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Itm2a Gene Detail
Summary
  • Symbol
    Itm2a
  • Name
    integral membrane protein 2A
  • Synonyms
    Bricd2a, Itm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107706
    NCBI Gene: 16431
  • Gene Overview
    MyGene.info: ITM2A
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:107397195-107403360 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.52 cM, cytoband A2-A3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    37 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107706
protein coding gene ChrX:107397099-107403376 (-)
129S1/SvImJ MGP_129S1SvImJ_G0036014
protein coding gene ChrX:104236358-104242522 (-)
A/J MGP_AJ_G0035993
protein coding gene ChrX:104066630-104072841 (-)
AKR/J MGP_AKRJ_G0035912
protein coding gene ChrX:107329606-107335901 (-)
BALB/cJ MGP_BALBcJ_G0035984
protein coding gene ChrX:102821750-102828190 (-)
C3H/HeJ MGP_C3HHeJ_G0035690
protein coding gene ChrX:104707333-104714360 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036510
protein coding gene ChrX:107257260-107264635 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0033338
protein coding gene ChrX:101343356-101349467 (-)
CAST/EiJ MGP_CASTEiJ_G0034977
protein coding gene ChrX:88789376-88797685 (-)
CBA/J MGP_CBAJ_G0035666
protein coding gene ChrX:110616823-110622766 (-)
DBA/2J MGP_DBA2J_G0035820
protein coding gene ChrX:103286531-103292681 (-)
FVB/NJ MGP_FVBNJ_G0035760
protein coding gene ChrX:102634154-102641402 (-)
LP/J MGP_LPJ_G0035912
protein coding gene ChrX:105184908-105191032 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035791
protein coding gene ChrX:115404629-115410407 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036537
protein coding gene ChrX:103803149-103809257 (-)
PWK/PhJ MGP_PWKPhJ_G0034673
protein coding gene ChrX:86331290-86337747 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034502
protein coding gene ChrX:89588095-89594121 (-)
WSB/EiJ MGP_WSBEiJ_G0035115
protein coding gene ChrX:102550799-102557361 (-)



Homology
more
  • Human Ortholog
    ITM2A, integral membrane protein 2A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITM2A, integral membrane protein 2A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BRICD2A, E25A
  • Links
    NCBI Gene ID: 9452
    neXtProt AC: NX_O43736
    UniProt: O43736

  • Chr Location
    Xq21.1; chrX:79360384-79367552 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele are viable and fertile with no obvious phenotype.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16431 NCBI Gene Model | MGI Sequence Detail 6166 C57BL/6J ±  kb
    transcript NM_008409 RefSeq | MGI Sequence Detail 1632 BALB/c  
    polypeptide Q61500 UniProt | EBI | MGI Sequence Detail 263 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 135
      Genomic 1
      cDNA 132
      Primer pair 2

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-36282, MGI:2147997
    References
    more
    • Summaries
      All 35
      Developmental Gene Expression 9
      Gene Ontology 4
      Phenotypes 4
    • Earliest
      J:34815 Deleersnijder W, et al., Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996 Aug 9;271(32):19475-82
    • Latest
      J:218995 Kihara M, et al., Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. PLoS One. 2014;9(7):e103928

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory