Gpm6a
Gene Detail

Symbol Name ID

Gpm6a glycoprotein m6a MGI:107671

Synonyms

Gpm6, M6A

Feature Type

protein coding gene

Genetic Map

Chromosome 8

29.33 cM, cytoband B3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:54954728-55060877 bp, + strand From Ensembl annotation of GRCm38   106150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:3864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Gpm6a

Human homologs

Human Homolog		GPM6A, glycoprotein M6A
NCBI Gene ID		2823
neXtProt AC		NX_P51674
Human Synonyms		GPM6, M6A
Human Chr (Location)		4q34; chr4:175632937-176002691 (-)  GRCh38

Mutations, alleles, and phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene results in increased percentage of total body fat and total body fat mass.

 

Interactions

Gpm6a interacts with 361 markers (Mir1a-1, Mir1a-2, Mir1b, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	calcium ion transmembrane transport, nervous system development, ...
Component	axonal growth cone, cell projection, ...
Function	calcium channel activity

External Resources: FuncBase

Expression

Literature Summary: (10 records)

Data Summary: Results (136)    Tissues (48)    Images (37)
Theiler Stages: 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	93

cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular reagents

All nucleic(132) cDNA(132)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031517 (Evidence)
Entrez Gene	234267 (Evidence)
UniGene	241700
DFCI	TC1571907, TC1659555, TC1757139
DoTS	DT.110871470, DT.110871510, DT.55244352, DT.87072513, DT.99864630
NIA Mouse Gene Index	U009342
Consensus CDS Project	CCDS22310.1
International Mouse Knockout Project Status	Gpm6a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031517	Ensembl Gene Model | MGI Sequence Detail	106150	C57BL/6J
transcript	ENSMUST00000033915	Ensembl | MGI Sequence Detail	3336	Not Applicable
polypeptide	ENSMUSP00000033915	Ensembl | MGI Sequence Detail	278	Not Applicable

All sequences(43) RefSeq(6) UniProt(3)

Polymorphisms

SNPs within 2kb(1428 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001614	Myelin proteolipid protein PLP
InterPro	IPR018237	Myelin proteolipid protein PLP, conserved site
Protein Ontology	PR:000008178	neuronal membrane glycoprotein M6-a

References

(Earliest) J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
(Latest) J:194339 Li Y, et al., Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2324-9
All references(44)

Other accession IDs

MGD-MRK-33055, MGD-MRK-36246