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Gpm6b
Gene Detail
Symbol

Name
ID
Gpm6b
glycoprotein m6b
MGI:107672
Synonyms
Gpm6, M6B
Feature Type
protein coding gene
Genetic Map
Chromosome X
76.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:166238911-166388988 bp, + strand
From VEGA annotation of GRCm38

  150078 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128189  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Gpm6b

Human
homologs
Human Homolog GPM6B, glycoprotein M6B
NCBI Gene ID 2824
neXtProt AC  NX_Q13491
Human Synonyms  M6B
Human Chr (Location)  Xp22.2; chrX:13770943-13938732 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice null for this gene display axon-myelin interface irregularities but do not show motor function defects.
 
Interactions
Gpm6b interacts with 422 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process extracellular matrix assembly, negative regulation of protein localization to cell surface, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (244)    Tissues (114)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 40
RNA in situ 201
RT-PCR 3
cDNA source data(132)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(136) cDNA(134) Primer pair(1) Other(1)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019536 VEGA Gene Model | MGI Sequence Detail 150078 C57BL/6J ±  kb
transcript OTTMUST00000046660 VEGA | MGI Sequence Detail 3203 Not Applicable 
polypeptide OTTMUSP00000021078 VEGA | MGI Sequence Detail 328 Not Applicable 

For the selected sequences
All sequences(130) RefSeq(20) UniProt(11)
Polymorphisms
SNPs within 2kb(659 from dbSNP Build 137)    SNPs within 2kb including multiple locations(661)
Protein-related
information
ResourceIDDescription
InterPro IPR001614 Myelin proteolipid protein PLP
InterPro IPR018237 Myelin proteolipid protein PLP, conserved site
Protein Ontology PR:000008179 neuronal membrane glycoprotein M6-b
References
(Earliest) J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(46)
Other
accession IDs
MGD-MRK-33055, MGD-MRK-36247, MGI:2147902

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory