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Gpm6b
Gene Detail
 Symbol
Name
ID
Gpm6b
glycoprotein m6b
MGI:107672
Synonyms Gpm6, M6B
Feature Type protein coding gene
Genetic Map
Chromosome X
76.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:166238911-166388988 bp, + strand
From VEGA annotation of GRCm38

  150078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128189  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Gpm6b

Human
homologs
Human Homolog GPM6B, glycoprotein M6B
NCBI Gene ID 2824
neXtProt AC  NX_Q13491
Human Synonyms  M6B
Human Chr (Location)  Xp22.2; chrX:13770943-13938732 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice null for this gene display axon-myelin interface irregularities but do not show motor function defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process extracellular matrix assembly, negative regulation of protein localization to cell surface, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (244)    Tissues (114)    Images (47)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 40
RNA in situ 201
RT-PCR 3
cDNA source data(132)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(136) cDNA(134) Primer pair(1) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000019536 (Evidence)
Ensembl Gene ModelENSMUSG00000031342 (Evidence)
Entrez Gene14758 (Evidence)
UniGene222320
DFCITC1580519, TC1589862, TC1591117, TC1601676, TC1603004, TC1604881, TC1610729, TC1645370
DoTSDT.101218932, DT.101403589, DT.101403591, DT.101403593, DT.111031180, DT.40136064, DT.50316703, DT.91601618, DT.91601619, DT.94288101, DT.94288112, DT.97402978, DT.99863943, DT.99863944
NIA Mouse Gene IndexU043807
Consensus CDS ProjectCCDS30526.1, CCDS53243.1, CCDS53244.1, CCDS53245.1, CCDS53246.1, CCDS53247.1
International Mouse Knockout Project StatusGpm6b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019536 VEGA Gene Model | MGI Sequence Detail 150078 C57BL/6J ±  kb
transcript OTTMUST00000046660 VEGA | MGI Sequence Detail 3203 Not Applicable 
polypeptide OTTMUSP00000021078 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(125) RefSeq(20) UniProt(6)
Polymorphisms SNPs within 2kb(659 from dbSNP Build 137)    SNPs within 2kb including multiple locations(661)
Protein-related
information
ResourceIDDescription
InterPro IPR001614 Myelin proteolipid protein PLP
InterPro IPR018237 Myelin proteolipid protein PLP, conserved site
Protein Ontology PR:000008179 neuronal membrane glycoprotein M6-b
References (Earliest) J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(46)
Other
accession IDs
MGD-MRK-33055, MGD-MRK-36247, MGI:2147902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory