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Sipa1
Gene Detail
Symbol

Name
ID
Sipa1
signal-induced proliferation associated gene 1
MGI:107576
Synonyms
SPA-1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:5651185-5663707 bp, - strand
From Ensembl annotation of GRCm38

  12523 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SIPA1
Gene Tree: Sipa1

Human
homologs
SIPA1, signal-induced proliferation-associated 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6494
neXtProt AC: NX_Q96FS4

Human Synonyms: SPA1

Human Chr (Location): 11q13; chr11:65638107-65650930 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display chronic myelocytic leukemia in either the chronic phase or blast crisis.
 
Human Diseases Modeled in Mice Using Sipa1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Sipa1 interacts with 39 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process cellular response to water deprivation, regulation of cell cycle, ...
Component Golgi apparatus, nucleolus, ...
Function GTPase activator activity, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (11)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 11
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sipa1    NEW 
Molecular
reagents
All nucleic(84) Genomic(9) cDNA(75)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000056917 (Evidence)
Entrez Gene 20469 (Evidence)
UniGene 3072
DFCI TC1576369, TC1673818
DoTS DT.110856893, DT.533965, DT.91356030, DT.99858035, DT.99858038
NIA Mouse Gene Index U148703
Consensus CDS Project CCDS29474.1
International Mouse Phenotyping Consortium Status Sipa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056917 Ensembl Gene Model | MGI Sequence Detail 12523 C57BL/6J ±  kb
transcript ENSMUST00000071857 Ensembl | MGI Sequence Detail 3868 Not Applicable 
polypeptide ENSMUSP00000073618 Ensembl | MGI Sequence Detail 1038 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(16) UniProt(9)
Polymorphisms
RFLP(1) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR000331 Rap GTPase activating protein domain
Protein Ontology PR:000014880 signal-induced proliferation-associated protein 1
References
(Earliest) J:35455 Hattori M, et al., Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol. 1995 Jan;15(1):552-60
(Latest) J:153245 Shimatani K, et al., PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15807-12
All references(37)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory