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Irf9
Gene Detail
 Symbol
Name
ID
Irf9
interferon regulatory factor 9
MGI:107587
Synonyms Irf-9, Isgf3g, p48
Feature Type protein coding gene
Genetic Map
Chromosome 14
28.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:55603571-55610030 bp, + strand
From VEGA annotation of GRCm38

  6460 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4436  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: interferon regulatory factor 3-9
Gene Tree: Irf9

Human
homologs
Human Homolog IRF9, interferon regulatory factor 9
NCBI Gene ID 10379
neXtProt AC  NX_Q00978
Human Synonyms  IRF-9, ISGF3, ISGF3G, p48
Human Chr (Location)  14q11.2; chr14:24161213-24166565 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(15) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene display an apparently normal phenotype. However, antivirus response induced by Ifn alfpha and Ifn gamma are impaired.
 
Interactions
Irf9 interacts with 143 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process regulation of transcription, DNA-templated, transcription, DNA-templated, ...
Component cytoplasm, nucleus
Function DNA binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (229)    Tissues (191)    Images (8)
Theiler Stages: 15, 16, 17, 21, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 183
RT-PCR 46
cDNA source data(68)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(71) cDNA(69) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000029027 (Evidence)
Ensembl Gene ModelENSMUSG00000002325 (Evidence)
Entrez Gene16391 (Evidence)
UniGene2032
DFCITC1579330, TC1620291, TC1769692
NIA Mouse Gene IndexU015661
Consensus CDS ProjectCCDS27119.1, CCDS49496.1, CCDS49497.1
International Mouse Knockout Project StatusIrf9
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029027 VEGA Gene Model | MGI Sequence Detail 6460 C57BL/6J ±  kb
transcript OTTMUST00000072013 VEGA | MGI Sequence Detail 2959 Not Applicable 
polypeptide OTTMUSP00000036983 VEGA | MGI Sequence Detail 465 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(6) UniProt(4)
Polymorphisms PCR(1) : SNPs within 2kb(16 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019471 Interferon regulatory factor-3
InterPro IPR019817 Interferon regulatory factor, conserved site
InterPro IPR001346 Interferon regulatory factor DNA-binding domain
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000002051 interferon regulatory factor 9
References (Earliest) J:31901 Suhara W, et al., Structure of mouse interferon stimulated gene factor 3 gamma (ISGF3 gamma/p48) cDNA and chromosomal localization of the gene. J Biochem. 1996 Feb;119(2):231-4
(Latest) J:205017 Dorner M, et al., Completion of the entire hepatitis C virus life cycle in genetically humanized mice. Nature. 2013 Sep 12;501(7466):237-41
All references(56)
Other
accession IDs
MGD-MRK-36159

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory