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Dnah6 Gene Detail
Summary
  • Symbol
    Dnah6
  • Name
    dynein, axonemal, heavy chain 6
  • Synonyms
    A730004I20Rik, Dnahc6
  • Feature Type
    protein coding gene
  • IDs
    MGI:107744
    NCBI Gene: 330355
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:73017606-73221651 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 32.37 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1289 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107744
protein coding gene Chr6:73017606-73222403 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030886
protein coding gene Chr6:73637647-73836246 (-)
A/J MGP_AJ_G0030856
protein coding gene Chr6:70721069-70915322 (-)
AKR/J MGP_AKRJ_G0030785
protein coding gene Chr6:72850598-73044344 (-)
BALB/cJ MGP_BALBcJ_G0030867
protein coding gene Chr6:70778237-70980255 (-)
C3H/HeJ MGP_C3HHeJ_G0030845
protein coding gene Chr6:111204300-111402114 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031325
protein coding gene Chr6:75540622-75733843 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028514
protein coding gene Chr6:69901551-70096909 (-)
CAST/EiJ MGP_CASTEiJ_G0029975
protein coding gene Chr6:72726765-72939962 (-)
CBA/J MGP_CBAJ_G0030554
protein coding gene Chr6:78657789-78862299 (-)
DBA/2J MGP_DBA2J_G0030706
protein coding gene Chr6:70136374-70328209 (-)
FVB/NJ MGP_FVBNJ_G0030659
protein coding gene Chr6:69537085-69730066 (-)
LP/J MGP_LPJ_G0030785
protein coding gene Chr6:73532835-73739288 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030694
protein coding gene Chr6:81995564-82197504 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031351
protein coding gene Chr6:72675770-72881095 (-)
PWK/PhJ MGP_PWKPhJ_G0029691
protein coding gene Chr6:69073309-69274880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029519
protein coding gene Chr6:71431083-71646683 (-)
WSB/EiJ MGP_WSBEiJ_G0030057
protein coding gene Chr6:73051486-73263682 (-)



Homology
more
  • Human Ortholog
    DNAH6, dynein axonemal heavy chain 6
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DNAH6, dynein axonemal heavy chain 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Dnahc6, DNHL1, HL2, HL-2
  • Links
    NCBI Gene ID: 1768
    neXtProt AC: NX_Q9C0G6
    UniProt: Q9C0G6

  • Chr Location
    2p11.2; chr2:84459588-84819589 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052861 Ensembl Gene Model | MGI Sequence Detail 204046 C57BL/6J ±  kb
transcript ENSMUST00000064948 Ensembl | MGI Sequence Detail 12652 Not Applicable  
polypeptide ENSMUSP00000068758 Ensembl | MGI Sequence Detail 4144 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    5 Sequences
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR026983 Dynein heavy chain
    IPR026980 Dynein heavy chain 6, axonemal
    IPR024317 Dynein heavy chain, AAA module D4
    IPR035706 Dynein heavy chain, ATP-binding dynein motor region
    IPR024743 Dynein heavy chain, coiled coil stalk
    IPR013602 Dynein heavy chain, domain-2
    IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
    IPR004273 Dynein heavy chain region D6 P-loop domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
less
  • All nucleic 10
    cDNA 10

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36320, MGI:3036252
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 5
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:262471 Li Y, et al., DNAH6 and Its Interactions with PCD Genes in Heterotaxy and Primary Ciliary Dyskinesia. PLoS Genet. 2016 Feb;12(2):e1005821

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
03/19/2019
MGI 6.13
The Jackson Laboratory