Gpm6a
Gene Detail

Symbol Name ID

Gpm6a glycoprotein m6a MGI:107671

Synonyms

Gpm6, M6A

Feature Type

protein coding gene

Genetic Map

Chromosome 8

29.33 cM, cytoband B3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr8:54954728-55060877 bp, + strand From Ensembl annotation of GRCm38   106150 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gpm6a ± 2 cM)

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Gpm6a

Human ortholog

GPM6A glycoprotein M6A NCBI Gene ID 2823
Human Synonyms: GPM6, M6A
Human Chr4:176554088-176923648 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene results in increased percentage of total body fat and total body fat mass.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	calcium ion transmembrane transport, nervous system development, ...
Component	axonal growth cone, cell projection, ...
Function	calcium channel activity

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (155)    Tissues (49)    Images (37)
Theiler Stages: 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	42
RNA in situ	113

cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(132) cDNA(132)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000031517 (Evidence)
Entrez Gene	234267 (Evidence)
UniGene	241700
DFCI	TC1571907, TC1659555, TC1757139
DoTS	DT.110871470, DT.110871510, DT.55244352, DT.87072513, DT.99864630
NIA Mouse Gene Index	U009342
Consensus CDS Project	CCDS22310.1
International Mouse Knockout Project Status	Gpm6a

Sequences

Length	Strain/Species
genomic	ENSMUSG00000031517	Ensembl Gene Model | MGI Sequence Detail	106150	C57BL/6J
transcript	ENSMUST00000033915	Ensembl | MGI Sequence Detail	3336	Not Applicable
polypeptide	ENSMUSP00000033915	Ensembl | MGI Sequence Detail	278	Not Applicable

All sequences(43) RefSeq(6) UniProt(3)

Polymorphisms

SNPs(511 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001614	Myelin proteolipid protein PLP
InterPro	IPR018237	Myelin proteolipid protein PLP, conserved site
Protein Ontology	PR:000008178	neuronal membrane glycoprotein M6-a

References

(Earliest) J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
(Latest) J:184737 Sato Y, et al., Induction of axon growth arrest without growth cone collapse through the N-terminal region of four-transmembrane glycoprotein M6a. Dev Neurobiol. 2011 Sep;71(9):733-46
All references(43)

Other accession IDs

MGD-MRK-33055, MGD-MRK-36246