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Myo1a
Gene Detail
Symbol

Name
ID
Myo1a
myosin IA
MGI:107732
Synonyms
BBM-I, brush border myosin 1, Myhl
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.62 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr10:127705170-127720887 bp, + strand
From Ensembl annotation of GRCm38

  15718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21113  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: MYO1A
Protein SuperFamily: myosin I
Gene Tree: Myo1a

Human
homologs
MYO1A, myosin IA
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4640
neXtProt AC: NX_Q9UBC5

Human Synonyms: BBMI, DFNA48, MIHC, MYHL

Human Chr (Location): 12q13-q14; chr12:57028517-57050765 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human MYO1A

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice display abnormal small intestine brush border morphology, but have normal hearing.
 
Interactions
Myo1a interacts with 52 markers (Mir20a, Mir22, Mir26a-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process cell projection organization, microvillus assembly, ...
Component actin cytoskeleton, apical plasma membrane, ...
Function actin binding, actin filament binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (5)    Tissues (5)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 5
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase myo1a    NEW 
Molecular
reagents
All nucleic(19) Genomic(2) cDNA(16) Primer pair(1)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000025401 (Evidence)
Entrez Gene 432516 (Evidence)
UniGene 90450
DFCI TC1606232, TC1608124
DoTS DT.55205307, DT.91576577
NIA Mouse Gene Index U012157
Consensus CDS Project CCDS36083.1
International Mouse Phenotyping Consortium Status Myo1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025401 Ensembl Gene Model | MGI Sequence Detail 15718 C57BL/6J ±  kb
transcript ENSMUST00000079590 Ensembl | MGI Sequence Detail 3386 Not Applicable 
polypeptide ENSMUSP00000078540 Ensembl | MGI Sequence Detail 1043 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(119 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000048 IQ motif, EF-hand binding site
InterPro IPR001609 Myosin head, motor domain
InterPro IPR010926 Myosin tail 2
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010855 myosin-Ia
References
(Earliest) J:4139 Sherr EH, et al., Mammalian myosin I alpha, I beta, and I gamma: new widely expressed genes of the myosin I family. J Cell Biol. 1993 Mar;120(6):1405-16
(Latest) J:219622 Revenu C, et al., A new role for the architecture of microvillar actin bundles in apical retention of membrane proteins. Mol Biol Cell. 2012 Jan;23(2):324-36
All references(41)
Other
accession IDs
MGD-MRK-36308, MGI:1338019

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory