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Rtn2
Gene Detail
Symbol

Name
ID
Rtn2
reticulon 2 (Z-band associated protein)
MGI:107612
Synonyms
Nspl1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19282662-19296164 bp, + strand
From Ensembl annotation of GRCm38

  13503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Rtn2

Human
homologs
Human Homolog RTN2, reticulon 2
NCBI Gene ID 6253
neXtProt AC  NX_O75298
Human Synonyms  NSP2, NSPL1, NSPLI, SPG12
Human Chr (Location)  19q13.32; chr19:45485288-45497055 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RTN2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous and homozygous for an allele disrupting the skeletal isoform exhibit abollished or severely impaired glucose uptake in skeletal muscle.
 
Interactions
Rtn2 interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process intracellular protein transmembrane transport, regulation of glucose import
Component cell, endoplasmic reticulum, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (258)    Tissues (239)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 224
Northern blot 28
RT-PCR 6
cDNA source data(56)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(2) cDNA(58) Primer pair(5)
Microarray probesets(2)
Other database
links
Ensembl Gene ModelENSMUSG00000030401 (Evidence)
Entrez Gene20167 (Evidence)
UniGene24142
DFCITC1580473, TC1651327
DoTSDT.101373934, DT.533488, DT.97379876, DT.55157607
NIA Mouse Gene IndexU007760
Consensus CDS ProjectCCDS20896.1, CCDS39797.1
International Mouse Knockout Project StatusRtn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030401 Ensembl Gene Model | MGI Sequence Detail 13503 C57BL/6J ±  kb
transcript ENSMUST00000032559 Ensembl | MGI Sequence Detail 1956 Not Applicable 
polypeptide ENSMUSP00000032559 Ensembl | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(4) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003388 Reticulon
Protein Ontology PR:000014346 reticulon-2
References
(Earliest) J:2957 Lazo PS, et al., Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992 Jan 25;20(2):343-50
(Latest) J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
All references(35)
Other
accession IDs
MGD-MRK-36186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory