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Dnah1
Gene Detail
Symbol

Name
ID
Dnah1
dynein, axonemal, heavy chain 1
MGI:107721
Synonyms
B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7
Feature Type
protein coding gene
Genetic Map
Chromosome 14
19.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:31260375-31323896 bp, - strand
From Ensembl annotation of GRCm38

  63522 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:67131  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: dynein heavy chain, ciliary
Gene Tree: Dnah1

Human
homologs
Human Homolog DNAH1, dynein, axonemal, heavy chain 1
NCBI Gene ID 25981
neXtProt AC  NX_Q9P2D7
Human Synonyms  DNAHC1, HDHC7, HL11, HL-11, HSRF-1, XLHSRF-1
Human Chr (Location)  3p21.1; chr3:52302896-52400497 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia.
 
Interactions
Dnah1 interacts with 107 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process microtubule-based movement
Component axonemal dynein complex
Function microtubule motor activity
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (45)    Tissues (3)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 45
cDNA source data(14)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(15)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000019027 (Evidence)
Entrez Gene110084 (Evidence)
UniGene101811
DFCITC1703668, TC1588321, TC1585116
DoTSDT.91363617, DT.101715581, DT.94174401, DT.94276194
NIA Mouse Gene IndexU035372
Consensus CDS ProjectCCDS49436.1
International Mouse Knockout Project StatusDnah1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019027 Ensembl Gene Model | MGI Sequence Detail 63522 C57BL/6J ±  kb
transcript ENSMUST00000048603 Ensembl | MGI Sequence Detail 12872 Not Applicable 
polypeptide ENSMUSP00000043281 Ensembl | MGI Sequence Detail 4250 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(8) UniProt(12)
Polymorphisms
RFLP(1) : SNPs within 2kb(442 from dbSNP Build 137)    SNPs within 2kb including multiple locations(456)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR011704 ATPase, dynein-related, AAA domain
InterPro IPR026983 Dynein heavy chain
InterPro IPR026975 Dynein heavy chain 1, axonemal
InterPro IPR024743 Dynein heavy chain, coiled coil stalk
InterPro IPR004273 Dynein heavy chain domain
InterPro IPR013602 Dynein heavy chain, domain-2
InterPro IPR024317 Dynein heavy chain, P-loop containing D4 domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000006555 dynein heavy chain 1, axonemal
References
(Earliest) J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
(Latest) J:198514 Raaijmakers JA, et al., Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013 Apr 15;201(2):201-15
All references(30)
Other
accession IDs
MGD-MRK-36297, MGI:2442419, MGI:2444537

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory