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Casp4 Gene Detail
Summary
  • Symbol
    Casp4
  • Name
    caspase 4, apoptosis-related cysteine peptidase
  • Synonyms
    Casp11, Caspase-11, ich-3
  • Feature Type
    protein coding gene
  • IDs
    MGI:107700
    NCBI Gene: 12363
  • Alliance
Location & Maps
more
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CASP4, caspase 4
  • Vertebrate Orthologs
    6
  • Human Ortholog
    CASP4, caspase 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ICE(rel)II, ICEREL-II, ICH-2, Mih1, Mih1/TX, TX
  • Links
    NCBI Gene ID: 837
    neXtProt AC: NX_P49662
    UniProt: P49662

  • Chr Location
    11q22.3; chr11:104942866-104968598 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotypes from 3 alleles in 3 genetic backgrounds
    53 phenotypes from multigenic genotypes
    63 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased levels of serum IL-1alpha and IL-1beta. Mutant animals are resistant to septic shock after injection with LPS.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000033830 VEGA Gene Model | MGI Sequence Detail 27956 C57BL/6J ±  kb
    transcript OTTMUST00000085221 VEGA | MGI Sequence Detail 1435 Not Applicable  
    polypeptide OTTMUSP00000046015 VEGA | MGI Sequence Detail 373 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      162 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 35
      Genomic 1
      cDNA 30
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-36276
    References
    more
    • Summaries
      All 131
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 9
      Phenotypes 63
    • Earliest
      J:34885 Wang S, et al., Identification and characterization of Ich-3, a member of the interleukin-1beta converting enzyme (ICE)/Ced-3 family and an upstream regulator of ICE. J Biol Chem. 1996 Aug 23;271(34):20580-7
    • Latest
      J:261112 Place DE, et al., ASK Family Kinases Are Required for Optimal NLRP3 Inflammasome Priming. Am J Pathol. 2018 Apr;188(4):1021-1030

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory