About   Help   FAQ
Dnah1 Gene Detail
Summary
  • Symbol
    Dnah1
  • Name
    dynein, axonemal, heavy chain 1
  • Synonyms
    B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107721
    NCBI Gene: 110084
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:31260375-31323896 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.10 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    444 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107721
protein coding gene Chr14:31260375-31326068 (-)
129S1/SvImJ MGP_129S1SvImJ_G0021126
protein coding gene Chr14:24436424-24502349 (-)
A/J MGP_AJ_G0021074
protein coding gene Chr14:23513944-23577382 (-)
AKR/J MGP_AKRJ_G0021051
protein coding gene Chr14:24637901-24701537 (-)
BALB/cJ MGP_BALBcJ_G0021078
protein coding gene Chr14:23639030-23703233 (-)
C3H/HeJ MGP_C3HHeJ_G0020861
protein coding gene Chr14:24509198-24572478 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021510
protein coding gene Chr14:25404174-25467219 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019073
protein coding gene Chr14:23579335-23649569 (-)
CAST/EiJ MGP_CASTEiJ_G0020386
protein coding gene Chr14:24274268-24337098 (-)
CBA/J MGP_CBAJ_G0020828
protein coding gene Chr14:26376646-26439934 (-)
DBA/2J MGP_DBA2J_G0020950
protein coding gene Chr14:23544293-23607664 (-)
FVB/NJ MGP_FVBNJ_G0020934
protein coding gene Chr14:23506612-23570033 (-)
LP/J MGP_LPJ_G0021019
protein coding gene Chr14:24764592-24830326 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020960
protein coding gene Chr14:25641792-25705011 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021543
protein coding gene Chr14:24399054-24463052 (-)
PWK/PhJ MGP_PWKPhJ_G0020134
protein coding gene Chr14:23002810-23067688 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019958
protein coding gene Chr14:23997704-24066611 (-)
WSB/EiJ MGP_WSBEiJ_G0020441
protein coding gene Chr14:24461856-24526387 (-)



Homology
more
  • Human Ortholog
    DNAH1, dynein axonemal heavy chain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAH1, dynein axonemal heavy chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CILD37, DNAHC1, HDHC7, HL11, HL-11, HSRF-1, SPGF18, XLHSRF-1
  • Links
    NCBI Gene ID: 25981
    neXtProt AC: NX_Q9P2D7
    UniProt: Q9P2D7

  • Chr Location
    3p21.1; chr3:52313010-52400497 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DNAH1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000019027 Ensembl Gene Model | MGI Sequence Detail 63522 C57BL/6J ±  kb
    transcript ENSMUST00000048603 Ensembl | MGI Sequence Detail 12872 Not Applicable  
    polypeptide ENSMUSP00000043281 Ensembl | MGI Sequence Detail 4250 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000006555 dynein heavy chain 1, axonemal
    • InterPro Domains
      IPR011704 ATPase, dynein-related, AAA domain
      IPR026983 Dynein heavy chain
      IPR026975 Dynein heavy chain 1, axonemal
      IPR024317 Dynein heavy chain, AAA module D4
      IPR035706 Dynein heavy chain, ATP-binding dynein motor region D5
      IPR024743 Dynein heavy chain, coiled coil stalk
      IPR004273 Dynein heavy chain domain
      IPR013602 Dynein heavy chain, domain-2
      IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region D1
      IPR027417 P-loop containing nucleoside triphosphate hydrolase
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 17

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36297, MGI:2442419, MGI:2444537
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 1
      Gene Ontology 7
      Phenotypes 6
    • Earliest
      J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
    • Latest
      J:198514 Raaijmakers JA, et al., Systematic dissection of dynein regulators in mitosis. J Cell Biol. 2013 Apr 15;201(2):201-15

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory