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Pvr Gene Detail
Summary
  • Symbol
    Pvr
  • Name
    poliovirus receptor
  • Synonyms
    3830421F03Rik, CD155, D7Ertd458e, mE4, necl-5, Taa1, Tage4
  • Feature Type
    protein coding gene
  • IDs
    MGI:107741
    NCBI Gene: 52118
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:19903578-19921143 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 9.95 cM, cytoband A2-B1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    122 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107741
protein coding gene Chr7:19903578-19921160 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031801
protein coding gene Chr7:17959857-17976348 (-)
A/J MGP_AJ_G0031777
protein coding gene Chr7:17558524-17580877 (-)
AKR/J MGP_AKRJ_G0031703
protein coding gene Chr7:18051099-18068509 (-)
BALB/cJ MGP_BALBcJ_G0031782
protein coding gene Chr7:17768040-17782669 (-)
C3H/HeJ MGP_C3HHeJ_G0031504
protein coding gene Chr7:18315831-18332097 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032248
protein coding gene Chr7:18850467-18871919 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029314
protein coding gene Chr7:19196512-19214024 (-)
CAST/EiJ MGP_CASTEiJ_G0030847
protein coding gene Chr7:14775461-14793231 (-)
CBA/J MGP_CBAJ_G0031466
protein coding gene Chr7:19546851-19565634 (-)
DBA/2J MGP_DBA2J_G0031621
protein coding gene Chr7:17507379-17524985 (-)
FVB/NJ MGP_FVBNJ_G0031573
protein coding gene Chr7:17391125-17409721 (-)
LP/J MGP_LPJ_G0031704
protein coding gene Chr7:18263278-18294878 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031609
protein coding gene Chr7:19356395-19373961 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032276
protein coding gene Chr7:17667451-17689198 (-)
PWK/PhJ MGP_PWKPhJ_G0030571
protein coding gene Chr7:14616211-14634303 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030398
protein coding gene Chr7:12386096-12404181 (-)
WSB/EiJ MGP_WSBEiJ_G0030947
protein coding gene Chr7:17890503-17910336 (-)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null allele have a reduced antibody response to oral immunization. Mice homozygous for a different null allele exhibit reduced susceptibility to chemically induced colon cancer.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 52118 NCBI Gene Model | MGI Sequence Detail 17566 C57BL/6J ±  kb
transcript NM_027514 RefSeq | MGI Sequence Detail 2902 C57BL/6  
polypeptide NP_081790 RefSeq | MGI Sequence Detail 408 C57BL/6  
For the selected sequence
Protein
Information
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Molecular
Reagents
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  • All nucleic 70
    cDNA 69
    Primer pair 1

    Microarray probesets 8
Other
Accession IDs
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MGD-MRK-36317, MGI:1196266, MGI:1917954
References
more
  • Summaries
    All 65
    Developmental Gene Expression 1
    Gene Ontology 10
    Phenotypes 23
  • Earliest
    J:153943 Koike S, et al., Transgenic mice susceptible to poliovirus. Proc Natl Acad Sci U S A. 1991 Feb 1;88(3):951-5
  • Latest
    J:268098 Takenaka E, et al., Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4(+) T cell costimulation. Sci Rep. 2018 Oct 12;8(1):15180

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/04/2019
MGI 6.14
The Jackson Laboratory