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Abcg1 Gene Detail
Summary
  • Symbol
    Abcg1
  • Name
    ATP binding cassette subfamily G member 1
  • Synonyms
    Abc8, White
  • Feature Type
    protein coding gene
  • IDs
    MGI:107704
    NCBI Gene: 11307
  • Gene Overview
    MyGene.info: ABCG1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:31057698-31115777 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58080 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM, cytoband A2-B
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    ABCG1, ATP binding cassette subfamily G member 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    ABCG1, ATP binding cassette subfamily G member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ABC8, WHITE1
  • Links
    NCBI Gene ID: 9619
    neXtProt AC: NX_P45844
    UniProt: P45844

  • Chr Location
    21q22.3; chr21:42199689-42304389 (+)  GRCh38.p7

Human Diseases
less
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 4 alleles in 6 genetic backgrounds
    22 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal lipid homeostasis, increased numbers of multiple immune cell types, and abnormal response to a high fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000025573 VEGA Gene Model | MGI Sequence Detail 58080 C57BL/6J ±  kb
    transcript OTTMUST00000062902 VEGA | MGI Sequence Detail 3610 Not Applicable  
    polypeptide OTTMUSP00000031072 VEGA | MGI Sequence Detail 666 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      536 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 3
      cDNA 18
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36280, MGI:2147064
    References
    more
    • Summaries
      All 141
      Developmental Gene Expression 9
      Diseases 3
      Gene Ontology 10
      Phenotypes 77
    • Earliest
      J:35459 Savary S, et al., Molecular cloning of a mammalian ABC transporter homologous to Drosophila white gene. Mamm Genome. 1996 Sep;7(9):673-6
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/18/2018
    MGI 6.12
    The Jackson Laboratory