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Lxn
Gene Detail
Symbol

Name
ID
Lxn
latexin
MGI:107633
Feature Type
protein coding gene
Genetic Map
Chromosome 3
30.98 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr3:67457998-67463926 bp, - strand
From VEGA annotation of GRCm38

  5929 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36361  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: retinoic acid receptor responder protein 1/ carboxypeptidase inhibitor, latexin/ovocalyxin-32 types
Gene Tree: Lxn

Human
homologs
Human Homolog LXN, latexin
NCBI Gene ID 56925
neXtProt AC  NX_Q9BS40
Human Synonyms  ECI, TCI
Human Chr (Location)  3q25.32; chr3:158666414-158672693 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted null mutation display reduced sensitivity to acute thermal pain, which can be reversed by exogenous carboxypeptidase inhibitor.
 
Interactions
Lxn interacts with 28 markers (Mir26a-1, Mir30b, Mir196a-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (99)    Tissues (16)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 96
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(83) Genomic(1) cDNA(82)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029073 (Evidence)
Ensembl Gene ModelENSMUSG00000047557 (Evidence)
Entrez Gene17035 (Evidence)
UniGene2632
DFCITC1576033
DoTSDT.99843679
NIA Mouse Gene IndexU024128
PDB1WNH
Consensus CDS ProjectCCDS17397.1
International Mouse Knockout Project StatusLxn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029073 VEGA Gene Model | MGI Sequence Detail 5929 C57BL/6J ±  kb
transcript OTTMUST00000072122 VEGA | MGI Sequence Detail 1112 Not Applicable 
polypeptide OTTMUSP00000037051 VEGA | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(86 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR009684 Proteinase inhibitor I47, latexin
Protein Ontology PR:000009987 latexin
References
(Earliest) J:37801 Jin M, et al., Mapping to mouse chromosome 3 of the gene encoding latexin (Lxn) expressed in neocortical neurons in a region-specific manner. Genomics. 1997 Feb 1;39(3):419-21
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(44)
Other
accession IDs
MGD-MRK-36207

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory