMUSG00215021915
 protein coding gene Chr2:68138978-68190574 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023642
 protein coding gene Chr2:65748878-65799898 (+)
CAST/EiJ ENSTCUG00005009041
 protein coding gene Chr2:67617664-67669104 (+)
CBA/J ENSMUSG00210035274
 protein coding gene Chr2:68359966-68411567 (+)
DBA/2J ENSMUSG00185040283
 protein coding gene Chr2:68195605-68247210 (+)
FVB/NJ ENSMUSG00205028949
 protein coding gene Chr2:67656048-67707308 (+)
JF1/MsJ ENSUMUG00000004350
 protein coding gene Chr2:67855016-67906294 (+)
LP/J ENSMUSG00230019952
 protein coding gene Chr2:70000927-70052526 (+)
NOD/ShiLtJ ENSMUSG00190032587
 protein coding gene Chr2:68278732-68329996 (+)
NZO/HlLtJ ENSMUSG00225014913
 protein coding gene Chr2:77743230-77794827 (+)
PWK/PhJ ENSLUMG00010032997
 protein coding gene Chr2:68082367-68134079 (+)
SPRET/EiJ ENSMSPG00010034973
 protein coding gene Chr2:69480191-69531841 (+)
WSB/EiJ ENSIUOG00005018574
 protein coding gene Chr2:68324687-68376273 (+)



Homology
more
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
  • Synonyms
    DIC74, DNCI2, IC2, NEDMIBA
  • Links
    NCBI Gene ID: 1781
    UniProt: Q13409

  • Chr Location
    2q31.1; chr2:171687409-171750158 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    954
  • Tissues
    77
  • cDNA Data
    206
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000027012 Ensembl Gene Model | MGI Sequence Detail 51598 C57BL/6J ±  kb
    transcript ENSMUST00000112140 Ensembl | MGI Sequence Detail 2573 Not Applicable  
    polypeptide ENSMUSP00000107768 Ensembl | MGI Sequence Detail 638 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      12 Sequences
    • Protein Ontology
      PR:000006772 cytoplasmic dynein 1 intermediate chain 2
      (term hierarchy)
    • InterPro Domains
      IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2
      IPR050687 Dynein axonemal intermediate chain 1/2/3/4
      IPR001680 WD40 repeat
      IPR036322 WD40-repeat-containing domain superfamily
      IPR015943 WD40/YVTN repeat-like-containing domain superfamily
    • GlyGen
      O88487 1 site, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 221
      cDNA 207
      Primer pair 13
      Other 1
      Antibodies 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36326, MGI:1925763, MGI:2139394
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 15
      Gene Ontology 11
      Phenotypes 16
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory