About   Help   FAQ
Larp7 Gene Detail
Summary
  • Symbol
    Larp7
  • Name
    La ribonucleoprotein domain family, member 7
  • Synonyms
    C330027G06Rik, D3Wsu161e
  • Feature Type
    protein coding gene
  • IDs
    MGI:107634
    NCBI Gene: 28036
Location & Maps
more
  • Sequence Map
    Chr3:127536714-127553349 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16636 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 56.54 cM, cytoband H1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    LARP7, La ribonucleoprotein domain family member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    LARP7, La ribonucleoprotein domain family member 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ALAZS, HDCMA18P, PIP7S
  • Links
    NCBI Gene ID: 51574
    neXtProt AC: NX_Q4G0J3

  • Chr Location
    4q25; chr4:112636964-112657592 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 88843
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: LARP7
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human LARP7 associations

Human Disease Mouse Models
       Alazami Syndrome; ALAZS   OMIM: 615071
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    34
  • Chemically induced (other)
    1
  • Gene trapped
    30
  • Radiation induced
    1
  • Targeted
    2
  • Genomic Mutations
    2 involving Larp7
  • Incidental Mutations
Mice homozygous for a null mutation display complete perinatal lethality and a decrease in primordial germ cell number and proliferation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052794 VEGA Gene Model | MGI Sequence Detail 16636 C57BL/6J ±  kb
transcript OTTMUST00000132145 VEGA | MGI Sequence Detail 2121 Not Applicable  
polypeptide OTTMUSP00000070501 VEGA | MGI Sequence Detail 570 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    158 from dbSNP Build 142
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000009673 La-related protein 7
  • InterPro Domains
    IPR014886 La protein, RNA-binding domain
    IPR002344 Lupus La protein
    IPR012677 Nucleotide-binding alpha-beta plait domain
    IPR006630 RNA-binding protein Lupus La
    IPR000504 RNA recognition motif domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 26
    cDNA 20
    Primer pair 4
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36208, MGI:1915530
References
more
  • Summaries
    All 39
    Developmental Gene Expression 9
    Gene Ontology 4
    Phenotypes 10
  • Earliest
    J:34518 Kerr SM, et al., Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996 Aug;5(8):1139-48
  • Latest
    J:228522 Yang SL, et al., MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation. Dev Biol. 2015 Dec 1;408(1):140-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/17/2016
MGI 6.05
The Jackson Laboratory