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Myo9a Gene Detail
Summary
  • Symbol
    Myo9a
  • Name
    myosin IXa
  • Synonyms
    4732465J09Rik, C130068I12Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107735
    NCBI Gene: 270163
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:59750896-59928866 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 32.13 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    301 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107735
protein coding gene Chr9:59750843-59928866 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034907
protein coding gene Chr9:59123574-59316608 (+)
A/J MGP_AJ_G0034887
protein coding gene Chr9:57222864-57413387 (+)
AKR/J MGP_AKRJ_G0034817
protein coding gene Chr9:58550949-58744605 (+)
BALB/cJ MGP_BALBcJ_G0034880
protein coding gene Chr9:56952805-57132446 (+)
C3H/HeJ MGP_C3HHeJ_G0034590
protein coding gene Chr9:59032727-59221855 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035399
protein coding gene Chr9:60754110-60942855 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032310
protein coding gene Chr9:56958836-57132015 (+)
CAST/EiJ MGP_CASTEiJ_G0033911
protein coding gene Chr9:59130666-59319887 (+)
CBA/J MGP_CBAJ_G0034561
protein coding gene Chr9:62893465-63097961 (+)
DBA/2J MGP_DBA2J_G0034720
protein coding gene Chr9:57035686-57219508 (+)
FVB/NJ MGP_FVBNJ_G0034662
protein coding gene Chr9:56295909-56487770 (+)
LP/J MGP_LPJ_G0034803
protein coding gene Chr9:59417289-59611911 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034705
protein coding gene Chr9:64327057-64559351 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035421
protein coding gene Chr9:58557744-58758395 (+)
PWK/PhJ MGP_PWKPhJ_G0033615
protein coding gene Chr9:57100823-57288006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033448
protein coding gene Chr9:58825638-59020105 (+)
WSB/EiJ MGP_WSBEiJ_G0034024
protein coding gene Chr9:58503477-58693936 (+)



Homology
more
  • Human Ortholog
    MYO9A, myosin IXA
  • Vertebrate Orthologs
    10
  • Human Ortholog
    MYO9A, myosin IXA
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CMS24
  • Links
    NCBI Gene ID: 4649
    neXtProt AC: NX_B2RTY4
    UniProt: B2RTY4

  • Chr Location
    15q23; chr15:71822290-72118577 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21371
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MYO9A
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Myo9a mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous KO leads to obstructive hydrocephaly caused by blockage of the third ventricle and the rostral aqueduct caused by developmental failures of their ependymal cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039585 Ensembl Gene Model | MGI Sequence Detail 177971 C57BL/6J ±  kb
    transcript ENSMUST00000136740 Ensembl | MGI Sequence Detail 12252 Not Applicable  
    polypeptide ENSMUSP00000122852 Ensembl | MGI Sequence Detail 2631 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • InterPro Domains
      IPR036023 Class IX myosin, motor domain
      IPR000048 IQ motif, EF-hand binding site
      IPR036961 Kinesin motor domain superfamily
      IPR001609 Myosin head, motor domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
      IPR002219 Protein kinase C-like, phorbol ester/diacylglycerol-binding domain
      IPR000159 Ras-associating (RA) domain
      IPR000198 Rho GTPase-activating protein domain
      IPR008936 Rho GTPase activation protein
      IPR029071 Ubiquitin-like domain superfamily
      IPR028558 Unconventional myosin-IXa
    Molecular
    Reagents
    less
    • All nucleic 83
      cDNA 83

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36311, MGI:2442529, MGI:2445013
    References
    more
    • Summaries
      All 38
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 14
    • Earliest
      J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
    • Latest
      J:260494 O'Connor E, et al., MYO9A deficiency in motor neurons is associated with reduced neuromuscular agrin secretion. Hum Mol Genet. 2018 Apr 15;27(8):1434-1446

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    03/13/2019
    MGI 6.13
    The Jackson Laboratory