Slc5a1
Gene Detail

Symbol Name ID

Slc5a1 solute carrier family 5 (sodium/glucose cotransporter), member 1 MGI:107678

Synonyms

Sglt1, sodium glucose cotransporter 1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

17.46 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:33104219-33162872 bp, + strand From VEGA annotation of GRCm38   58654 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Slc5a1

Human homologs

Human Homolog		SLC5A1, solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Gene ID		6523
neXtProt AC		NX_P13866
Human Synonyms		D22S675, NAGT, SGLT1
Human Chr (Location)		22q12.3; chr22:32439019-32509016 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SLC5A1

Alleles and phenotypes

All alleles(20) : Targeted(3) Gene trapped(17)
 

Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption.

 
Human Diseases Modeled Using Mouse Slc5a1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	carbohydrate transport, glucose transport, ...
Component	apical plasma membrane, brush border, ...
Function	glucose:sodium symporter activity, glucose transmembrane transporter activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (169)    Tissues (109)    Images (34)
Theiler Stages: 21, 22, 23, 24, 28

Assay Type	Results
Immunohistochemistry	13
RNA in situ	150
Northern blot	6

cDNA source data(31)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000027971 (Evidence)
Ensembl Gene Model	ENSMUSG00000011034 (Evidence)
Entrez Gene	20537 (Evidence)
UniGene	25237
DFCI	TC1580568
DoTS	DT.490274
NIA Mouse Gene Index	U005469
Consensus CDS Project	CCDS19199.1
International Mouse Knockout Project Status	Slc5a1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000027971	VEGA Gene Model | MGI Sequence Detail	58654	C57BL/6J
transcript	OTTMUST00000069291	VEGA | MGI Sequence Detail	4106	Not Applicable
polypeptide	OTTMUSP00000035171	VEGA | MGI Sequence Detail	665	Not Applicable

All sequences(27) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(197 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001734	Sodium/solute symporter
InterPro	IPR018212	Sodium/solute symporter, conserved site
InterPro	IPR019900	Sodium/solute symporter, subgroup
Protein Ontology	PR:000015165	sodium/glucose cotransporter 1

References

(Earliest) J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
(Latest) J:186790 Gorboulev V, et al., Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 2012 Jan;61(1):187-96
All references(47)

Other accession IDs

MGD-MRK-36253