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Dnah1 Gene Detail
Summary
  • Symbol
    Dnah1
  • Name
    dynein, axonemal, heavy chain 1
  • Synonyms
    B230373P09Rik, Dnahc1, E030034C22Rik, MDHC7
  • Feature Type
    protein coding gene
  • IDs
    MGI:107721
    NCBI Gene: 110084
Location & Maps
more
  • Sequence Map
    Chr14:31260375-31323896 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63522 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 19.10 cM
  • Mapping Data
    2 experiments
Homology
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  • Human Ortholog
    DNAH1, dynein axonemal heavy chain 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNAH1, dynein axonemal heavy chain 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    DNAHC1, HDHC7, HL11, HL-11, HSRF-1, XLHSRF-1
  • Links
    NCBI Gene ID: 25981
    neXtProt AC: NX_Q9P2D7

  • Chr Location
    3p21.1; chr3:52316319-52400497 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are male sterile, and show impaired ciliary and flagellar motility that is also observed in the tracheal cilia.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Other Mouse Links
  • Other Vertebrate Links
    Xenbase dnah1
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000019027 Ensembl Gene Model | MGI Sequence Detail 63522 C57BL/6J ±  kb
transcript ENSMUST00000048603 Ensembl | MGI Sequence Detail 12872 Not Applicable  
polypeptide ENSMUSP00000043281 Ensembl | MGI Sequence Detail 4250 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    444 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR011704 ATPase, dynein-related, AAA domain
    IPR026983 Dynein heavy chain
    IPR026975 Dynein heavy chain 1, axonemal
    IPR024743 Dynein heavy chain, coiled coil stalk
    IPR004273 Dynein heavy chain domain
    IPR013602 Dynein heavy chain, domain-2
    IPR024317 Dynein heavy chain, P-loop containing D4 domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 15
    cDNA 15

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36297, MGI:2442419, MGI:2444537
References
more
  • Summaries
    All 26
    Developmental Gene Expression 1
    Gene Ontology 3
    Phenotypes 6
  • Earliest
    J:34934 Vaughan KT, et al., Multiple mouse chromosomal loci for dynein-based motility. Genomics. 1996 Aug 15;36(1):29-38
  • Latest
    J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory