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Tank Gene Detail
Summary
  • Symbol
    Tank
  • Name
    TRAF family member-associated Nf-kappa B activator
  • Synonyms
    E430026L09Rik, I-TRAF
  • Feature Type
    protein coding gene
  • IDs
    MGI:107676
    NCBI Gene: 21353
  • Gene Overview
    MyGene.info: TANK
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:61578585-61654171 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 35.56 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    254 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107676
protein coding gene Chr2:61578560-61654171 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025765
protein coding gene Chr2:61241551-61319924 (+)
A/J MGP_AJ_G0025741
protein coding gene Chr2:58890159-58966074 (+)
AKR/J MGP_AKRJ_G0025711
protein coding gene Chr2:60476399-60555486 (+)
BALB/cJ MGP_BALBcJ_G0025736
protein coding gene Chr2:58994055-59070030 (+)
C3H/HeJ MGP_C3HHeJ_G0025497
protein coding gene Chr2:60582454-60656889 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026183
protein coding gene Chr2:63036659-63116077 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023587
protein coding gene Chr2:56395473-56469077 (+)
CAST/EiJ MGP_CASTEiJ_G0024961
protein coding gene Chr2:60646804-60729868 (+)
CBA/J MGP_CBAJ_G0025477
protein coding gene Chr2:65421830-65497199 (+)
DBA/2J MGP_DBA2J_G0025608
protein coding gene Chr2:58457347-58538704 (+)
FVB/NJ MGP_FVBNJ_G0025570
protein coding gene Chr2:57996850-58072051 (+)
LP/J MGP_LPJ_G0025696
protein coding gene Chr2:61068577-61146530 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025601
protein coding gene Chr2:67012013-67107776 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026240
protein coding gene Chr2:60522734-60599553 (+)
PWK/PhJ MGP_PWKPhJ_G0024702
protein coding gene Chr2:58328772-58415284 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024509
protein coding gene Chr2:60647391-60731245 (+)
WSB/EiJ MGP_WSBEiJ_G0025029
protein coding gene Chr2:60844929-60924742 (+)



Homology
more
  • Human Ortholog
    TANK, TRAF family member associated NFKB activator
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TANK, TRAF family member associated NFKB activator
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ITRAF, I-TRAF, TRAF2
  • Links
    NCBI Gene ID: 10010
    neXtProt AC: NX_Q92844
    UniProt: Q92844

  • Chr Location
    2q24.2; chr2:161136955-161236176 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 3081
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TANK
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice develop fatal glomerulonephritis owing to deposition of immune complexes. Dendritic cells, macrophages and B cells from these mice are hyper-responsive to stimuli leading to increased production of immunoglobulins and inflammatory cytokines.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000064289 Ensembl Gene Model | MGI Sequence Detail 75587 C57BL/6J ±  kb
    transcript ENSMUST00000078074 Ensembl | MGI Sequence Detail 2018 Not Applicable  
    polypeptide ENSMUSP00000077219 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 68
      cDNA 67
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36251, MGI:2139525, MGI:2443907
    References
    more
    • Summaries
      All 45
      Developmental Gene Expression 4
      Gene Ontology 9
      Phenotypes 9
    • Earliest
      J:34830 Rothe M, et al., I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8241-6
    • Latest
      J:246386 Bakshi S, et al., Identification of TBK1 complexes required for the phosphorylation of IRF3 and the production of interferon beta. Biochem J. 2017 Mar 15;474(7):1163-1174

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory