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Epx Gene Detail
Summary
  • Symbol
    Epx
  • Name
    eosinophil peroxidase
  • Synonyms
    EPO
  • Feature Type
    protein coding gene
  • IDs
    MGI:107569
    NCBI Gene: 13861
  • Gene Overview
    MyGene.info: EPX
Location & Maps
more
  • Sequence Map
    Chr11:87864000-87875536 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      11537 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.25 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    EPX, eosinophil peroxidase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPX, eosinophil peroxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPO, EPP, EPXD, EPX-PEN
  • Links
    NCBI Gene ID: 8288
    neXtProt AC: NX_P11678

  • Chr Location
    17q22; chr17:58192728-58205174 (+)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Targeted
    10
  • Genomic Mutations
    4 involving Epx
  • Incidental Mutations
Targeted deletion of this gene results in ultrastructural changes of the eosinophil secondary granule but does not significantly alter the course of inflammation or development of allergic pulmonary pathologies in an ovalbumin-challenge model of pulmonary inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001435 VEGA Gene Model | MGI Sequence Detail 11537 C57BL/6J ±  kb
transcript OTTMUST00000002800 VEGA | MGI Sequence Detail 2689 Not Applicable  
polypeptide OTTMUSP00000001364 VEGA | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    141 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 20
    Genomic 3
    cDNA 16
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-36141
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 23
  • Earliest
    J:34899 Horton MA, et al., Cloning of the murine eosinophil peroxidase gene (mEPO): characterization of a conserved subgroup of mammalian hematopoietic peroxidases. J Leukoc Biol. 1996 Aug;60(2):285-94
  • Latest
    J:230692 Huang L, et al., Eosinophils mediate protective immunity against secondary nematode infection. J Immunol. 2015 Jan 1;194(1):283-90

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory