About   Help   FAQ
Casp4 Gene Detail
Summary
  • Symbol
    Casp4
  • Name
    caspase 4, apoptosis-related cysteine peptidase
  • Synonyms
    Casp11, Caspase-11, ich-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107700
    NCBI Gene: 12363
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CASP4, caspase 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CASP4, caspase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX
  • Links
    NCBI Gene ID: 837
    neXtProt AC: NX_P49662

  • Chr Location
    11q22.3; chr11:104942866-104968598 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    53 phenotypes from multigenic genotypes
    43 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Spontaneous
    1
  • Targeted
    5
  • Transgenic
    1
  • Genomic Mutations
    1 involving Casp4
  • Incidental Mutations
Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033830 VEGA Gene Model | MGI Sequence Detail 27956 C57BL/6J ±  kb
transcript OTTMUST00000085221 VEGA | MGI Sequence Detail 1435 Not Applicable  
polypeptide OTTMUSP00000046015 VEGA | MGI Sequence Detail 373 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    162 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 32
    Genomic 1
    cDNA 29
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36276
References
more
  • Summaries
    All 90
    Developmental Gene Expression 9
    Diseases 1
    Gene Ontology 9
    Phenotypes 43
  • Earliest
    J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
  • Latest
    J:234480 Vanaja SK, et al., Bacterial Outer Membrane Vesicles Mediate Cytosolic Localization of LPS and Caspase-11 Activation. Cell. 2016 May 19;165(5):1106-19

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/29/2016
MGI 6.06
The Jackson Laboratory