About   Help   FAQ
Myo1a
Gene Detail
 Symbol
Name
ID
Myo1a
myosin IA
MGI:107732
Synonyms BBM-I, brush border myosin 1, Myhl
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:127705256-127720940 bp, + strand
From NCBI annotation of GRCm38

  15685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: myosin I
Gene Tree: Myo1a

Human
homologs
Human Homolog MYO1A, myosin IA
NCBI Gene ID 4640
neXtProt AC  NX_Q9UBC5
Human Synonyms  BBMI, DFNA48, MIHC, MYHL
Human Chr (Location)  12q13-q14; chr12:57028517-57050765 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human MYO1A
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.
 
Interactions
Myo1a interacts with 52 markers (Mir20a, Mir22, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cell projection organization, microvillus assembly, ...
Component actin cytoskeleton, apical plasma membrane, ...
Function actin binding, ATP binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (5)   
Theiler Stages: 22, 24, 26, 28
Assay TypeResults
RT-PCR 5
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(16) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000025401 (Evidence)
Entrez Gene432516 (Evidence)
UniGene90450
DFCITC1606232, TC1608124
DoTSDT.55205307, DT.91576577
NIA Mouse Gene IndexU012157
Consensus CDS ProjectCCDS36083.1
International Mouse Knockout Project StatusMyo1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 432516 NCBI Gene Model | MGI Sequence Detail 15685 C57BL/6J ±  kb
transcript NM_001081219 RefSeq | MGI Sequence Detail 3353 C57BL/6 
polypeptide O88329 UniProt | EBI | MGI Sequence Detail 1043 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR010926 Myosin tail 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010855 myosin-Ia
Graphical View of Protein Domain Structure
References (Earliest) J:4139 Sherr EH, et al., Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol. 1993 Mar;120(6):1405-16
(Latest) J:181908 Mazzolini R, et al., Brush border myosin Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1530-5
All references(40)
Other
accession IDs
MGD-MRK-36308, MGI:1338019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory