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Slc5a1
Gene Detail
 Symbol
Name
ID
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
MGI:107678
Synonyms Sglt1, sodium glucose cotransporter 1
Feature Type protein coding gene
Genetic Map
Chromosome 5
17.46 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:33104219-33162872 bp, + strand
From VEGA annotation of GRCm38

  58654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Gene Tree: Slc5a1

Human
homologs
Human Homolog SLC5A1, solute carrier family 5 (sodium/glucose cotransporter), member 1
NCBI Gene ID 6523
neXtProt AC  NX_P13866
Human Synonyms  D22S675, NAGT, SGLT1
Human Chr (Location)  22q12.3; chr22:32043032-32113029 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human SLC5A1
Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Chemically induced (ENU)(1) Gene trapped(17) Radiation induced(2) Targeted(3)
Genomic Mutations involving Slc5a1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption.
 
Human Diseases Modeled Using Mouse Slc5a1 (1)    Alleles Annotated to Human Diseases(3)   
Interactions
Slc5a1 interacts with 213 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process carbohydrate transport, glucose transport, ...
Component apical plasma membrane, brush border, ...
Function glucose:sodium symporter activity, glucose transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (237)    Tissues (178)    Images (36)
Theiler Stages: 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
Immunohistochemistry 13
RNA in situ 218
Northern blot 6
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000027971 (Evidence)
Ensembl Gene ModelENSMUSG00000011034 (Evidence)
Entrez Gene20537 (Evidence)
UniGene25237
DFCITC1580568
DoTSDT.490274
NIA Mouse Gene IndexU005469
Consensus CDS ProjectCCDS19199.1
International Mouse Knockout Project StatusSlc5a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027971 VEGA Gene Model | MGI Sequence Detail 58654 C57BL/6J ±  kb
transcript OTTMUST00000069291 VEGA | MGI Sequence Detail 4106 Not Applicable 
polypeptide OTTMUSP00000035171 VEGA | MGI Sequence Detail 665 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015165 sodium/glucose cotransporter 1
References (Earliest) J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
(Latest) J:205119 Rieg T, et al., Increase in SGLT1-mediated transport explains renal glucose reabsorption during genetic and pharmacological SGLT2 inhibition in euglycemia. Am J Physiol Renal Physiol. 2014 Jan;306(2):F188-93
All references(52)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory