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Usp17lc Gene Detail
Summary
  • Symbol
    Usp17lc
  • Name
    ubiquitin specific peptidase 17-like C
  • Synonyms
    Dub2, Dub-2, Dub2b, Usp17l5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107698
    NCBI Gene: 13532
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:103065903-103068381 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    10
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107698
protein coding gene Chr7:103064279-103069087 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032648
protein coding gene Chr7:106339972-106350243 (-)
A/J MGP_AJ_G0032703
protein coding gene Chr7:105216382-105219713 (+)
AKR/J MGP_AKRJ_G0032638
protein coding gene Chr7:107892999-107904224 (+)
BALB/cJ MGP_BALBcJ_G0032643
protein coding gene Chr7:103558131-103563145 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033212
protein coding gene Chr7:112182976-112185212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030203
protein coding gene Chr7:107215150-107217616 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0032393
protein coding gene Chr7:115927159-115930352 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0032500
protein coding gene Chr7:103231734-103262939 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0031309
protein coding gene Chr7:93939479-93952351 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Vertebrate Orthologs
    29
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    USP17L1, ubiquitin specific peptidase 17 like family member 1
  • Synonyms
    USP17L1P
  • Links
    NCBI Gene ID: 401447
    neXtProt AC: NX_Q7RTZ2
    UniProt: Q7RTZ2

  • Chr Location
    8p23.1; chr8:7332387-7333979 (+)  GRCh38.p7

  • Human Ortholog
    USP17L10, ubiquitin specific peptidase 17 like family member 10
  • Links
    NCBI Gene ID: 100287144
    neXtProt AC: NX_C9JJH3
    UniProt: C9JJH3

  • Chr Location
    chr4:9210657-9212249 (+)  GRCh38.p7

  • Human Ortholog
    USP17L11, ubiquitin specific peptidase 17 like family member 11
  • Links
    NCBI Gene ID: 100287178
    neXtProt AC: NX_C9JVI0
    UniProt: C9JVI0

  • Chr Location
    chr4:9215405-9216997 (+)  GRCh38.p7

  • Human Ortholog
    USP17L12, ubiquitin specific peptidase 17 like family member 12
  • Links
    NCBI Gene ID: 100287205
    neXtProt AC: NX_C9JPN9
    UniProt: C9JPN9

  • Chr Location
    chr4:9220152-9221744 (+)  GRCh38.p7

  • Human Ortholog
    USP17L13, ubiquitin specific peptidase 17 like family member 13
  • Links
    NCBI Gene ID: 100287238
    neXtProt AC: NX_C9JLJ4
    UniProt: C9JLJ4

  • Chr Location
    chr4:9224896-9226488 (+)  GRCh38.p7

  • Human Ortholog
    USP17L15, ubiquitin specific peptidase 17 like family member 15
  • Links
    NCBI Gene ID: 100288520
    UniProt: C9J2P7

  • Chr Location
    chr4:9234385-9236334 (+)  GRCh38.p7

  • Human Ortholog
    USP17L17, ubiquitin specific peptidase 17 like family member 17
  • Links
    NCBI Gene ID: 100287327
    neXtProt AC: NX_D6RBQ6
    UniProt: D6RBQ6

  • Chr Location
    chr4:9243879-9245471 (+)  GRCh38.p7

  • Human Ortholog
    USP17L18, ubiquitin specific peptidase 17 like family member 18
  • Links
    NCBI Gene ID: 100287364
    neXtProt AC: NX_D6R9N7
    UniProt: D6R9N7

  • Chr Location
    chr4:9248630-9250222 (+)  GRCh38.p7

  • Human Ortholog
    USP17L19, ubiquitin specific peptidase 17 like family member 19
  • Links
    NCBI Gene ID: 100287404
    neXtProt AC: NX_D6RCP7
    UniProt: D6RCP7

  • Chr Location
    chr4:9253378-9254970 (+)  GRCh38.p7

  • Human Ortholog
    USP17L2, ubiquitin specific peptidase 17 like family member 2
  • Synonyms
    DUB3, DUB-3, USP17
  • Links
    NCBI Gene ID: 377630
    neXtProt AC: NX_Q6R6M4
    UniProt: Q6R6M4

  • Chr Location
    8p23.1; chr8:12137168-12138760 (-)  GRCh38.p7

  • Human Ortholog
    USP17L20, ubiquitin specific peptidase 17 like family member 20
  • Links
    NCBI Gene ID: 100287441
    neXtProt AC: NX_D6RJB6
    UniProt: D6RJB6

  • Chr Location
    chr4:9258124-9259716 (+)  GRCh38.p7

  • Human Ortholog
    USP17L21, ubiquitin specific peptidase 17 like family member 21
  • Links
    NCBI Gene ID: 100287478
    neXtProt AC: NX_D6R901
    UniProt: D6R901

  • Chr Location
    chr4:9262872-9264464 (+)  GRCh38.p7

  • Human Ortholog
    USP17L22, ubiquitin specific peptidase 17 like family member 22
  • Links
    NCBI Gene ID: 100287513
    neXtProt AC: NX_D6RA61
    UniProt: D6RA61

