Casp4
Gene Detail

Symbol Name ID

Casp4 caspase 4, apoptosis-related cysteine peptidase MGI:107700

Synonyms

Casp11, Caspase-11, ich-3

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:5308828-5336783 bp, + strand From VEGA annotation of GRCm38   27956 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:938  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 5 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp4

Human homologs

Human Homolog		CASP4, caspase 4, apoptosis-related cysteine peptidase
NCBI Gene ID		837
neXtProt AC		NX_P49662
Human Synonyms		ICE(rel)II, ICEREL-II, ICH-2, Mih1/TX, TX
Human Chr (Location)		11q22.2-q22.3; chr11:104813594-104839325 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(4) Spontaneous(1)
 

Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (17 annotations)

Process	apoptotic process, germ cell programmed cell death, ...
Component	intracellular, neuronal cell body, ...
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (105)    Tissues (66)    Images (25)
Theiler Stages: 18, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	97
RT-PCR	3
RNase protection	5

cDNA source data(27)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(31) Genomic(1) cDNA(28) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000033830 (Evidence)
Ensembl Gene Model	ENSMUSG00000033538 (Evidence)
Entrez Gene	12363 (Evidence)
UniGene	1569
DFCI	TC1581555
DoTS	DT.488697, DT.99842299
NIA Mouse Gene Index	U010013
EC	3.4.22.64
Consensus CDS Project	CCDS22799.1
International Mouse Knockout Project Status	Casp4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033830	VEGA Gene Model | MGI Sequence Detail	27956	C57BL/6J
transcript	OTTMUST00000085221	VEGA | MGI Sequence Detail	1435	Not Applicable
polypeptide	OTTMUSP00000046015	VEGA | MGI Sequence Detail	373	Not Applicable

All sequences(47) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(148 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017350	Caspase, interleukin-1 beta convertase
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	Death-like domain
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR002398	Peptidase C14, caspase precursor p45
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000002313	caspase-4

References

(Earliest) J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
(Latest) J:193387 Aachoui Y, et al., Caspase-11 protects against bacteria that escape the vacuole. Science. 2013 Feb 22;339(6122):975-8
All references(66)

Other accession IDs

MGD-MRK-36276