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Myo1f Gene Detail
Summary
  • Symbol
    Myo1f
  • Name
    myosin IF
  • Synonyms
    C330006B10Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107711
    NCBI Gene: 17916
  • Gene Overview
    MyGene.info: MYO1F
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:33555719-33607764 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 17.98 cM, cytoband B-C
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    526 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107711
protein coding gene Chr17:33555707-33607764 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023530
protein coding gene Chr17:33474492-33529544 (+)
A/J MGP_AJ_G0023489
protein coding gene Chr17:32332301-32381267 (+)
AKR/J MGP_AKRJ_G0023455
protein coding gene Chr17:32706839-32758333 (+)
BALB/cJ MGP_BALBcJ_G0023493
protein coding gene Chr17:32477189-32529212 (+)
C3H/HeJ MGP_C3HHeJ_G0023256
protein coding gene Chr17:33043551-33097634 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023937
protein coding gene Chr17:34700319-34761404 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021410
protein coding gene Chr17:29861465-29911901 (+)
CAST/EiJ MGP_CASTEiJ_G0022758
protein coding gene Chr17:33163255-33217957 (+)
CBA/J MGP_CBAJ_G0023232
protein coding gene Chr17:36108291-36174173 (+)
DBA/2J MGP_DBA2J_G0023361
protein coding gene Chr17:31721741-31773127 (+)
FVB/NJ MGP_FVBNJ_G0023330
protein coding gene Chr17:31561600-31615311 (+)
LP/J MGP_LPJ_G0023439
protein coding gene Chr17:33759603-33816108 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023350
protein coding gene Chr17:35173866-35233956 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023977
protein coding gene Chr17:33032577-33084815 (+)
PWK/PhJ MGP_PWKPhJ_G0022506
protein coding gene Chr17:30613180-30664868 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022322
protein coding gene Chr17:31004534-31062025 (+)
WSB/EiJ MGP_WSBEiJ_G0022817
protein coding gene Chr17:33079681-33132056 (+)



Homology
more
  • Human Ortholog
    MYO1F, myosin IF
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MYO1F, myosin IF
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4542
    neXtProt AC: NX_O00160
    UniProt: O00160

  • Chr Location
    19p13.2; chr19:8520790-8577447 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired neutrophil migration and adhesion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000024300 Ensembl Gene Model | MGI Sequence Detail 52046 C57BL/6J ±  kb
transcript ENSMUST00000087605 Ensembl | MGI Sequence Detail 3819 Not Applicable  
polypeptide ENSMUSP00000084887 Ensembl | MGI Sequence Detail 1098 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • InterPro Domains
    IPR036072 Class I myosin, motor domain
    IPR010926 Class I myosin tail homology domain
    IPR000048 IQ motif, EF-hand binding site
    IPR036961 Kinesin motor domain superfamily
    IPR001609 Myosin head, motor domain
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR001452 SH3 domain
    IPR036028 SH3-like domain superfamily
    IPR035507 Unconventional myosin-Ie/If, SH3 domain
Molecular
Reagents
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  • All nucleic 15
    cDNA 14
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36287, MGI:2148238
References
more
  • Summaries
    All 34
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 7
  • Earliest
    J:35477 Hasson T, et al., Mapping of unconventional myosins in mouse and human. Genomics. 1996 Sep 15;36(3):431-9
  • Latest
    J:262075 Salvermoser M, et al., Myosin 1f is specifically required for neutrophil migration in 3D environments during acute inflammation. Blood. 2018 Apr 26;131(17):1887-1898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory