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Dnah2 Gene Detail
Summary
  • Symbol
    Dnah2
  • Name
    dynein, axonemal, heavy chain 2
  • Synonyms
    2900022L05Rik, D330014H01Rik, Dnahc2, Dnhd3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107731
    NCBI Gene: 327954
Location & Maps
more
  • Sequence Map
    Chr11:69420809-69549110 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      128302 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.63 cM, cytoband B4
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DNAH2, dynein axonemal heavy chain 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DNAH2, dynein axonemal heavy chain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAHC2, DNHD3
  • Links
    NCBI Gene ID: 146754
    neXtProt AC: NX_Q9P225

  • Chr Location
    17p13.1; chr17:7717354-7833744 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    23
  • Chemically induced (other)
    1
  • Gene trapped
    20
  • Targeted
    2
  • Genomic Mutations
    1 involving Dnah2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005984 VEGA Gene Model | MGI Sequence Detail 128302 C57BL/6J ±  kb
transcript OTTMUST00000013386 VEGA | MGI Sequence Detail 13569 Not Applicable  
polypeptide OTTMUSP00000006198 VEGA | MGI Sequence Detail 4456 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1124 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006562 dynein heavy chain 2, axonemal
  • InterPro Domains
    IPR003593 AAA+ ATPase domain
    IPR011704 ATPase, dynein-related, AAA domain
    IPR026983 Dynein heavy chain
    IPR024743 Dynein heavy chain, coiled coil stalk
    IPR004273 Dynein heavy chain domain
    IPR013594 Dynein heavy chain, domain-1
    IPR013602 Dynein heavy chain, domain-2
    IPR024317 Dynein heavy chain, P-loop containing D4 domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 13
    cDNA 13

    Microarray probesets 2
Other
Accession IDs
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MGD-MRK-36307, MGI:1920132, MGI:2441970
References
more
  • Summaries
    All 28
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 8
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory