About   Help   FAQ
Lxn
Gene Detail
Symbol

Name
ID
Lxn
latexin
MGI:107633
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:67457998-67463926 bp, - strand
From VEGA annotation of GRCm38

  5929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: LXN
Protein SuperFamily: retinoic acid receptor responder protein 1/ carboxypeptidase inhibitor, latexin/ovocalyxin-32 types
Gene Tree: Lxn

Human
homologs
LXN, latexin
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 56925
neXtProt AC: NX_Q9BS40

Human Synonyms: ECI, TCI

Human Chr (Location): 3q25.32; chr3:158666414-158672693 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor.
 
Interactions
Lxn interacts with 27 markers (Mir26a-1, Mir30b, Mir196a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (99)    Tissues (16)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 96
cDNA source data(81)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase lxn ; ZFIN lxn    NEW 
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029073 (Evidence)
Ensembl Gene Model ENSMUSG00000047557 (Evidence)
Entrez Gene 17035 (Evidence)
UniGene 2632
DFCI TC1576033
DoTS DT.99843679
NIA Mouse Gene Index U024128
PDB 1WNH
Consensus CDS Project CCDS17397.1
International Mouse Phenotyping Consortium Status Lxn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029073 VEGA Gene Model | MGI Sequence Detail 5929 C57BL/6J ±  kb
transcript OTTMUST00000072122 VEGA | MGI Sequence Detail 1112 Not Applicable 
polypeptide OTTMUSP00000037051 VEGA | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009684 Proteinase inhibitor I47, latexin
Protein Ontology PR:000009987 latexin
References
(Earliest) J:37801 Jin M, et al., Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner. Genomics. 1997 Feb 1;39(3):419-21
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(42)
Other
accession IDs
MGD-MRK-36207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory