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Casp4
Gene Detail
Symbol

Name
ID
Casp4
caspase 4, apoptosis-related cysteine peptidase
MGI:107700
Synonyms
Casp11, Caspase-11, ich-3
Feature Type
protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:5308828-5336783 bp, + strand
From VEGA annotation of GRCm38

  27956 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:136493  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle

HCOP human homology predictions: CASP4
Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp4

Human
homologs
CASP4, caspase 4, apoptosis-related cysteine peptidase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 837
neXtProt AC: NX_P49662

Human Synonyms: ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX

Human Chr (Location): 11q22.2-q22.3; chr11:104942866-104968598 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Spontaneous(1) Targeted(5)
Genomic Mutations involving Casp4 (1)
Incidental mutations (data from CvDC )
 
Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Casp4 interacts with 255 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process actin filament organization, apoptotic process, ...
Component AIM2 inflammasome complex, cytoplasm, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (105)    Tissues (66)    Images (25)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 97
RT-PCR 3
RNase protection 5
cDNA source data(28)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(1) cDNA(29) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000033830 (Evidence)
Ensembl Gene Model ENSMUSG00000033538 (Evidence)
Entrez Gene 12363 (Evidence)
UniGene 1569
DFCI TC1581555
DoTS DT.488697, DT.99842299
NIA Mouse Gene Index U010013
EC 3.4.22.64
Consensus CDS Project CCDS22799.1
International Mouse Phenotyping Consortium Status Casp4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033830 VEGA Gene Model | MGI Sequence Detail 27956 C57BL/6J ±  kb
transcript OTTMUST00000085221 VEGA | MGI Sequence Detail 1435 Not Applicable 
polypeptide OTTMUSP00000046015 VEGA | MGI Sequence Detail 373 Not Applicable 

For the selected sequences
All sequences(53) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(166 from dbSNP Build 137)    SNPs within 2kb including multiple locations(168)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002313 caspase-4
References
(Earliest) J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
(Latest) J:222315 Desbien AL, et al., Squalene emulsion potentiates the adjuvant activity of the TLR4 agonist, GLA, via inflammatory caspases, IL-18, and IFN-gamma. Eur J Immunol. 2015 Feb;45(2):407-17
All references(80)
Other
accession IDs
MGD-MRK-36276

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory