About   Help   FAQ
Myo10 Gene Detail
Summary
  • Symbol
    Myo10
  • Name
    myosin X
  • Synonyms
    D15Ertd600e, mKIAA0799, myosin-X
  • Feature Type
    protein coding gene
  • IDs
    MGI:107716
    NCBI Gene: 17909
  • Gene Overview
    MyGene.info: MYO10
  • Alliance
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:25622550-25813671 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 9.36 cM, cytoband C
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1452 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107716
protein coding gene Chr15:25622525-25813673 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021750
protein coding gene Chr15:23616159-23819000 (+)
A/J MGP_AJ_G0021710
protein coding gene Chr15:22729132-22921260 (+)
AKR/J MGP_AKRJ_G0021688
protein coding gene Chr15:23223432-23423540 (+)
BALB/cJ MGP_BALBcJ_G0021717
protein coding gene Chr15:22710186-22902033 (+)
C3H/HeJ MGP_C3HHeJ_G0021493
protein coding gene Chr15:23266227-23468222 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022156
protein coding gene Chr15:24646813-24847577 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019696
protein coding gene Chr15:21040500-21234057 (+)
CAST/EiJ MGP_CASTEiJ_G0021009
protein coding gene Chr15:23612338-23828028 (+)
CBA/J MGP_CBAJ_G0021462
protein coding gene Chr15:25438921-25645646 (+)
DBA/2J MGP_DBA2J_G0021586
protein coding gene Chr15:22494325-22691104 (+)
FVB/NJ MGP_FVBNJ_G0021564
protein coding gene Chr15:22055980-22249242 (+)
LP/J MGP_LPJ_G0021654
protein coding gene Chr15:23490567-23681581 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021589
protein coding gene Chr15:28134080-28340158 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022179
protein coding gene Chr15:23424240-23620529 (+)
PWK/PhJ MGP_PWKPhJ_G0020752
protein coding gene Chr15:22632455-22830063 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020590
protein coding gene Chr15:23229693-23434246 (+)
WSB/EiJ MGP_WSBEiJ_G0021065
protein coding gene Chr15:23423599-23623679 (+)



Homology
more
  • Human Ortholog
    MYO10, myosin X
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MYO10, myosin X
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4651
    neXtProt AC: NX_Q9HD67
    UniProt: Q9HD67

  • Chr Location
    5p15.1; chr5:16661907-16936276 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutations are semi-lethal with over half of homozygous embryos exhibiting exencephaly. Surviving mutants show decreased body weight, white spotting, syndactyly, persistence of hyaloid vascular system and other eye defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17909 NCBI Gene Model | MGI Sequence Detail 191122 C57BL/6J ±  kb
    transcript NM_019472 RefSeq | MGI Sequence Detail 8098 C57BL/6  
    polypeptide F8VQB6 UniProt | EBI | MGI Sequence Detail 2062 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 22
      Genomic 1
      cDNA 20
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-36292, MGI:1277228, MGI:2146179
    References
    more
    • Summaries
      All 73
      Developmental Gene Expression 9
      Gene Ontology 8
      Phenotypes 26
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:265039 Tokuo H, et al., Myosin X is required for efficient melanoblast migration and melanoma initiation and metastasis. Sci Rep. 2018 Jul 11;8(1):10449

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory