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Slc5a1 Gene Detail
Summary
  • Symbol
    Slc5a1
  • Name
    solute carrier family 5 (sodium/glucose cotransporter), member 1
  • Synonyms
    Sglt1, sodium glucose cotransporter 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107678
    NCBI Gene: 20537
  • Gene Overview
    MyGene.info: SLC5A1
Location & Maps
more
  • Sequence Map
    Chr5:33104219-33162870 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      58652 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 17.46 cM, cytoband B1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SLC5A1, solute carrier family 5 member 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC5A1, solute carrier family 5 member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    D22S675, NAGT, SGLT1
  • Links
    NCBI Gene ID: 6523
    neXtProt AC: NX_P13866

  • Chr Location
    22q12.3; chr22:32043032-32113029 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Slc5a1 mouse models; 1 with human SLC5A1 associations

Human Disease Mouse Models
       Glucose/Galactose Malabsorption; GGM   OMIM: 606824 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    2
  • Gene trapped
    17
  • Radiation induced
    3
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    7 involving Slc5a1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027971 VEGA Gene Model | MGI Sequence Detail 58652 C57BL/6J ±  kb
transcript OTTMUST00000069291 VEGA | MGI Sequence Detail 4104 Not Applicable  
polypeptide OTTMUSP00000035171 VEGA | MGI Sequence Detail 665 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    284 from dbSNP Build 142
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000015165 sodium/glucose cotransporter 1
  • InterPro Domains
    IPR001734 Sodium/solute symporter
    IPR018212 Sodium/solute symporter, conserved site
Molecular
Reagents
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  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36253
References
more
  • Summaries
    All 51
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 9
    Phenotypes 32
  • Earliest
    J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
  • Latest
    J:228070 Dominguez Rieg JA, et al., Regulation of intestinal SGLT1 by catestatin in hyperleptinemic type 2 diabetic mice. Lab Invest. 2016 Jan;96(1):98-111

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory