Larp7
Gene Detail

Symbol Name ID

Larp7 La ribonucleoprotein domain family, member 7 MGI:107634

Synonyms

C330027G06Rik, D3Wsu161e

Feature Type

protein coding gene

Genetic Map

Chromosome 3

56.54 cM, cytoband H1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr3:127536954-127553348 bp, - strand From Ensembl annotation of GRCm38   16395 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Larp7 ± 2 cM)

Gene Tree: Larp7

Human ortholog

LARP7 La ribonucleoprotein domain family, member 7 NCBI Gene ID 51574
Human Synonyms: ALAZS, PIP7S
Human Chr4:113558120-113578742 bp, + strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human LARP7 (1)

Alleles and phenotypes

All alleles(31) : Targeted(2) Gene trapped(29)
 

Mice homozygous for a null mutation display complete perinatal lethality and a decrease in primordial germ cell number and proliferation.

 

Gene Ontology (GO) classifications

All GO classifications: (12 annotations)

Process	germ cell proliferation, negative regulation of chromatin binding, ...
Component	nucleus, ribonucleoprotein complex
Function	nucleic acid binding, nucleotide binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (65)    Tissues (37)    Images (8)
Theiler Stages: 11, 13, 17, 21, 23, 26, 28

Assay Type	Results
RNA in situ	44
RT-PCR	21

cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(20) Primer pair(4) Other(2)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000027968 (Evidence)
Entrez Gene	28036 (Evidence)
DoTS	DT.101136677, DT.101269850, DT.490557, DT.94121620
NIA Mouse Gene Index	U024624, U091160
Consensus CDS Project	CCDS38626.1
International Mouse Knockout Project Status	Larp7

Sequences

Length	Strain/Species
genomic	ENSMUSG00000027968	Ensembl Gene Model | MGI Sequence Detail	16395	C57BL/6J
transcript	ENSMUST00000029588	Ensembl | MGI Sequence Detail	1880	Not Applicable
polypeptide	ENSMUSP00000029588	Ensembl | MGI Sequence Detail	570	Not Applicable

All sequences(37) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(104 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002344	Lupus La protein
InterPro	IPR012677	Nucleotide-binding, alpha-beta plait
InterPro	IPR014886	RNA-binding motif
InterPro	IPR006630	RNA-binding protein Lupus La
InterPro	IPR000504	RNA recognition motif domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000009673	La-related protein 7

References

(Earliest) J:34518 Kerr SM, et al., Ott, a mouse X-linked multigene family expressed specifically during meiosis. Hum Mol Genet. 1996 Aug;5(8):1139-48
(Latest) J:191206 Okamura D, et al., Cell cycle gene-specific control of transcription has a critical role in proliferation of primordial germ cells. Genes Dev. 2012 Nov 15;26(22):2477-82
All references(39)

Other accession IDs

MGD-MRK-36208, MGI:1915530