About   Help   FAQ
Npat Gene Detail
Summary
  • Symbol
    Npat
  • Name
    nuclear protein in the AT region
  • Feature Type
    protein coding gene
  • IDs
    MGI:107605
    NCBI Gene: 244879
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:53448347-53485642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 9, 29.12 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107605
protein coding gene Chr9:53448347-53486867 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034812
protein coding gene Chr9:52561471-52600290 (+)
A/J MGP_AJ_G0034793
protein coding gene Chr9:50909689-50947815 (+)
AKR/J MGP_AKRJ_G0034721
protein coding gene Chr9:52007919-52048682 (+)
BALB/cJ MGP_BALBcJ_G0034785
protein coding gene Chr9:50658613-50696411 (+)
C3H/HeJ MGP_C3HHeJ_G0034495
protein coding gene Chr9:52493616-52531266 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035304
protein coding gene Chr9:54044071-54083341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032217
protein coding gene Chr9:50320607-50357474 (+)
CAST/EiJ MGP_CASTEiJ_G0033817
protein coding gene Chr9:52489405-52532719 (+)
CBA/J MGP_CBAJ_G0034466
protein coding gene Chr9:55874292-55917952 (+)
DBA/2J MGP_DBA2J_G0034625
protein coding gene Chr9:50789230-50826468 (+)
FVB/NJ MGP_FVBNJ_G0034567
protein coding gene Chr9:49969382-50006850 (+)
LP/J MGP_LPJ_G0034707
protein coding gene Chr9:52867102-52905451 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034610
protein coding gene Chr9:57460664-57507837 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035326
protein coding gene Chr9:52016904-52055967 (+)
PWK/PhJ MGP_PWKPhJ_G0033521
protein coding gene Chr9:50765804-50804664 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033357
protein coding gene Chr9:52308956-52352634 (+)
WSB/EiJ MGP_WSBEiJ_G0033929
protein coding gene Chr9:52013311-52051438 (+)



Homology
more
  • Human Ortholog
    NPAT, nuclear protein, coactivator of histone transcription
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NPAT, nuclear protein, coactivator of histone transcription
  • Synonyms
    E14, E14/NPAT, p220
  • Links
    NCBI Gene ID: 4863
    neXtProt AC: NX_Q14207
    UniProt: Q14207

  • Chr Location
    11q22.3; chr11:108157215-108222638 (-)  GRCh38

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    32 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos fail to proceed from the morula to blastocyst stage and have an uncompacted appearance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000033054 Ensembl Gene Model | MGI Sequence Detail 37296 C57BL/6J ±  kb
    transcript ENSMUST00000035850 Ensembl | MGI Sequence Detail 6062 Not Applicable  
    polypeptide ENSMUSP00000048709 Ensembl | MGI Sequence Detail 1420 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36179, MGI:2143040, MGI:2143360
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 15
    • Earliest
      J:33856 Matsuda Y, et al., Comparative genome mapping of the ataxia-telangiectasia region in mouse, rat, and Syrian hamster. Genomics. 1996 Jun 15;34(3):347-52
    • Latest
      J:313720 Chen C, et al., The genetic association of the transcription factor NPAT with glycemic response to metformin involves regulation of fuel selection. PLoS One. 2021;16(7):e0253533

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.
    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory