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Itm2a
Gene Detail
Symbol

Name
ID
Itm2a
integral membrane protein 2A
MGI:107706
Synonyms
Bricd2a, Itm2
Feature Type
protein coding gene
Genetic Map
Chromosome X
47.52 cM, cytoband A2-A3
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
ChrX:107397099-107403376 bp, - strand
From VEGA annotation of GRCm38

  6278 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31269  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog

HCOP human homology predictions: ITM2A
Gene Tree: Itm2a

Human
homologs
ITM2A, integral membrane protein 2A
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9452
neXtProt AC: NX_O43736

Human Synonyms: BRICD2A, E25A

Human Chr (Location): Xq13.3-xq21.2; chrX:79360384-79367552 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted allele are viable and fertile with no obvious phenotype.
 
Phenotype Images(1)
Interactions
Itm2a interacts with 166 markers (Mir7-1, Mir10a, Mir10b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (2 annotations)
Component integral component of membrane, membrane
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (44)    Tissues (15)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 6
Northern blot 36
RT-PCR 2
cDNA source data(130)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA ITM2A ; Xenbase itm2a    NEW 
Molecular
reagents
All nucleic(132) Genomic(1) cDNA(130) Primer pair(1)
Microarray probesets(2)
Other database
links
VEGA Gene Model OTTMUSG00000018150 (Evidence)
Ensembl Gene Model ENSMUSG00000031239 (Evidence)
Entrez Gene 16431 (Evidence)
UniGene 193
DFCI TC1572205
DoTS DT.535593
NIA Mouse Gene Index U039633
Consensus CDS Project CCDS30349.1
International Mouse Phenotyping Consortium Status Itm2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018150 VEGA Gene Model | MGI Sequence Detail 6278 C57BL/6J ±  kb
transcript OTTMUST00000043848 VEGA | MGI Sequence Detail 1744 Not Applicable 
polypeptide OTTMUSP00000019690 VEGA | MGI Sequence Detail 263 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007084 BRICHOS domain
Protein Ontology PR:000032694 integral membrane protein 2A
References
(Earliest) J:34815 Deleersnijder W, et al., Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996 Aug 9;271(32):19475-82
(Latest) J:218995 Kihara M, et al., Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. PLoS One. 2014;9(7):e103928
All references(34)
Other
accession IDs
MGD-MRK-36282, MGI:2147997

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory