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Dync1i2 Gene Detail
Summary
  • Symbol
    Dync1i2
  • Name
    dynein cytoplasmic 1 intermediate chain 2
  • Synonyms
    3110079H08Rik, Dncic2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107750
    NCBI Gene: 13427
  • Gene Overview
    MyGene.info: DYNC1I2
Location & Maps
more
  • Sequence Map
    Chr2:71211706-71263303 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51598 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 42.38 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    DYNC1I2, dynein cytoplasmic 1 intermediate chain 2
    Orthology source: HGNC
  • Synonyms
    DIC74, DNCI2, IC2
  • Links
    NCBI Gene ID: 1781
    neXtProt AC: NX_Q13409

  • Chr Location
    2q31.1; chr2:171687409-171750158 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    66
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    62
  • Targeted
    2
  • Genomic Mutations
    1 involving Dync1i2
  • Incidental Mutations
Mice homozygous for an ENU-induced allele exhibit a trend towards slight locomotor deficit.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013157 VEGA Gene Model | MGI Sequence Detail 51598 C57BL/6J ±  kb
transcript OTTMUST00000042241 VEGA | MGI Sequence Detail 2573 Not Applicable  
polypeptide OTTMUSP00000018982 VEGA | MGI Sequence Detail 638 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    389 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    11 Sequences
  • Protein Ontology
    PR:000006772 cytoplasmic dynein 1 intermediate chain 2
  • InterPro Domains
    IPR025956 Cytoplasmic dynein 1 intermediate chain 1/2
    IPR001680 WD40 repeat
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 208
    cDNA 206
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36326, MGI:1925763, MGI:2139394
References
more
  • Summaries
    All 44
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 12
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory