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Myo1a Gene Detail
Summary
  • Symbol
    Myo1a
  • Name
    myosin IA
  • Synonyms
    BBM-I, brush border myosin 1, Myhl
  • Feature Type
    protein coding gene
  • IDs
    MGI:107732
    NCBI Gene: 432516
  • Gene Overview
    MyGene.info: MYO1A
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:127705170-127720940 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 74.62 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107732
protein coding gene Chr10:127703437-127720940 (.)
129S1/SvImJ MGP_129S1SvImJ_G0017831
protein coding gene Chr10:131331012-131360258 (+)
A/J MGP_AJ_G0017806
protein coding gene Chr10:126077850-126104926 (+)
AKR/J MGP_AKRJ_G0017769
protein coding gene Chr10:129797437-129823700 (+)
BALB/cJ MGP_BALBcJ_G0017770
protein coding gene Chr10:126478569-126505070 (+)
C3H/HeJ MGP_C3HHeJ_G0017594
protein coding gene Chr10:129952624-129981218 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018225
protein coding gene Chr10:135780293-135808675 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015905
protein coding gene Chr10:120060224-120085998 (+)
CAST/EiJ MGP_CASTEiJ_G0017154
protein coding gene Chr10:130618868-130648564 (+)
CBA/J MGP_CBAJ_G0017563
protein coding gene Chr10:141262809-141292599 (+)
DBA/2J MGP_DBA2J_G0017669
protein coding gene Chr10:125150822-125178111 (+)
FVB/NJ MGP_FVBNJ_G0017664
protein coding gene Chr10:124094327-124110337 (+)
LP/J MGP_LPJ_G0017743
protein coding gene Chr10:131907301-131935092 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017692
protein coding gene Chr10:143938633-143968260 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018265
protein coding gene Chr10:129874800-129903515 (+)
PWK/PhJ MGP_PWKPhJ_G0016939
protein coding gene Chr10:125359356-125386435 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016731
protein coding gene Chr10:128903160-128929163 (+)
WSB/EiJ MGP_WSBEiJ_G0017215
protein coding gene Chr10:130093236-130122591 (+)



Homology
more
  • Human Ortholog
    MYO1A, myosin IA
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYO1A, myosin IA
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BBMI, DFNA48, MIHC, MYHL
  • Links
    NCBI Gene ID: 4640
    neXtProt AC: NX_Q9UBC5
    UniProt: Q9UBC5

  • Chr Location
    12q13.3; chr12:57028517-57050765 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025401 Ensembl Gene Model | MGI Sequence Detail 15771 C57BL/6J ±  kb
    transcript ENSMUST00000079590 Ensembl | MGI Sequence Detail 3439 Not Applicable  
    polypeptide ENSMUSP00000078540 Ensembl | MGI Sequence Detail 1043 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      Genomic 2
      cDNA 17
      Primer pair 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36308, MGI:1338019
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 4
      Gene Ontology 8
      Phenotypes 9
    • Earliest
      J:4139 Sherr EH, et al., Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol. 1993 Mar;120(6):1405-16
    • Latest
      J:219622 Revenu C, et al., A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell. 2012 Jan;23(2):324-36

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory