About   Help   FAQ
Hmgcs1 Gene Detail
Summary
  • Symbol
    Hmgcs1
  • Name
    3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1
  • Synonyms
    B130032C06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:107592
    NCBI Gene: 208715
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:119690379-119708260 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, Syntenic
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    184 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107592
protein coding gene Chr13:119690351-119708260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020976
protein coding gene Chr13:122630053-122648253 (+)
A/J MGP_AJ_G0020926
protein coding gene Chr13:117758198-117778506 (+)
AKR/J MGP_AKRJ_G0020901
protein coding gene Chr13:121219079-121236715 (+)
BALB/cJ MGP_BALBcJ_G0020926
protein coding gene Chr13:118324618-118342206 (+)
C3H/HeJ MGP_C3HHeJ_G0020714
protein coding gene Chr13:121076810-121094262 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021362
protein coding gene Chr13:126315234-126333479 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018931
protein coding gene Chr13:112596260-112614488 (+)
CAST/EiJ MGP_CASTEiJ_G0020235
protein coding gene Chr13:120825601-120844625 (+)
CBA/J MGP_CBAJ_G0020677
protein coding gene Chr13:131059453-131076929 (+)
DBA/2J MGP_DBA2J_G0020800
protein coding gene Chr13:117238386-117255794 (+)
FVB/NJ MGP_FVBNJ_G0020784
protein coding gene Chr13:115848205-115865882 (+)
LP/J MGP_LPJ_G0020877
protein coding gene Chr13:122701869-122722476 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020810
protein coding gene Chr13:131857677-131876133 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021397
protein coding gene Chr13:120841257-120858701 (+)
PWK/PhJ MGP_PWKPhJ_G0019987
protein coding gene Chr13:116121365-116139012 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019809
protein coding gene Chr13:116985433-117003577 (+)
WSB/EiJ MGP_WSBEiJ_G0020293
protein coding gene Chr13:121443558-121461174 (+)



Homology
more
  • Human Ortholog
    HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HMGCS1, 3-hydroxy-3-methylglutaryl-CoA synthase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HMGCS
  • Links
    NCBI Gene ID: 3157
    neXtProt AC: NX_Q01581
    UniProt: Q01581

  • Chr Location
    5p12; chr5:43287470-43313512 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000093930 Ensembl Gene Model | MGI Sequence Detail 17882 C57BL/6J ±  kb
transcript ENSMUST00000179869 Ensembl | MGI Sequence Detail 3245 Not Applicable  
polypeptide ENSMUSP00000136944 Ensembl | MGI Sequence Detail 520 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000008637 hydroxymethylglutaryl-CoA synthase, cytoplasmic
  • EC
  • InterPro Domains
    IPR010122 Hydroxymethylglutaryl-CoA synthase, eukaryotic
    IPR000590 Hydroxymethylglutaryl-coenzyme A synthase, active site
    IPR013746 Hydroxymethylglutaryl-coenzyme A synthase C-terminal domain
    IPR013528 Hydroxymethylglutaryl-coenzyme A synthase, N-terminal
    IPR016039 Thiolase-like
Molecular
Reagents
less
  • All nucleic 401
    cDNA 398
    Primer pair 3

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36164, MGI:2442911
References
more
  • Summaries
    All 53
    Developmental Gene Expression 14
    Gene Ontology 6
    Phenotypes 10
  • Earliest
    J:17114 Valera A, et al., Overexpression of mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase in transgenic mice causes hepatic hyperketogenesis. J Biol Chem. 1994 Mar 4;269(9):6267-70
  • Latest
    J:264124 Tsushima H, et al., Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis. Development. 2018 Jul 9;145(13)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/04/2018
MGI 6.13
The Jackson Laboratory