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Il11 Gene Detail
Summary
  • Symbol
    Il11
  • Name
    interleukin 11
  • Synonyms
    IL-11
  • Feature Type
    protein coding gene
  • IDs
    MGI:107613
    NCBI Gene: 16156
  • Gene Overview
    MyGene.info: IL11
Location & Maps
more
  • Genetic Map
    Chromosome 7, 2.76 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
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  • Human Ortholog
    IL11, interleukin 11
  • Vertebrate Orthologs
    5
  • Human Ortholog
    IL11, interleukin 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AGIF, IL-11
  • Links
    NCBI Gene ID: 3589
    neXtProt AC: NX_P20809

  • Chr Location
    19q13.3-q13.4; chr19:55364382-55370463 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from multigenic genotypes
    10 phenotype references
  • All Mutations and Alleles
    5
  • Gene trapped
    1
  • Targeted
    2
  • Transgenic
    2
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000040054 VEGA Gene Model | MGI Sequence Detail 10485 C57BL/6J ±  kb
transcript OTTMUST00000104003 VEGA | MGI Sequence Detail 1949 Not Applicable  
polypeptide OTTMUSP00000058155 VEGA | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    43 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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Molecular
Reagents
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  • All nucleic 15
    cDNA 13
    Primer pair 1
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36187
References
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  • Summaries
    All 55
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 10
  • Earliest
    J:38817 Paul SR, et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7512-6
  • Latest
    J:186161 Hu B, et al., Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling. Cell. 2012 Jun 8;149(6):1207-20

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory