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Il11 Gene Detail
Summary
  • Symbol
    Il11
  • Name
    interleukin 11
  • Synonyms
    IL-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:107613
    NCBI Gene: 16156
  • Gene Overview
    MyGene.info: IL11
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:4772378-4782857 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 2.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    43 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107613
protein coding gene Chr7:4772373-4782857 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031560
protein coding gene Chr7:1711630-1722124 (-)
A/J MGP_AJ_G0031534
protein coding gene Chr7:1711817-1723502 (-)
AKR/J MGP_AKRJ_G0031463
protein coding gene Chr7:1775538-1787118 (-)
BALB/cJ MGP_BALBcJ_G0031542
protein coding gene Chr7:1752662-1763459 (-)
C3H/HeJ MGP_C3HHeJ_G0031263
protein coding gene Chr7:1751486-1765242 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032003
protein coding gene Chr7:1776208-1786664 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029127
protein coding gene Chr7:1453740-1463914 (-)
CAST/EiJ MGP_CASTEiJ_G0030627
protein coding gene Chr7:1696463-1708127 (-)
CBA/J MGP_CBAJ_G0031221
protein coding gene Chr7:1966946-1979255 (-)
DBA/2J MGP_DBA2J_G0031380
protein coding gene Chr7:1686779-1697620 (-)
FVB/NJ MGP_FVBNJ_G0031332
protein coding gene Chr7:1653913-1664965 (-)
LP/J MGP_LPJ_G0031465
protein coding gene Chr7:1814157-1824517 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031371
protein coding gene Chr7:1908091-1918746 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032033
protein coding gene Chr7:1696179-1706631 (-)
PWK/PhJ MGP_PWKPhJ_G0030355
protein coding gene Chr7:1860474-1871071 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030180
protein coding gene Chr7:1737759-1749550 (-)
WSB/EiJ MGP_WSBEiJ_G0030722
protein coding gene Chr7:1707625-1717949 (-)



Homology
more
  • Human Ortholog
    IL11, interleukin 11
  • Vertebrate Orthologs
    5
  • Human Ortholog
    IL11, interleukin 11
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AGIF, IL-11
  • Links
    NCBI Gene ID: 3589
    neXtProt AC: NX_P20809
    UniProt: P20809

  • Chr Location
    19q13.42; chr19:55364382-55370463 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    11 phenotype references
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 16156 NCBI Gene Model | MGI Sequence Detail 10480 C57BL/6J ±  kb
transcript NM_008350 RefSeq | MGI Sequence Detail 1949 Not Specified  
polypeptide P47873 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 16
    cDNA 14
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36187
References
more
  • Summaries
    All 74
    Developmental Gene Expression 8
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:38817 Paul SR, et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7512-6
  • Latest
    J:250268 Schafer S, et al., IL-11 is a crucial determinant of cardiovascular fibrosis. Nature. 2017 Dec 7;552(7683):110-115

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory