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Plxna3 Gene Detail
Summary
  • Symbol
    Plxna3
  • Name
    plexin A3
  • Synonyms
    PlexA3, Plxa3, Plxn3, Plxn4, SEX
  • Feature Type
    protein coding gene
  • IDs
    MGI:107683
    NCBI Gene: 18846
  • Gene Overview
    MyGene.info: PLXNA3
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:74329066-74344689 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 38.00 cM, cytoband B-C1
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    42 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107683
protein coding gene ChrX:74329050-74344689 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035842
protein coding gene ChrX:70131616-70147236 (+)
A/J MGP_AJ_G0035823
protein coding gene ChrX:70313262-70328882 (+)
AKR/J MGP_AKRJ_G0035748
protein coding gene ChrX:72215086-72230792 (+)
BALB/cJ MGP_BALBcJ_G0035808
protein coding gene ChrX:69340287-69355909 (+)
C3H/HeJ MGP_C3HHeJ_G0035513
protein coding gene ChrX:70604183-70619798 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036338
protein coding gene ChrX:72292147-72307766 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033182
protein coding gene ChrX:69379596-69395235 (+)
CAST/EiJ MGP_CASTEiJ_G0034804
protein coding gene ChrX:55985885-56001526 (+)
CBA/J MGP_CBAJ_G0035488
protein coding gene ChrX:74289273-74304889 (+)
DBA/2J MGP_DBA2J_G0035645
protein coding gene ChrX:69773142-69788756 (+)
FVB/NJ MGP_FVBNJ_G0035589
protein coding gene ChrX:69117256-69132880 (+)
LP/J MGP_LPJ_G0035730
protein coding gene ChrX:70907833-70923456 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035627
protein coding gene ChrX:76850806-76866412 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036360
protein coding gene ChrX:69946801-69962420 (+)
PWK/PhJ MGP_PWKPhJ_G0034503
protein coding gene ChrX:53945959-53961565 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034337
protein coding gene ChrX:56852712-56868335 (+)
WSB/EiJ MGP_WSBEiJ_G0034945
protein coding gene ChrX:69230669-69246288 (+)



Homology
more
  • Human Ortholog
    PLXNA3, plexin A3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    PLXNA3, plexin A3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    6.3, HSSEXGENE, PLXN3, PLXN4, XAP-6
  • Links
    NCBI Gene ID: 55558
    neXtProt AC: NX_P51805
    UniProt: P51805

  • Chr Location
    Xq28; chrX:154458281-154473646 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 2 genetic backgrounds
    11 phenotypes from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene possess misdirected axons in the hippocampus. They are, otherwise, indistinguishable from wild-type mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000031398 Ensembl Gene Model | MGI Sequence Detail 15624 C57BL/6J ±  kb
    transcript ENSMUST00000004326 Ensembl | MGI Sequence Detail 6943 Not Applicable  
    polypeptide ENSMUSP00000004326 Ensembl | MGI Sequence Detail 1872 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      Genomic 1
      cDNA 82
      Primer pair 2
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36258, MGD-MRK-39626, MGI:109627
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 41
      Gene Ontology 9
      Phenotypes 23
    • Earliest
      J:26634 Rivella S, et al., A comparative transcriptional map of a region of 250 kb on the human and mouse X chromosome between the G6PD and the FLN1 genes. Genomics. 1995 Aug 10;28(3):377-82
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory