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Stra6 Gene Detail
Summary
  • Symbol
    Stra6
  • Name
    stimulated by retinoic acid gene 6
  • Feature Type
    protein coding gene
  • IDs
    MGI:107742
    NCBI Gene: 20897
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:58063788-58153996 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.63 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    474 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107742
protein coding gene Chr9:58063788-58154004 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034884
protein coding gene Chr9:57329124-57423719 (+)
A/J MGP_AJ_G0034865
protein coding gene Chr9:55469398-55560774 (+)
AKR/J MGP_AKRJ_G0034794
protein coding gene Chr9:56762884-56854850 (+)
BALB/cJ MGP_BALBcJ_G0034857
protein coding gene Chr9:55243691-55334816 (+)
C3H/HeJ MGP_C3HHeJ_G0034567
protein coding gene Chr9:57234089-57326059 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035376
protein coding gene Chr9:58909684-59013010 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032287
protein coding gene Chr9:54755467-54846808 (+)
CAST/EiJ MGP_CASTEiJ_G0033888
protein coding gene Chr9:57326832-57421508 (+)
CBA/J MGP_CBAJ_G0034538
protein coding gene Chr9:60986814-61087741 (+)
DBA/2J MGP_DBA2J_G0034697
protein coding gene Chr9:55327048-55418570 (+)
FVB/NJ MGP_FVBNJ_G0034639
protein coding gene Chr9:54562386-54652349 (+)
LP/J MGP_LPJ_G0034780
protein coding gene Chr9:57615501-57707888 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034682
protein coding gene Chr9:62459368-62549992 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035398
protein coding gene Chr9:56774647-56866590 (+)
PWK/PhJ MGP_PWKPhJ_G0033593
protein coding gene Chr9:55368224-55461595 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033427
protein coding gene Chr9:57040507-57136351 (+)
WSB/EiJ MGP_WSBEiJ_G0034001
protein coding gene Chr9:56709270-56803478 (+)



Homology
more
  • Human Ortholog
    STRA6, stimulated by retinoic acid 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STRA6, stimulated by retinoic acid 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCOPCB8, MCOPS9, PP14296
  • Links
    NCBI Gene ID: 64220
    neXtProt AC: NX_Q9BX79
    UniProt: Q9BX79

  • Chr Location
    15q24.1; chr15:74179466-74212267 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7554
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: STRA6
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human STRA6 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Male mice homozygous for a gene trap allele exhibit growth retardation. Mice homozygous for a knock-out allele exhibit persistent hyperplastic primary vitreous, shorter inner and outer segment and reduced rod and cone function.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032327 Ensembl Gene Model | MGI Sequence Detail 90209 C57BL/6J ±  kb
    transcript ENSMUST00000034880 Ensembl | MGI Sequence Detail 2993 Not Applicable  
    polypeptide ENSMUSP00000034880 Ensembl | MGI Sequence Detail 670 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 1
      cDNA 47
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36318, MGI:2143166
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 12
      Gene Ontology 6
      Phenotypes 14
    • Earliest
      J:28316 Bouillet P, et al., Efficient cloning of cDNAs of retinoic acid-responsive genes in P19 embryonal carcinoma cells and characterization of a novel mouse gene, Stra1 (mouse LERK-2/Eplg2). Dev Biol. 1995 Aug;170(2):420-33
    • Latest
      J:245614 Gliniak CM, et al., The retinol-binding protein receptor STRA6 regulates diurnal insulin responses. J Biol Chem. 2017 Sep 08;292(36):15080-15093

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory