About   Help   FAQ
Irf9 Gene Detail
Summary
  • Symbol
    Irf9
  • Name
    interferon regulatory factor 9
  • Synonyms
    Irf-9, Isgf3g, p48
  • Feature Type
    protein coding gene
  • IDs
    MGI:107587
    NCBI Gene: 16391
  • Gene Overview
    MyGene.info: IRF9
Location & Maps
more
  • Sequence Map
    Chr14:55603571-55610030 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6460 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    IRF9, interferon regulatory factor 9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IRF9, interferon regulatory factor 9
    Orthology source: HomoloGene
  • Synonyms
    IRF-9, ISGF3, ISGF3G, p48
  • Links
    NCBI Gene ID: 10379
    neXtProt AC: NX_Q00978

  • Chr Location
    14q11.2; chr14:24161213-24166565 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    15
  • Targeted
    3
  • Genomic Mutations
    1 involving Irf9
  • Incidental Mutations
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, antivirus response induced by Ifn alfpha and Ifn gamma are impaired.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029027 VEGA Gene Model | MGI Sequence Detail 6460 C57BL/6J ±  kb
transcript OTTMUST00000072013 VEGA | MGI Sequence Detail 2959 Not Applicable  
polypeptide OTTMUSP00000036983 VEGA | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    16 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000002051 interferon regulatory factor 9
  • InterPro Domains
    IPR019471 Interferon regulatory factor-3
    IPR019817 Interferon regulatory factor, conserved site
    IPR001346 Interferon regulatory factor DNA-binding domain
    IPR017855 SMAD domain-like
    IPR008984 SMAD/FHA domain
    IPR011991 Winged helix-turn-helix DNA-binding domain
Molecular
Reagents
less
  • All nucleic 71
    cDNA 69
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36159
References
more
  • Summaries
    All 63
    Developmental Gene Expression 7
    Gene Ontology 6
    Phenotypes 31
  • Earliest
    J:31901 Suhara W, et al., Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene. J Biochem. 1996 Feb;119(2):231-4
  • Latest
    J:224890 Martinet V, et al., Type I interferons regulate eomesodermin expression and the development of unconventional memory CD8(+) T cells. Nat Commun. 2015;6:7089

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory