Myo1a
Gene Detail

Symbol Name ID

Myo1a myosin IA MGI:107732

Synonyms

BBM-I, brush border myosin 1, Myhl

Feature Type

protein coding gene

Genetic Map

Chromosome 10

74.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr10:127705256-127720940 bp, + strand From NCBI annotation of GRCm38   15685 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: myosin I
Gene Tree: Myo1a

Human homologs

Human Homolog		MYO1A, myosin IA
NCBI Gene ID		4640
neXtProt AC		NX_Q9UBC5
Human Synonyms		BBMI, DFNA48, MIHC, MYHL
Human Chr (Location)		12q13-q14; chr12:57422301-57444549 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human MYO1A

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	cell projection organization, microvillus assembly, ...
Component	actin cytoskeleton, apical plasma membrane, ...
Function	actin binding, ATP binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (5)   
Theiler Stages: 22, 24, 26, 28

Assay Type	Results
RT-PCR	5

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(2) cDNA(16) Primer pair(1)
Microarray probesets(2)

Other database links

Ensembl Gene Model	ENSMUSG00000025401 (Evidence)
Entrez Gene	432516 (Evidence)
UniGene	90450
DFCI	TC1606232, TC1608124
DoTS	DT.55205307, DT.91576577
NIA Mouse Gene Index	U012157
Consensus CDS Project	CCDS36083.1
International Mouse Knockout Project Status	Myo1a

Sequences

Length	Strain/Species
genomic	432516	NCBI Gene Model | MGI Sequence Detail	15685	C57BL/6J
transcript	NM_001081219	RefSeq | MGI Sequence Detail	3353	C57BL/6
polypeptide	O88329	UniProt | EBI | MGI Sequence Detail	1043	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(95 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR001609	Myosin head, motor domain
InterPro	IPR010926	Myosin tail 2
Protein Ontology	PR:000010855	myosin-Ia

Graphical View of Protein Domain Structure

References

(Earliest) J:4139 Sherr EH, et al., Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol. 1993 Mar;120(6):1405-16
(Latest) J:181908 Mazzolini R, et al., Brush border myosin Ia has tumor suppressor activity in the intestine. Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1530-5
All references(39)

Other accession IDs

MGD-MRK-36308, MGI:1338019