Il11 MGI Mouse Gene Detail - MGI:107613

Symbol

Il11
Name

interleukin 11
Synonyms

IL-11

Feature Type

protein coding gene
IDs

MGI:107613
NCBI Gene: 16156
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr7:4775372-4785858 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 7, 2.76 cM
Mapping Data

3 experiments

SNPs within 2kb

236 from dbSNP Build 142
Strain Annotations

19
PCR

1
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_107613	protein coding gene	Chr7:4775372-4785877 (-)
129S1/SvImJ	ENSMUSG00200040103	protein coding gene	Chr7:1502145-1512651 (-)
A/J	ENSMUSG00195051836	protein coding gene	Chr7:1484370-1494978 (-)
AKR/J	ENSMUSG00220024066	protein coding gene	Chr7:2600286-2610893 (+)
BALB/cJ	ENSMUSG00180042211	protein coding gene	Chr7:1448151-1458659 (-)
C3H/HeJ	ENSMUSG00175046908	protein coding gene	Chr7:1447247-1457855 (-)
C57BL/6NJ	ENSMUSG00215040122	protein coding gene	Chr7:1495369-1505857 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0029127	protein coding gene	Chr7:1453740-1463914 (-)
CAST/EiJ	ENSTCUG00005027317	protein coding gene	Chr7:1661951-1672662 (-)
CBA/J	ENSMUSG00210033910	protein coding gene	Chr7:1445709-1456317 (-)
DBA/2J	ENSMUSG00185039640	protein coding gene	Chr7:1628141-1638750 (-)
FVB/NJ	ENSMUSG00205019939	protein coding gene	Chr7:1426281-1436889 (-)
JF1/MsJ	ENSUMUG00000020792	protein coding gene	Chr7:1705714-1716195 (-)
LP/J	ENSMUSG00230037246	protein coding gene	Chr7:4647619-4658124 (-)
NOD/ShiLtJ	ENSMUSG00190044575	protein coding gene	Chr7:1518155-1528762 (-)
NZO/HlLtJ	ENSMUSG00225017055	protein coding gene	Chr7:2562573-2573056 (-)
PWK/PhJ	ENSLUMG00010041463	protein coding gene	Chr7:5218472-5228960 (-)
SPRET/EiJ	ENSMSPG00010036831	protein coding gene	Chr7:1624370-1635171 (-)
WSB/EiJ	ENSIUOG00005050781	protein coding gene	Chr7:1456155-1466655 (-)

Human Ortholog

IL11, interleukin 11

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

IL11, interleukin 11
Synonyms

AGIF, IL-11
Links

HGNC:5966

NCBI Gene ID: 3589

UniProt: P20809
Chr Location

19q13.42; chr19:55364382-55370463 (-) GRCh38

MGI Vertebrate Homology

Il11 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: IL11
Gene Tree

Il11

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Phenotype Summary

27 phenotypes from 3 alleles in 2 genetic backgrounds
24 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

26
Endonuclease-mediated

17
Gene trapped

1
Targeted

8
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

24 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null females are infertile and show reduced bone mass, suppressed bone formation response to mechanical loading, increased systemic adiposity, glucose intolerance and insulin resistance.

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All GO Annotations

32
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

612
Tissues

11
cDNA Data

13
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase il11

ZFIN il11a, il11b

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All Sequences

50
RefSeq

14
UniProt

4
CCDS

CCDS39740.1, CCDS71881.1

Ensembl

ENSMUSG00000004371 (Evidence)
NCBI Gene

16156

			Length	Strain/Species	Flank
genomic	ENSMUSG00000004371	Ensembl Gene Model \| MGI Sequence Detail	10487	C57BL/6J	± kb
transcript	ENSMUST00000094892	Ensembl \| MGI Sequence Detail	1949	Not Applicable
polypeptide	ENSMUSP00000092492	Ensembl \| MGI Sequence Detail	199	Not Applicable

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UniProt

4 Sequences
Protein Ontology

PR:000001366 interleukin-11

(term hierarchy)
InterPro Domains

IPR009079 Four-helical cytokine-like, core

IPR020438 Interleukin-11

IPR020412 Interleukin-11, mammalian

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All nucleic 19

cDNA 14

Primer pair 4

Other 1

Microarray probesets 3

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MGD-MRK-36187

Summaries

All 108

Developmental Gene Expression 12

Gene Ontology 10

Phenotypes 24
Earliest

J:38817 Paul SR, et al., Molecular cloning of a cDNA encoding interleukin 11, a stromal cell-derived lymphopoietic and hematopoietic cytokine. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7512-6
Latest

J:390405 Harumiya S, et al., A4gnt-deficient mice show enhanced IL-11Ralpha-gp130-JAK2-STAT3 signaling in early stages of gastric tumorigenesis: Comparative analysis with A4gnt and Il11 doubly-deficient mice. Am J Pathol. 2026 Jul 28;

TSS for Il11:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr70542	Chr7:4786843-4786852 (-)	-990 bp
Tssr70541	Chr7:4781140-4781143 (-)	4,716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24