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Plxna1
Gene Detail
 Symbol
Name
ID
Plxna1
plexin A1
MGI:107685
Synonyms 2600013D04Rik, NOV, PlexA1, Plxn1
Feature Type protein coding gene
Genetic Map
Chromosome 6
39.91 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr6:89316316-89362613 bp, - strand
From Ensembl annotation of GRCm38

  46298 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Plxna1

Human
homologs
Human Homolog PLXNA1, plexin A1
NCBI Gene ID 5361
neXtProt AC  NX_Q9UIW2
Human Synonyms  NOV, NOVP, PLEXIN-A1, PLXN1
Human Chr (Location)  3q21.3; chr3:126988521-127037392 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit bone cellularity abnormalities, altered dendritic cell physiology, and abnormal proprioceptive and oligodendrocyte morphology.
 
Interactions
Plxna1 interacts with 359 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process dichotomous subdivision of terminal units involved in salivary gland branching, multicellular organismal development, ...
Component cytoplasm, extracellular vesicular exosome, ...
Function protein binding, receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (166)    Tissues (124)    Images (30)
Theiler Stages: 2, 3, 4, 5, 16, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 151
Northern blot 7
RT-PCR 8
cDNA source data(198)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(202) cDNA(200) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000030084 (Evidence)
Entrez Gene18844 (Evidence)
UniGene3789
DFCITC1576487, TC1617832
DoTSDT.99852404
NIA Mouse Gene IndexU027603
PDB3RYT
Consensus CDS ProjectCCDS20344.1
International Mouse Knockout Project StatusPlxna1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030084 Ensembl Gene Model | MGI Sequence Detail 46298 C57BL/6J ±  kb
transcript ENSMUST00000163139 Ensembl | MGI Sequence Detail 9025 Not Applicable 
polypeptide ENSMUSP00000131840 Ensembl | MGI Sequence Detail 1894 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms SNPs within 2kb(258 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR002165 Plexin
InterPro IPR013548 Plexin, cytoplasmic RasGAP domain
InterPro IPR016201 Plexin-like fold
InterPro IPR008936 Rho GTPase activation protein
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000012892 plexin-A1
References (Earliest) J:35259 Kameyama T, et al., Identification of plexin family molecules in mice. Biochem Biophys Res Commun. 1996 Sep 13;226(2):396-402
(Latest) J:205955 Katayama K, et al., Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. PLoS One. 2013;8(8):e72512
All references(80)
Other
accession IDs
MGD-MRK-36260, MGI:1917296

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory