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Igtp Gene Detail
Summary
  • Symbol
    Igtp
  • Name
    interferon gamma induced GTPase
  • Synonyms
    Irgm3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107729
    NCBI Gene: 16145
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:58199556-58207591 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 36.01 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    88 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107729
protein coding gene Chr11:58199556-58207592 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018345
protein coding gene Chr11:57879025-57889282 (+)
A/J MGP_AJ_G0018315
protein coding gene Chr11:55668831-55694896 (+)
AKR/J MGP_AKRJ_G0018284
protein coding gene Chr11:57513894-57522505 (+)
BALB/cJ MGP_BALBcJ_G0018286
protein coding gene Chr11:56026686-56034770 (+)
C3H/HeJ MGP_C3HHeJ_G0018097
protein coding gene Chr11:57451646-57459878 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018737
protein coding gene Chr11:59659628-59674125 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016387
protein coding gene Chr11:53038990-53044751 (+)
CAST/EiJ MGP_CASTEiJ_G0017662
protein coding gene Chr11:57544739-57554316 (+)
CBA/J MGP_CBAJ_G0018072
protein coding gene Chr11:62410240-62420090 (+)
DBA/2J MGP_DBA2J_G0018181
protein coding gene Chr11:55334331-55342303 (+)
FVB/NJ MGP_FVBNJ_G0018172
protein coding gene Chr11:55028157-55035916 (+)
LP/J MGP_LPJ_G0018256
protein coding gene Chr11:58412365-58420323 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018198
protein coding gene Chr11:63523880-63532664 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018780
protein coding gene Chr11:57557790-57567224 (+)
PWK/PhJ MGP_PWKPhJ_G0017434
protein coding gene Chr11:55940152-55946299 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017229
protein coding gene Chr11:57438778-57446870 (+)
WSB/EiJ MGP_WSBEiJ_G0017709
protein coding gene Chr11:57187697-57198837 (+)



Homology
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display an essentially normal phenotype. They do have a severely compromised response to Toxoplasma gondii infections however
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000078853 Ensembl Gene Model | MGI Sequence Detail 8036 C57BL/6J ±  kb
    transcript ENSMUST00000035266 Ensembl | MGI Sequence Detail 2022 Not Applicable  
    polypeptide ENSMUSP00000047356 Ensembl | MGI Sequence Detail 423 Not Applicable  
    For the selected sequence
    Protein
    Information
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    • UniProt
      6 Sequences
    • InterPro Domains
      IPR007743 Immunity-related GTPases-like
      IPR030385 IRG-type guanine nucleotide-binding (G) domain
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
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    • All nucleic 134
      cDNA 133
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36305, MGI:2144580
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 1
      Gene Ontology 3
      Phenotypes 24
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:241213 Feeley EM, et al., Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. Proc Natl Acad Sci U S A. 2017 Feb 28;114(9):E1698-E1706

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/08/2019
    MGI 6.14
    The Jackson Laboratory