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Sipa1
Gene Detail
 Symbol
Name
ID
Sipa1
signal-induced proliferation associated gene 1
MGI:107576
Synonyms SPA-1
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr19:5651185-5663707 bp, - strand
From NCBI annotation of GRCm38

  12523 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7940  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

Gene Tree: Sipa1

Human
homologs
Human Homolog SIPA1, signal-induced proliferation-associated 1
NCBI Gene ID 6494
neXtProt AC  NX_Q96FS4
Human Synonyms  SPA1
Human Chr (Location)  11q13; chr11:65638107-65650920 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Gene trapped(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display chronic myelocytic leukemia in either the chronic phase or blast crisis.
 
Human Diseases Modeled Using Mouse Sipa1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Sipa1 interacts with 39 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process cellular response to water deprivation, regulation of cell cycle, ...
Component nucleus, protein complex, ...
Function GTPase activator activity, protein C-terminus binding
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (11)    Tissues (11)   
Theiler Stages: 26, 28
Assay TypeResults
Northern blot 11
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(9) cDNA(75)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000056917 (Evidence)
Entrez Gene20469 (Evidence)
UniGene3072
DFCITC1576369, TC1673818
DoTSDT.110856893, DT.533965, DT.91356030, DT.99858035, DT.99858038
NIA Mouse Gene IndexU148703
Consensus CDS ProjectCCDS29474.1
International Mouse Knockout Project StatusSipa1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20469 NCBI Gene Model | MGI Sequence Detail 12523 C57BL/6J ±  kb
transcript NM_001164481 RefSeq | MGI Sequence Detail 3868 C57BL/6 
polypeptide P46062 UniProt | EBI | MGI Sequence Detail 1037 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(14) UniProt(9)
Polymorphisms RFLP(1) : SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001478 PDZ domain
InterPro IPR000331 Rap GTPase activating proteins domain
Protein Ontology PR:000014880 signal-induced proliferation-associated protein 1
Graphical View of Protein Domain Structure
References (Earliest) J:35455 Hattori M, et al., Molecular cloning of a novel mitogen-inducible nuclear protein with a Ran GTPase-activating domain that affects cell cycle progression. Mol Cell Biol. 1995 Jan;15(1):552-60
(Latest) J:153245 Shimatani K, et al., PD-1+ memory phenotype CD4+ T cells expressing C/EBPalpha underlie T cell immunodepression in senescence and leukemia. Proc Natl Acad Sci U S A. 2009 Sep 15;106(37):15807-12
All references(37)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-36148

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory