About   Help   FAQ
Itm2a Gene Detail
Summary
  • Symbol
    Itm2a
  • Name
    integral membrane protein 2A
  • Synonyms
    Bricd2a, Itm2
  • Feature Type
    protein coding gene
  • IDs
    MGI:107706
    NCBI Gene: 16431
  • Gene Overview
    MyGene.info: ITM2A
Location & Maps
more
  • Sequence Map
    ChrX:107397099-107403376 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6278 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 47.52 cM, cytoband A2-A3
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ITM2A, integral membrane protein 2A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ITM2A, integral membrane protein 2A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BRICD2A, E25A
  • Links
    NCBI Gene ID: 9452
    neXtProt AC: NX_O43736

  • Chr Location
    Xq13.3-Xq21.2; chrX:79360384-79367552 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    1 images
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele are viable and fertile with no obvious phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018150 VEGA Gene Model | MGI Sequence Detail 6278 C57BL/6J ±  kb
transcript OTTMUST00000043848 VEGA | MGI Sequence Detail 1744 Not Applicable  
polypeptide OTTMUSP00000019690 VEGA | MGI Sequence Detail 263 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    37 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000032694 integral membrane protein 2A
  • InterPro Domains
    IPR007084 BRICHOS domain
Molecular
Reagents
less
  • All nucleic 132
    Genomic 1
    cDNA 130
    Primer pair 1

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36282, MGI:2147997
References
more
  • Summaries
    All 33
    Developmental Gene Expression 9
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:34815 Deleersnijder W, et al., Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J Biol Chem. 1996 Aug 9;271(32):19475-82
  • Latest
    J:218995 Kihara M, et al., Itm2a expression in the developing mouse first lower molar, and the subcellular localization of Itm2a in mouse dental epithelial cells. PLoS One. 2014;9(7):e103928

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory