Gpm6a MGI Mouse Gene Detail - MGI:107671

Symbol

Gpm6a
Name

glycoprotein m6a
Synonyms

Gpm6, M6A

Feature Type

protein coding gene
IDs

MGI:107671
NCBI Gene: 234267
Alliance

gene page
Transcription Start Sites

19 TSS

Sequence Map

Chr8:55407878-55513906 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 8, 29.33 cM, cytoband B3.2
Mapping Data

2 experiments

SNPs within 2kb

2566 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107671	protein coding gene	Chr8:55232469-55513913 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0033615	protein coding gene	Chr8:54610898-54732385 (+)
A/J	MGP_AJ_G0033597	protein coding gene	Chr8:52319523-52427111 (+)
AKR/J	MGP_AKRJ_G0033522	protein coding gene	Chr8:53823692-53932805 (+)
BALB/cJ	MGP_BALBcJ_G0033594	protein coding gene	Chr8:52566371-52680689 (+)
C3H/HeJ	MGP_C3HHeJ_G0033303	protein coding gene	Chr8:54522645-54635654 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034110	protein coding gene	Chr8:56640592-56772687 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031058	protein coding gene	Chr8:48132867-48232038 (+)
CAST/EiJ	MGP_CASTEiJ_G0032629	protein coding gene	Chr8:54125788-54247043 (+)
CBA/J	MGP_CBAJ_G0033282	protein coding gene	Chr8:58718135-58843911 (+)
DBA/2J	MGP_DBA2J_G0033435	protein coding gene	Chr8:52130810-52237971 (+)
FVB/NJ	MGP_FVBNJ_G0033376	protein coding gene	Chr8:51474693-51582468 (+)
LP/J	MGP_LPJ_G0033523	protein coding gene	Chr8:54600796-54721780 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0033420	protein coding gene	Chr8:60043140-60240574 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034128	protein coding gene	Chr8:54088088-54200004 (+)
PWK/PhJ	MGP_PWKPhJ_G0032337	protein coding gene	Chr8:51655689-51767977 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032173	protein coding gene	Chr8:53191363-53309551 (+)
WSB/EiJ	MGP_WSBEiJ_G0032745	protein coding gene	Chr8:54348200-54472454 (+)

Human Ortholog

GPM6A, glycoprotein M6A

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

GPM6A, glycoprotein M6A
Synonyms

GPM6, M6A
Links

HGNC:4460

NCBI Gene ID: 2823

UniProt: P51674
Chr Location

4q34.2; chr4:175632934-176002664 (-) GRCh38

MGI Vertebrate Homology

Gpm6a stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: GPM6A
Gene Tree

Gpm6a

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Chemically induced (other)

1
Endonuclease-mediated

3
Targeted

3
Genomic Mutations

1 involving Gpm6a
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Homozygous mutation of this gene results in increased percentage of total body fat and total body fat mass.

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All GO Annotations

58
GO References

12

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

867
Tissues

50
cDNA Data

134
Literature Summary

16

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gpm6a

ZFIN gpm6aa, gpm6ab

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All Sequences

52
RefSeq

6
UniProt

3
CCDS

CCDS22310.1

Ensembl

ENSMUSG00000031517 (Evidence)
NCBI Gene

234267

			Length	Strain/Species	Flank
genomic	ENSMUSG00000031517	Ensembl Gene Model \| MGI Sequence Detail	106029	C57BL/6J	± kb
transcript	ENSMUST00000033915	Ensembl \| MGI Sequence Detail	3215	Not Applicable
polypeptide	ENSMUSP00000033915	Ensembl \| MGI Sequence Detail	278	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000008178 neuronal membrane glycoprotein M6-a

(term hierarchy)
InterPro Domains

IPR001614 Myelin proteolipid protein PLP

IPR018237 Myelin proteolipid protein PLP, conserved site
GlyGen

P35802 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)

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All nucleic 135

cDNA 134

Primer pair 1

Microarray probesets 4

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MGD-MRK-33055, MGD-MRK-36246

Summaries

All 57

Developmental Gene Expression 16

Gene Ontology 12

Phenotypes 11
Earliest

J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
Latest

J:365670 Chen W, et al., Zdhhc1- and Zdhhc2-mediated Gpm6a palmitoylation is essential for maintenance of mammary stem cell activity. Cell Rep. 2024 Sep 24;43(9):114762

TSS for Gpm6a:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr77379	Chr8:55407844-55407855 (+)	-28 bp
Tssr77380	Chr8:55407872-55407889 (+)	3 bp
Tssr77381	Chr8:55407891-55407907 (+)	21 bp
Tssr77382	Chr8:55407926-55407962 (+)	66 bp
Tssr77383	Chr8:55407969-55407984 (+)	99 bp
Tssr77384	Chr8:55408004-55408009 (+)	129 bp
Tssr77385	Chr8:55408029-55408045 (+)	159 bp
Tssr77386	Chr8:55408058-55408059 (+)	181 bp
Tssr77387	Chr8:55408061-55408072 (+)	189 bp
Tssr77388	Chr8:55408128-55408152 (+)	262 bp
Tssr77389	Chr8:55408175-55408218 (+)	319 bp
Tssr77390	Chr8:55408236-55408247 (+)	364 bp
Tssr77391	Chr8:55408248-55408266 (+)	379 bp
Tssr77392	Chr8:55408281-55408315 (+)	420 bp
Tssr77393	Chr8:55431928-55431940 (+)	24,056 bp
Tssr77394	Chr8:55438985-55438991 (+)	31,110 bp
Tssr77395	Chr8:55512144-55512159 (+)	104,274 bp
Tssr77396	Chr8:55512187-55512199 (+)	104,315 bp
Tssr2567	Chr8:55512257-55512276 (+)	104,389 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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