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Cav2
Gene Detail
 Symbol
Name
ID
Cav2
caveolin 2
MGI:107571
Feature Type protein coding gene
Genetic Map
Chromosome 6
7.72 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:17281185-17289115 bp, + strand
From VEGA annotation of GRCm38

  7931 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:942  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Cav2

Human
homologs
Human Homolog CAV2, caveolin 2
NCBI Gene ID 858
neXtProt AC  NX_P51636
Human Synonyms  CAV
Human Chr (Location)  7q31.1; chr7:116499601-116508541 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Homozygous targeted mutants displayed thickening of lung aveloar septa from proliferation of endothelium and fibrosis, ultimately causing the mice physical limitations. The lung phenotype is the same as that for Cav1 null mutants.
 
Interactions
Cav2 interacts with 289 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (56 annotations)
Process caveola assembly, endocytosis, ...
Component acrosomal membrane, caveola, ...
Function D1 dopamine receptor binding, phosphoprotein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (9)    Tissues (6)   
Theiler Stages: 10, 18, 23, 24, 25
Assay TypeResults
Immunohistochemistry 2
Northern blot 4
Western blot 3
cDNA source data(42)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(44) Genomic(1) cDNA(43)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000024026 (Evidence)
Ensembl Gene ModelENSMUSG00000000058 (Evidence)
Entrez Gene12390 (Evidence)
UniGene396075
DFCITC1575293, TC1592826, TC1685431
DoTSDT.530405, DT.55246486, DT.97338772
Consensus CDS ProjectCCDS19923.1, CCDS71727.1
International Mouse Knockout Project StatusCav2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024026 VEGA Gene Model | MGI Sequence Detail 7931 C57BL/6J ±  kb
transcript OTTMUST00000058748 VEGA | MGI Sequence Detail 2733 Not Applicable 
polypeptide OTTMUSP00000028503 VEGA | MGI Sequence Detail 162 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(3)
Polymorphisms SNPs within 2kb(117 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001612 Caveolin
InterPro IPR018361 Caveolin, conserved site
Protein Ontology PR:000005064 caveolin-2
References (Earliest) J:30626 Scherer PE, et al., Identification, sequence, and expression of caveolin-2 defines a caveolin gene family. Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):131-5
(Latest) J:201740 Ludwig A, et al., Molecular composition and ultrastructure of the caveolar coat complex. PLoS Biol. 2013 Aug;11(8):e1001640
All references(62)
Other
accession IDs
MGD-MRK-36143, MGI:2141409

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory