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Rtn2 Gene Detail
Summary
  • Symbol
    Rtn2
  • Name
    reticulon 2 (Z-band associated protein)
  • Synonyms
    Nspl1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107612
    NCBI Gene: 20167
  • Gene Overview
    MyGene.info: RTN2
Location & Maps
more
  • Sequence Map
    Chr7:19282624-19296160 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      13537 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    RTN2, reticulon 2
  • Vertebrate Orthologs
    6
  • Human Ortholog
    RTN2, reticulon 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    NSP2, NSPL1, NSPLI, SPG12
  • Links
    NCBI Gene ID: 6253
    neXtProt AC: NX_O75298

  • Chr Location
    19q13.32; chr19:45485288-45497055 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human RTN2 associations

Human Disease Mouse Models
       Spastic Paraplegia 12, Autosomal Dominant; SPG12   OMIM: 604805
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    3 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    5
  • Targeted
    1
  • Incidental Mutations
Mice heterozygous and homozygous for an allele disrupting the skeletal isoform exhibit abollished or severely impaired glucose uptake in skeletal muscle.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000058967 VEGA Gene Model | MGI Sequence Detail 13537 C57BL/6J ±  kb
transcript OTTMUST00000144676 VEGA | MGI Sequence Detail 1990 Not Applicable  
polypeptide OTTMUSP00000075382 VEGA | MGI Sequence Detail 471 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    99 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 65
    Genomic 2
    cDNA 58
    Primer pair 5

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-36186
References
more
  • Summaries
    All 32
    Developmental Gene Expression 7
    Gene Ontology 3
    Phenotypes 3
  • Earliest
    J:2957 Lazo PS, et al., Structure and mapping of the fosB gene. FosB downregulates the activity of the fosB promoter. Nucleic Acids Res. 1992 Jan 25;20(2):343-50
  • Latest
    J:190636 Wiese CB, et al., A genome-wide screen to identify transcription factors expressed in pelvic Ganglia of the lower urinary tract. Front Neurosci. 2012;6:130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/19/2016
MGI 6.03
The Jackson Laboratory