  • Chr Location
    chr4:9267619-9269211 (+)  GRCh38.p7


  • Human Ortholog
    USP17L24, ubiquitin specific peptidase 17 like family member 24
  • Synonyms
    USP17L25, USP17L26, USP17L27, USP17L28, USP17L29, USP17L30
  • Links
    NCBI Gene ID: 728369
    neXtProt AC: NX_Q0WX57
    UniProt: Q0WX57

  • Chr Location
    4p16.1; chr4:9325165-9326757 (+)  GRCh38.p7

  • Human Ortholog
    USP17L25, ubiquitin specific peptidase 17 like family member 25
  • Links
    NCBI Gene ID: 728373
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9329911-9331503 (+)  GRCh38.p7

  • Human Ortholog
    USP17L26, ubiquitin specific peptidase 17 like family member 26
  • Links
    NCBI Gene ID: 728379
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9334658-9336250 (+)  GRCh38.p7

  • Human Ortholog
    USP17L27, ubiquitin specific peptidase 17 like family member 27
  • Links
    NCBI Gene ID: 728393
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9344148-9345740 (+)  GRCh38.p7

  • Human Ortholog
    USP17L28, ubiquitin specific peptidase 17 like family member 28
  • Links
    NCBI Gene ID: 728400
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9348893-9350485 (+)  GRCh38.p7

  • Human Ortholog
    USP17L29, ubiquitin specific peptidase 17 like family member 29
  • Links
    NCBI Gene ID: 728405
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9353638-9355230 (+)  GRCh38.p7

  • Human Ortholog
    USP17L3, ubiquitin specific peptidase 17 like family member 3
  • Synonyms
    USP17B, USP17F
  • Links
    NCBI Gene ID: 645836
    neXtProt AC: NX_A6NCW0
    UniProt: A6NCW0

  • Chr Location
    8p23.1; chr8:7976393-7977985 (-)  GRCh38.p7

  • Human Ortholog
    USP17L30, ubiquitin specific peptidase 17 like family member 30
  • Links
    NCBI Gene ID: 728419
    neXtProt AC: NX_Q0WX57

  • Chr Location
    4p16.1; chr4:9363129-9364721 (+)  GRCh38.p7

  • Human Ortholog
    USP17L4, ubiquitin specific peptidase 17 like family member 4
  • Links
    NCBI Gene ID: 645402
    neXtProt AC: NX_A6NCW7
    UniProt: A6NCW7

  • Chr Location
    8p23.1; chr8:7337115-7338707 (+)  GRCh38.p7

  • Human Ortholog
    USP17L5, ubiquitin specific peptidase 17 like family member 5
  • Links
    NCBI Gene ID: 728386
    neXtProt AC: NX_A8MUK1
    UniProt: A8MUK1

  • Chr Location
    4p16.1; chr4:9339403-9340995 (+)  GRCh38.p7

  • Human Ortholog
    USP17L6P, ubiquitin specific peptidase 17 like family member 6, pseudogene
  • Synonyms
    DUB4, USP17L6, vDUB4
  • Links
    NCBI Gene ID: 391622
    UniProt: Q6QN14

  • Chr Location
    4p16.1; chr4:9367874-9369070 (+)  GRCh38.p7

  • Human Ortholog
    USP17L7, ubiquitin specific peptidase 17 like family member 7
  • Links
    NCBI Gene ID: 392197
    neXtProt AC: NX_P0C7H9
    UniProt: P0C7H9

  • Chr Location
    8p23.1; chr8:12132417-12134009 (-)  GRCh38.p7

  • Human Ortholog
    USP17L8, ubiquitin specific peptidase 17 like family member 8
  • Synonyms
    USP17L10
  • Links
    NCBI Gene ID: 392188
    neXtProt AC: NX_P0C7I0
    UniProt: P0C7I0

  • Chr Location
    8p23.1; chr8:7971661-7973253 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic elthality before implantation, failure to hatch from the zona pellucida, decreased cell proliferation and increased apoptosis. Mice heterozygous for this allele exhibit abnormal body, testis and thymus weight and reduced sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • cDNA Data
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13532 NCBI Gene Model | MGI Sequence Detail 2479 C57BL/6J ±  kb
    transcript NM_010089 RefSeq | MGI Sequence Detail 1697 Not Specified  
    polypeptide G5E8I7 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • EC
    • InterPro Domains
      IPR038765 Papain-like cysteine peptidase superfamily
      IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
      IPR018200 Ubiquitin specific protease, conserved site
      IPR028889 Ubiquitin specific protease domain
    Molecular
    Reagents
    less
    • All nucleic 3
      Genomic 2
      cDNA 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36274
    References
    more
    • Summaries
      All 31
      Gene Ontology 6
      Phenotypes 12
    • Earliest
      J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
    • Latest
      J:191761 Baek KH, et al., Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. PLoS One. 2012;7(9):e44223

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    last database update
    09/13/2022
    MGI 6.21
    The Jackson Laboratory