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Gpm6a
Gene Detail
 Symbol
Name
ID
Gpm6a
glycoprotein m6a
MGI:107671
Synonyms Gpm6, M6A
Feature Type protein coding gene
Genetic Map
Chromosome 8
29.33 cM, cytoband B3.2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr8:54954728-55060877 bp, + strand
From Ensembl annotation of GRCm38

  106150 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3864  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: myelin proteolipid protein
Gene Tree: Gpm6a

Human
homologs
Human Homolog GPM6A, glycoprotein M6A
NCBI Gene ID 2823
neXtProt AC  NX_P51674
Human Synonyms  GPM6, M6A
Human Chr (Location)  4q34; chr4:175632937-176002691 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased percentage of total body fat and total body fat mass.
 
Interactions
Gpm6a interacts with 361 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process calcium ion transmembrane transport, nervous system development, ...
Component axonal growth cone, cell projection, ...
Function calcium channel activity
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (155)    Tissues (49)    Images (37)
Theiler Stages: 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 42
RNA in situ 113
cDNA source data(132)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(132) cDNA(132)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031517 (Evidence)
Entrez Gene234267 (Evidence)
UniGene241700
DFCITC1571907, TC1659555, TC1757139
DoTSDT.110871470, DT.110871510, DT.55244352, DT.87072513, DT.99864630
NIA Mouse Gene IndexU009342
Consensus CDS ProjectCCDS22310.1
International Mouse Knockout Project StatusGpm6a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031517 Ensembl Gene Model | MGI Sequence Detail 106150 C57BL/6J ±  kb
transcript ENSMUST00000033915 Ensembl | MGI Sequence Detail 3336 Not Applicable 
polypeptide ENSMUSP00000033915 Ensembl | MGI Sequence Detail 278 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(1428 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001614 Myelin proteolipid protein PLP
InterPro IPR018237 Myelin proteolipid protein PLP, conserved site
Protein Ontology PR:000008178 neuronal membrane glycoprotein M6-a
References (Earliest) J:26641 Baumrind NL, et al., EMA: a developmentally regulated cell-surface glycoprotein of CNS neurons that is concentrated at the leading edge of growth cones. Dev Dyn. 1992 Aug;194(4):311-25
(Latest) J:194339 Li Y, et al., Mesothelial cells give rise to hepatic stellate cells and myofibroblasts via mesothelial-mesenchymal transition in liver injury. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):2324-9
All references(44)
Other
accession IDs
MGD-MRK-33055, MGD-MRK-36246

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory