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Tank
Gene Detail
 Symbol
Name
ID
Tank
TRAF family member-associated Nf-kappa B activator
MGI:107676
Synonyms E430026L09Rik, I-TRAF
Feature Type protein coding gene
Genetic Map
Chromosome 2
35.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:61578585-61654171 bp, + strand
From VEGA annotation of GRCm38

  75587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3081  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tank

Human
homologs
Human Homolog TANK, TRAF family member-associated NFKB activator
NCBI Gene ID 10010
neXtProt AC  NX_Q92844
Human Synonyms  ITRAF, I-TRAF, TRAF2
Human Chr (Location)  2q24-q31; chr2:161136927-161236176 (+)  GRCh38
Alleles
and
phenotypes
All alleles(7) : Gene trapped(6) Targeted(1)
 
Homozygous null mice develop fatal glomerulonephritis owing to deposition of immune complexes. Dendritic cells, macrophages and B cells from these mice are hyper-responsive to stimuli leading to increased production of immunoglobulins and inflammatory cytokines.
 
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process I-kappaB kinase/NF-kappaB signaling
Component cytoplasm, intracellular
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (74)    Tissues (48)    Images (16)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 28
RT-PCR 46
cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(66) cDNA(65) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000013011 (Evidence)
Ensembl Gene ModelENSMUSG00000064289 (Evidence)
Entrez Gene21353 (Evidence)
UniGene244393
DFCITC1577852, TC1607969, TC1633476, TC1634938, TC1642696
DoTSDT.101137697, DT.101155263, DT.101180034, DT.101371169, DT.101735227, DT.103563702, DT.91370197, DT.97405402
NIA Mouse Gene IndexU001809
Consensus CDS ProjectCCDS16061.1, CCDS50592.1, CCDS50593.1
International Mouse Knockout Project StatusTank
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013011 VEGA Gene Model | MGI Sequence Detail 75587 C57BL/6J ±  kb
transcript OTTMUST00000031374 VEGA | MGI Sequence Detail 2016 Not Applicable 
polypeptide OTTMUSP00000014027 VEGA | MGI Sequence Detail 447 Not Applicable 

For the selected sequences
All sequences(85) RefSeq(14) UniProt(8)
Polymorphisms SNPs within 2kb(254 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024581 Tbk1/Ikki binding domain
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000003146 TRAF family member-associated NF-kappa-B activator
References (Earliest) J:34830 Rothe M, et al., I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction. Proc Natl Acad Sci U S A. 1996 Aug 6;93(16):8241-6
(Latest) J:194184 Salerno KM, et al., TRAF family member-associated NF-kappa B activator (TANK) expression increases in injured sensory neurons and is transcriptionally regulated by Sox11. Neuroscience. 2013 Feb 12;231:28-37
All references(42)
Other
accession IDs
MGD-MRK-36251, MGI:2139525, MGI:2443907

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory