Scn9a
Gene Detail

Symbol Name ID

Scn9a sodium channel, voltage-gated, type IX, alpha MGI:107636

Synonyms

PN1

Feature Type

protein coding gene

Genetic Map

Chromosome 2

39.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:66480080-66634952 bp, - strand From VEGA annotation of GRCm38   154873 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2237  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: voltage-gated sodium channel
Gene Tree: Scn9a

Human homologs

Human Homolog		SCN9A, sodium channel, voltage-gated, type IX, alpha subunit
NCBI Gene ID		6335
neXtProt AC		NX_Q15858
Human Synonyms		ETHA, FEB3B, GEFSP7, Nav1.7, NENA, NE-NA, PN1, SFNP
Human Chr (Location)		2q24; chr2:167051695-167232497 (-)  GRCh37.p10
Disease Associations		(5) Diseases Associated with Human SCN9A

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Mice homozygous for a knock-out allele exhibit prenatal/neonatal lethality. Mice homozygous for a knock-in allele exhibit increased susceptibility to electrically induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (25 annotations)

Process	behavioral response to pain, inflammatory response, ...
Component	integral to membrane, membrane, ...
Function	ion channel activity, sodium channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (94)    Tissues (53)    Images (11)
Theiler Stages: 28

Assay Type	Results
In situ reporter (knock in)	56
RT-PCR	38

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(18) Genomic(1) cDNA(15) Primer pair(1) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000013103 (Evidence)
Ensembl Gene Model	ENSMUSG00000075316 (Evidence)
Entrez Gene	20274 (Evidence)
UniGene	440889
DFCI	TC1592176, TC1650272, TC1672541
DoTS	DT.40174597, DT.91295122, DT.91333438
NIA Mouse Gene Index	U222184
Consensus CDS Project	CCDS38132.1
International Mouse Knockout Project Status	Scn9a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013103	VEGA Gene Model | MGI Sequence Detail	154873	C57BL/6J
transcript	OTTMUST00000031622	VEGA | MGI Sequence Detail	9840	Not Applicable
polypeptide	OTTMUSP00000014089	VEGA | MGI Sequence Detail	1984	Not Applicable

All sequences(50) RefSeq(2) UniProt(9)

Polymorphisms

RFLP(4) : SNPs(846 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024583	Domain of unknown function DUF3451
InterPro	IPR005821	Ion transport domain
InterPro	IPR000048	IQ motif, EF-hand binding site
InterPro	IPR010526	Sodium ion transport-associated
InterPro	IPR001696	Voltage gated sodium channel, alpha subunit
Protein Ontology	PR:000002104	sodium channel type 9 subunit alpha

References

(Earliest) J:45865 D'Arcangelo G, et al., Neuronal growth factor regulation of two different sodium channel types through distinct signal transduction pathways. J Cell Biol. 1993 Aug;122(4):915-21
(Latest) J:186621 Shields SD, et al., Sodium channel nav1.7 is essential for lowering heat pain threshold after burn injury. J Neurosci. 2012 Aug 8;32(32):10819-32
All references(37)

Other accession IDs

MGD-MRK-36210