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Irf9
Gene Detail
Symbol

Name
ID
Irf9
interferon regulatory factor 9
MGI:107587
Synonyms
Irf-9, Isgf3g, p48
Feature Type
protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:55603571-55610030 bp, + strand
From VEGA annotation of GRCm38

  6460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: IRF9
Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf9

Human
homologs
IRF9, interferon regulatory factor 9
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 10379
neXtProt AC: NX_Q00978

Human Synonyms: IRF-9, ISGF3, ISGF3G, p48

Human Chr (Location): 14q11.2; chr14:24161213-24166565 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, antivirus response induced by Ifn alfpha and Ifn gamma are impaired.
 
Interactions
Irf9 interacts with 143 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (229)    Tissues (191)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 183
RT-PCR 46
cDNA source data(68)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100487158 ; ZFIN irf9    NEW 
Molecular
reagents
All nucleic(71) cDNA(69) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000029027 (Evidence)
Ensembl Gene Model ENSMUSG00000002325 (Evidence)
Entrez Gene 16391 (Evidence)
UniGene 2032
DFCI TC1620291, TC1579330, TC1769692
NIA Mouse Gene Index U015661
Consensus CDS Project CCDS27119.1, CCDS49496.1, CCDS49497.1
International Mouse Phenotyping Consortium Status Irf9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029027 VEGA Gene Model | MGI Sequence Detail 6460 C57BL/6J ±  kb
transcript OTTMUST00000072013 VEGA | MGI Sequence Detail 2959 Not Applicable 
polypeptide OTTMUSP00000036983 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(4)
Polymorphisms
PCR(1) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002051 interferon regulatory factor 9
References
(Earliest) J:31901 Suhara W, et al., Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene. J Biochem. 1996 Feb;119(2):231-4
(Latest) J:216134 Chen HZ, et al., A critical role for interferon regulatory factor 9 in cerebral ischemic stroke. J Neurosci. 2014 Sep 3;34(36):11897-912
All references(60)
Other
accession IDs
MGD-MRK-36159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory