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Prdm2 Gene Detail
Summary
  • Symbol
    Prdm2
  • Name
    PR domain containing 2, with ZNF domain
  • Synonyms
    4833427P12Rik, E330024L24Rik, KMT8, LOC381568, Riz, Riz1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107628
    NCBI Gene: 110593
  • Gene Overview
    MyGene.info: PRDM2
Location & Maps
more
  • Sequence Map
    Chr4:143107391-143212995 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      105605 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 76.84 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PRDM2, PR/SET domain 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRDM2, PR/SET domain 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HUMHOXY1, KMT8, KMT8A, MTB-ZF, RIZ, RIZ1, RIZ2
  • Links
    NCBI Gene ID: 7799
    neXtProt AC: NX_Q13029

  • Chr Location
    1p36.21; chr1:13700240-13825079 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    2 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Chemically induced (other)
    1
  • Gene trapped
    33
  • Targeted
    2
  • Genomic Mutations
    2 involving Prdm2
  • Incidental Mutations
Homozygous null mice have shortened life spans, becoming moribund due to increased incidence of tumors. Mice had a broad spectrum of unusual tumors in multiple organs, with a high incidence of diffuse large B cell lymphomas.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010119 VEGA Gene Model | MGI Sequence Detail 105605 C57BL/6J ±  kb
transcript OTTMUST00000023519 VEGA | MGI Sequence Detail 7304 Not Applicable  
polypeptide OTTMUSP00000010741 VEGA | MGI Sequence Detail 1709 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1063 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • InterPro Domains
    IPR009170 Predicted retinoblastoma binding protein (RIZ)
    IPR001214 SET domain
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 16
    cDNA 16

    Microarray probesets 6
Other
Accession IDs
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MGD-MRK-36202, MGI:1921838, MGI:2685879
References
more
  • Summaries
    All 37
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:40271 Buyse IM, et al., The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope with the adenovirus E1A protein. Proc Natl Acad Sci U S A. 1995 May 9;92(10):4467-71
  • Latest
    J:194983 Ideno H, et al., Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development. Gene Expr Patterns. 2013 Mar-Apr;13(3-4):84-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory