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Mdfi Gene Detail
Summary
  • Symbol
    Mdfi
  • Name
    MyoD family inhibitor
  • Synonyms
    I-mf, I-mfa
  • Feature Type
    protein coding gene
  • IDs
    MGI:107687
    NCBI Gene: 17240
  • Gene Overview
    MyGene.info: MDFI
  • Alliance
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:47815328-47834691 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 23.99 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107687
protein coding gene Chr17:47815328-47834691 (-)
129S1/SvImJ MGP_129S1SvImJ_G0023858
protein coding gene Chr17:49041700-49070571 (-)
A/J MGP_AJ_G0023818
protein coding gene Chr17:47769828-47788794 (-)
AKR/J MGP_AKRJ_G0023787
protein coding gene Chr17:48189868-48211328 (-)
BALB/cJ MGP_BALBcJ_G0023820
protein coding gene Chr17:47685050-47705702 (-)
C3H/HeJ MGP_C3HHeJ_G0023583
protein coding gene Chr17:48925639-48945947 (-)
C57BL/6NJ MGP_C57BL6NJ_G0024264
protein coding gene Chr17:51083893-51112404 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0021713
protein coding gene Chr17:44525693-44544448 (-)
CAST/EiJ MGP_CASTEiJ_G0023065
protein coding gene Chr17:49039715-49067948 (-)
CBA/J MGP_CBAJ_G0023560
protein coding gene Chr17:52943696-52966274 (-)
DBA/2J MGP_DBA2J_G0023688
protein coding gene Chr17:46524154-46543339 (-)
FVB/NJ MGP_FVBNJ_G0023654
protein coding gene Chr17:46184686-46205702 (-)
LP/J MGP_LPJ_G0023768
protein coding gene Chr17:49692743-49712962 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0023682
protein coding gene Chr17:52406204-52426091 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0024309
protein coding gene Chr17:48545762-48570412 (-)
PWK/PhJ MGP_PWKPhJ_G0022810
protein coding gene Chr17:45905380-45927153 (-)
SPRET/EiJ MGP_SPRETEiJ_G0022625
protein coding gene Chr17:45435609-45458202 (-)
WSB/EiJ MGP_WSBEiJ_G0023130
protein coding gene Chr17:49134130-49155243 (-)



Homology
more
  • Human Ortholog
    MDFI, MyoD family inhibitor
  • Vertebrate Orthologs
    11
  • Human Ortholog
    MDFI, MyoD family inhibitor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    I-MF, I-mfa
  • Links
    NCBI Gene ID: 4188
    neXtProt AC: NX_Q99750
    UniProt: Q99750

  • Chr Location
    6p21.1; chr6:41637020-41654246 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 21150
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;2 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MDFI
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation on a C57BL/6 background exhibit a placental defect and die around embryonic day 10.5, but on a 129/Sv background, mutants survive to adulthood and show delayed caudal neural tube closure and skeletal abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 17240 NCBI Gene Model | MGI Sequence Detail 19364 C57BL/6J ±  kb
    transcript NM_001109973 RefSeq | MGI Sequence Detail 1711 C57BL/6  
    polypeptide P70331 UniProt | EBI | MGI Sequence Detail 251 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 40
      cDNA 38
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36262
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 8
      Gene Ontology 8
      Phenotypes 7
    • Earliest
      J:35246 Chen CM, et al., I-mf, a novel myogenic repressor, interacts with members of the MyoD family. Cell. 1996 Sep 6;86(5):731-41
    • Latest
      J:242847 Nair RR, et al., Genetic modifications of Mecr reveal a role for mitochondrial 2-enoyl-CoA/ACP reductase in placental development in mice. Hum Mol Genet. 2017 Jun 01;26(11):2104-2117

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory