About   Help   FAQ
Larp7
Gene Detail
Symbol

Name
ID
Larp7
La ribonucleoprotein domain family, member 7
MGI:107634
Synonyms
C330027G06Rik, D3Wsu161e
Feature Type
protein coding gene
Genetic Map
Chromosome 3
56.54 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr3:127536954-127553348 bp, - strand
From Ensembl annotation of GRCm38

  16395 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:88843  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Larp7

Human
homologs
Human Homolog LARP7, La ribonucleoprotein domain family, member 7
NCBI Gene ID 51574
neXtProt AC  NX_Q4G0J3
Human Synonyms  ALAZS, PIP7S
Human Chr (Location)  4q25; chr4:112636964-112657592 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human LARP7
Mutations,
alleles, and
phenotypes
All mutations/alleles(31) : Gene trapped(29) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null mutation display complete perinatal lethality and a decrease in primordial germ cell number and proliferation.
 
Interactions
Larp7 interacts with 3 markers (Mir212, Mir495, Mir1191)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process germ cell proliferation, negative regulation of chromatin binding, ...
Component cytoplasm, Golgi apparatus, ...
Function nucleic acid binding, nucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (38)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
RT-PCR 21
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(20) Primer pair(4) Other(2)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000027968 (Evidence)
Entrez Gene28036 (Evidence)
DoTSDT.101136677, DT.101269850, DT.490557, DT.94121620
NIA Mouse Gene IndexU024624, U091160
Consensus CDS ProjectCCDS38626.1
International Mouse Knockout Project StatusLarp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027968 Ensembl Gene Model | MGI Sequence Detail 16395 C57BL/6J ±  kb
transcript ENSMUST00000029588 Ensembl | MGI Sequence Detail 1880 Not Applicable 
polypeptide ENSMUSP00000029588 Ensembl | MGI Sequence Detail 570 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(158 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002344 Lupus La protein
InterPro IPR012677 Nucleotide-binding, alpha-beta plait
InterPro IPR014886 RNA-binding motif
InterPro IPR006630 RNA-binding protein Lupus La
InterPro IPR000504 RNA recognition motif domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000009673 La-related protein 7
References
(Earliest) J:34518 Kerr SM, et al., Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996 Aug;5(8):1139-48
(Latest) J:191206 Okamura D, et al., Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15;26(22):2477-82
All references(39)
Other
accession IDs
MGD-MRK-36208, MGI:1915530

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory