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Usp17lc Gene Detail
Summary
  • Symbol
    Usp17lc
  • Name
    ubiquitin specific peptidase 17-like C
  • Synonyms
    Dub2, Dub-2, Dub2b, Usp17l5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107698
    NCBI Gene: 13532
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr7:103416696-103419174 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 54.85 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    53 from dbSNP Build 142
  • Strain Annotations
    10
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107698
protein coding gene Chr7:103415072-103419880 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032648
protein coding gene Chr7:106339972-106350243 (-)
A/J MGP_AJ_G0032703
protein coding gene Chr7:105216382-105219713 (+)
AKR/J MGP_AKRJ_G0032638
protein coding gene Chr7:107892999-107904224 (+)
BALB/cJ MGP_BALBcJ_G0032643
protein coding gene Chr7:103558131-103563145 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0033212
protein coding gene Chr7:112182976-112185212 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0030203
protein coding gene Chr7:107215150-107217616 (-)
CAST/EiJ no annotation
CBA/J MGP_CBAJ_G0032393
protein coding gene Chr7:115927159-115930352 (-)
DBA/2J no annotation
FVB/NJ MGP_FVBNJ_G0032500
protein coding gene Chr7:103231734-103262939 (+)
LP/J no annotation
NOD/ShiLtJ no annotation
NZO/HlLtJ no annotation
PWK/PhJ no annotation
SPRET/EiJ MGP_SPRETEiJ_G0031309
protein coding gene Chr7:93939479-93952351 (+)
WSB/EiJ no annotation



Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    1 images
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Usp17lc
  • Incidental Mutations
    APF
  • Find Mice (IMSR)
Mice homozygous for a knock-out allele exhibit embryonic elthality before implantation, failure to hatch from the zona pellucida, decreased cell proliferation and increased apoptosis. Mice heterozygous for this allele exhibit abnormal body, testis and thymus weight and reduced sperm motility.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13532 NCBI Gene Model | MGI Sequence Detail 2479 C57BL/6J ±  kb
transcript NM_010089 RefSeq | MGI Sequence Detail 1697 Not Specified  
polypeptide G5E8I7 UniProt | EBI | MGI Sequence Detail 545 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • EC
  • InterPro Domains
    IPR038765 Papain-like cysteine peptidase superfamily
    IPR001394 Peptidase C19, ubiquitin carboxyl-terminal hydrolase
    IPR018200 Ubiquitin specific protease, conserved site
    IPR028889 Ubiquitin specific protease domain
Molecular
Reagents
less
  • All nucleic 3
    Genomic 2
    cDNA 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36274
References
more
  • Summaries
    All 32
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:191761 Baek KH, et al., Embryonic demise caused by targeted disruption of a cysteine protease Dub-2. PLoS One. 2012;7(9):e44223

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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Funding Information
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last database update
12/03/2019
MGI 6.14
The Jackson Laboratory