Dync1i2
Gene Detail

Symbol Name ID

Dync1i2 dynein cytoplasmic 1 intermediate chain 2 MGI:107750

Synonyms

3110079H08Rik, Dncic2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

42.38 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr2:71211706-71263303 bp, + strand From VEGA annotation of GRCm38   51598 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37921  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Dync1i2

Human homologs

Human Homolog		DYNC1I2, dynein, cytoplasmic 1, intermediate chain 2
NCBI Gene ID		1781
neXtProt AC		NX_Q13409
Human Synonyms		DNCI2, IC2
Human Chr (Location)		2q31.1; chr2:172543982-172604919 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(65) : Targeted(2) Gene trapped(62) Chemically induced(1)
 

Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	microtubule-based movement, transport
Component	centrosome, cytoplasm, ...
Function	motor activity, protein complex binding

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (88)    Tissues (57)    Images (17)
Theiler Stages: 17, 19, 20, 21, 23, 28

Assay Type	Results
RNA in situ	79
Northern blot	9

cDNA source data(205)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(207) cDNA(206) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000013157 (Evidence)
Ensembl Gene Model	ENSMUSG00000027012 (Evidence)
Entrez Gene	13427 (Evidence)
UniGene	249479
DFCI	TC1571858, TC1735516
DoTS	DT.101158315, DT.101158368, DT.101234191, DT.494644, DT.55214219, DT.91333448, DT.91398894, DT.99871342, DT.99871344
NIA Mouse Gene Index	U001891
Consensus CDS Project	CCDS16112.1, CCDS57175.1
International Mouse Knockout Project Status	Dync1i2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013157	VEGA Gene Model | MGI Sequence Detail	51598	C57BL/6J
transcript	OTTMUST00000042241	VEGA | MGI Sequence Detail	2573	Not Applicable
polypeptide	OTTMUSP00000018982	VEGA | MGI Sequence Detail	638	Not Applicable

All sequences(107) RefSeq(16) UniProt(11)

Polymorphisms

RFLP(1) : SNPs(278 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR025956	Cytoplasmic dynein 1 intermediate chain 1/2
InterPro	IPR001680	WD40 repeat
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000006772	cytoplasmic dynein 1 intermediate chain 2

References

(Earliest) J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(49)

Other accession IDs

MGD-MRK-36326, MGI:1925763, MGI:2139394