About   Help   FAQ
Igtp
Gene Detail
 Symbol
Name
ID
Igtp
interferon gamma induced GTPase
MGI:107729
Synonyms Irgm3
Feature Type protein coding gene
Genetic Map
Chromosome 11
36.01 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr11:58199556-58207591 bp, + strand
From VEGA annotation of GRCm38

  8036 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:23118  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Igtp

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an essentially normal phenotype. They do have a severely compromised response to Toxoplasma gondii infections however
 
Interactions
Igtp interacts with 128 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (4 annotations)
Process cellular response to interferon-beta, GTP catabolic process
Component cytosol
Function GTPase activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (94)    Tissues (94)    Images (2)
Theiler Stages: 22
Assay TypeResults
RNA in situ 94
cDNA source data(132)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) cDNA(132) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005727 (Evidence)
Ensembl Gene ModelENSMUSG00000078853 (Evidence)
Entrez Gene16145 (Evidence)
UniGene33902
DFCITC1577058
DoTSDT.101390198, DT.491879
Consensus CDS ProjectCCDS24725.1
International Mouse Knockout Project StatusIgtp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005727 VEGA Gene Model | MGI Sequence Detail 8036 C57BL/6J ±  kb
transcript OTTMUST00000012730 VEGA | MGI Sequence Detail 2022 Not Applicable 
polypeptide OTTMUSP00000005900 VEGA | MGI Sequence Detail 423 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(6)
Polymorphisms RFLP(1) : SNPs within 2kb(93 from dbSNP Build 137)    SNPs within 2kb including multiple locations(101)
Protein-related
information
ResourceIDDescription
InterPro IPR007743 Interferon-inducible GTPase
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
References (Earliest) J:34886 Taylor GA, et al., Identification of a novel GTPase, the inducibly expressed GTPase, that accumulates in response to interferon gamma. J Biol Chem. 1996 Aug 23;271(34):20399-405
(Latest) J:208845 Pilla DM, et al., Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. Proc Natl Acad Sci U S A. 2014 Apr 22;111(16):6046-51
All references(48)
Other
accession IDs
MGD-MRK-36305, MGI:2144580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/26/2014
MGI 5.19
The Jackson Laboratory