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Rtn2
Gene Detail
Symbol

Name
ID
Rtn2
reticulon 2 (Z-band associated protein)
MGI:107612
Synonyms
Nspl1
Feature Type
protein coding gene
Genetic Map
Chromosome 7
9.54 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:19282662-19296164 bp, + strand
From Ensembl annotation of GRCm38

  13503 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32180  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: RTN2
Gene Tree: Rtn2

Human
homologs
RTN2, reticulon 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6253
neXtProt AC: NX_O75298

Human Synonyms: NSP2, NSPL1, NSPLI, SPG12

Human Chr (Location): 19q13.32; chr19:45485288-45497055 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RTN2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(5) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice heterozygous and homozygous for an allele disrupting the skeletal isoform exhibit abollished or severely impaired glucose uptake in skeletal muscle.
 
Interactions
Rtn2 interacts with 119 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process intracellular protein transmembrane transport, regulation of glucose import
Component cell, endomembrane system, ...
Function molecular_function
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (258)    Tissues (238)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 224
Northern blot 28
RT-PCR 6
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rtn2 ; ZFIN rtn2a, rtn2b    NEW 
Molecular
reagents
All nucleic(65) Genomic(2) cDNA(58) Primer pair(5)
Microarray probesets(2)
Other database
links
Ensembl Gene Model ENSMUSG00000030401 (Evidence)
Entrez Gene 20167 (Evidence)
UniGene 24142
DFCI TC1651327, TC1580473
DoTS DT.55157607, DT.533488, DT.101373934, DT.97379876
NIA Mouse Gene Index U007760
Consensus CDS Project CCDS20896.1, CCDS39797.1
International Mouse Phenotyping Consortium Status Rtn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030401 Ensembl Gene Model | MGI Sequence Detail 13503 C57BL/6J ±  kb
transcript ENSMUST00000032559 Ensembl | MGI Sequence Detail 1956 Not Applicable 
polypeptide ENSMUSP00000032559 Ensembl | MGI Sequence Detail 471 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(4) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(99 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003388 Reticulon
Protein Ontology PR:000014346 reticulon-2
References
(Earliest) J:2957 Lazo PS, et al., Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992 Jan 25;20(2):343-50
(Latest) J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci. 2012;6:130
All references(35)
Other
accession IDs
MGD-MRK-36186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory