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Slc5a1
Gene Detail
Symbol

Name
ID
Slc5a1
solute carrier family 5 (sodium/glucose cotransporter), member 1
MGI:107678
Synonyms
Sglt1, sodium glucose cotransporter 1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
17.46 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:33104219-33162870 bp, + strand
From VEGA annotation of GRCm38

  58652 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55456  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC5A1
Gene Tree: Slc5a1

Human
homologs
SLC5A1, solute carrier family 5 (sodium/glucose cotransporter), member 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6523
neXtProt AC: NX_P13866

Human Synonyms: D22S675, NAGT, SGLT1

Human Chr (Location): 22q12.3; chr22:32043032-32113029 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SLC5A1

Mutations,
alleles, and
phenotypes
All mutations/alleles(24) : Chemically induced (ENU)(1) Gene trapped(17) Radiation induced(3) Targeted(3)
Genomic Mutations involving Slc5a1 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit lethality unless maintained on a glucose-galatose-free diet, distended intestine, impaired glucose transport across the brush border membrane and impaired renal glucose reabsorption.
 
Human Diseases Modeled in Mice Using Slc5a1 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(4)
Interactions
Slc5a1 interacts with 213 markers (Mir7-1, Mir10a, Mir17, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (26 annotations)
Process carbohydrate transport, glucose transport, ...
Component apical plasma membrane, brush border, ...
Function glucose:sodium symporter activity, glucose transmembrane transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (237)    Tissues (178)    Images (36)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 13
RNA in situ 218
Northern blot 6
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100498135 ; ZFIN slc5a1    NEW 
Molecular
reagents
All nucleic(34) cDNA(33) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000027971 (Evidence)
Ensembl Gene Model ENSMUSG00000011034 (Evidence)
Entrez Gene 20537 (Evidence)
UniGene 25237
DFCI TC1580568
DoTS DT.490274
NIA Mouse Gene Index U005469
Consensus CDS Project CCDS19199.1
International Mouse Phenotyping Consortium Status Slc5a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027971 VEGA Gene Model | MGI Sequence Detail 58652 C57BL/6J ±  kb
transcript OTTMUST00000069291 VEGA | MGI Sequence Detail 4104 Not Applicable 
polypeptide OTTMUSP00000035171 VEGA | MGI Sequence Detail 665 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(291 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001734 Sodium/solute symporter
InterPro IPR018212 Sodium/solute symporter, conserved site
InterPro IPR019900 Sodium/solute symporter, subgroup
Protein Ontology PR:000015165 sodium/glucose cotransporter 1
References
(Earliest) J:35094 Wiley LM, et al., Antibodies to a renal Na+/glucose cotransport system localize to the apical plasma membrane domain of polar mouse embryo blastomeres. Dev Biol. 1991 Jan;143(1):149-61
(Latest) J:214475 Roder PV, et al., The role of SGLT1 and GLUT2 in intestinal glucose transport and sensing. PLoS One. 2014;9(2):e89977
All references(51)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory