Sipa1
Gene Detail

Symbol Name ID

Sipa1 signal-induced proliferation associated gene 1 MGI:107576

Synonyms

SPA-1

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr19:5651185-5663707 bp, - strand From NCBI annotation of GRCm38   12523 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Sipa1

Human homologs

Human Homolog		SIPA1, signal-induced proliferation-associated 1
NCBI Gene ID		6494
neXtProt AC		NX_Q96FS4
Human Synonyms		SPA1
Human Chr (Location)		11q13; chr11:65405578-65418391 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Gene trapped(1)
 

Homozygous null mice display chronic myelocytic leukemia in either the chronic phase or blast crisis.

 
Human Diseases Modeled Using Mouse Sipa1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	cellular response to water deprivation, regulation of cell cycle, ...
Component	nucleus, protein complex, ...
Function	GTPase activator activity, protein C-terminus binding

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (11)   
Theiler Stages: 26, 28

Assay Type	Results
Northern blot	11

cDNA source data(76)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(85) Genomic(9) cDNA(76)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000056917 (Evidence)
Entrez Gene	20469 (Evidence)
UniGene	3072
DFCI	TC1576369, TC1673818
DoTS	DT.110856893, DT.533965, DT.91356030, DT.99858035, DT.99858038
NIA Mouse Gene Index	U148703
Consensus CDS Project	CCDS29474.1
International Mouse Knockout Project Status	Sipa1

Sequences

Length	Strain/Species
genomic	20469	NCBI Gene Model | MGI Sequence Detail	12523	C57BL/6J
transcript	NM_001164481	RefSeq | MGI Sequence Detail	3868	C57BL/6
polypeptide	P46062	UniProt | EBI | MGI Sequence Detail	1037	Not Applicable

All sequences(57) RefSeq(10) UniProt(9)

Polymorphisms

RFLP(1) : SNPs(55 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001478	PDZ domain
InterPro	IPR000331	Rap/ran-GAP
Protein Ontology	PR:000014880	signal-induced proliferation-associated protein 1

Graphical View of Protein Domain Structure

References

(Earliest) J:35455 Hattori M, et al., Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol. 1995 Jan;15(1):552-60
(Latest) J:153245 Shimatani K, et al., PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15807-12
All references(37)

Other accession IDs

MGD-MRK-36148