Gpm6a MGI Mouse Gene Detail - MGI:107671

Gpm6a Gene Detail

Symbol

Gpm6a
Name

glycoprotein m6a
Synonyms

Gpm6, M6A

Feature Type

protein coding gene
IDs

MGI:107671
NCBI Gene: 234267
Gene Overview

MyGene.info: GPM6A

Sequence Map

Chr8:54954843-55060871 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
Download
Sequence

106029 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 29.33 cM, cytoband B3.2
Mapping Data

2 experiments

Human Ortholog

GPM6A, glycoprotein M6A

Vertebrate Orthologs

10

Human Ortholog

GPM6A, glycoprotein M6A
Orthology source: HomoloGene, HGNC
Synonyms

GPM6, M6A
Links

HGNC:4460

NCBI Gene ID: 2823

neXtProt AC: NX_P51674

UniProt: P51674
Chr Location

4q34.2; chr4:175632937-176002691 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3864
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GPM6A
Protein SuperFamily

myelin proteolipid protein
Gene Tree

Gpm6a

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
8 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Chemically induced (other)

1
Targeted

3
Genomic Mutations

1 involving Gpm6a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

16 strains or lines available

Homozygous mutation of this gene results in increased percentage of total body fat and total body fat mass.

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All GO Annotations

19
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

155
Tissues

49
cDNA Data

132
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpm6a

ZFIN gpm6aa, gpm6ab

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Gpm6a interacts with 360 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

37
RefSeq

6
UniProt

3
CCDS

CCDS22310.1
UniGene

241700

			Length	Strain/Species	Flank
genomic	OTTMUSG00000060637	VEGA Gene Model \| MGI Sequence Detail	106029	C57BL/6J	± kb
transcript	OTTMUST00000148302	VEGA \| MGI Sequence Detail	3215	Not Applicable
polypeptide	OTTMUSP00000077107	VEGA \| MGI Sequence Detail	278	Not Applicable

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SNPs within 2kb

1419 from dbSNP Build 142

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UniProt

3 Sequences
Protein Ontology

PR:000008178 neuronal membrane glycoprotein M6-a

(term hierarchy)
InterPro Domains

IPR001614 Myelin proteolipid protein PLP

IPR018237 Myelin proteolipid protein PLP, conserved site

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All nucleic 132

cDNA 132

Microarray probesets 4

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MGD-MRK-33055, MGD-MRK-36246

Summaries

All 42

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 8
Earliest

J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
Latest

J:240680 Honda A, et al., Extracellular Signals Induce Glycoprotein M6a Clustering of Lipid Rafts and Associated Signaling Molecules. J Neurosci. 2017 Apr 12;37(15):4046-4064

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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