Cav2
Gene Detail

Symbol Name ID

Cav2 caveolin 2 MGI:107571

Feature Type

protein coding gene

Genetic Map

Chromosome 6

7.72 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:17281185-17289115 bp, + strand From VEGA annotation of GRCm38   7931 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:942  Vertebrate Homology Class
1 human; 1 mouse; 2 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cav2

Human homologs

Human Homolog		CAV2, caveolin 2
NCBI Gene ID		858
neXtProt AC		NX_P51636
Human Synonyms		CAV
Human Chr (Location)		7q31.1; chr7:116139655-116148595 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous targeted mutants displayed thickening of lung aveloar septa from proliferation of endothelium and fibrosis, ultimately causing the mice physical limitations. The lung phenotype is the same as that for Cav1 null mutants.

 

Gene Ontology (GO) classifications

All GO classifications: (51 annotations)

Process	caveola assembly, endocytosis, ...
Component	acrosomal membrane, caveola, ...
Function	D1 dopamine receptor binding, phosphoprotein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (6)   
Theiler Stages: 10, 18, 23, 24, 25

Assay Type	Results
Immunohistochemistry	2
Northern blot	4
Western blot	3

cDNA source data(42)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(44) Genomic(1) cDNA(43)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000024026 (Evidence)
Ensembl Gene Model	ENSMUSG00000000058 (Evidence)
Entrez Gene	12390 (Evidence)
UniGene	396075
DFCI	TC1575293, TC1592826, TC1685431
DoTS	DT.530405, DT.55246486, DT.97338772
Consensus CDS Project	CCDS19923.1
International Mouse Knockout Project Status	Cav2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000024026	VEGA Gene Model | MGI Sequence Detail	7931	C57BL/6J
transcript	OTTMUST00000058748	VEGA | MGI Sequence Detail	2733	Not Applicable
polypeptide	OTTMUSP00000028503	VEGA | MGI Sequence Detail	162	Not Applicable

All sequences(40) RefSeq(4) UniProt(3)

Polymorphisms

SNPs(96 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001612	Caveolin
InterPro	IPR018361	Caveolin, conserved site
Protein Ontology	PR:000005064	caveolin-2

References

(Earliest) J:30626 Scherer PE, et al., Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):131-5
(Latest) J:189648 Fusco C, et al., The E3-ubiquitin ligase TRIM50 interacts with HDAC6 and p62, and promotes the sequestration and clearance of ubiquitinated proteins into the aggresome. PLoS One. 2012;7(7):e40440
All references(61)

Other accession IDs

MGD-MRK-36143, MGI:2141409