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Epx Gene Detail
Summary
  • Symbol
    Epx
  • Name
    eosinophil peroxidase
  • Synonyms
    EPO
  • Feature Type
    protein coding gene
  • IDs
    MGI:107569
    NCBI Gene: 13861
  • Gene Overview
    MyGene.info: EPX
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:87864000-87875536 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 52.25 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    141 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107569
protein coding gene Chr11:87863997-87875536 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018915
protein coding gene Chr11:89503228-89516192 (-)
A/J MGP_AJ_G0018882
protein coding gene Chr11:86058614-86069858 (-)
AKR/J MGP_AKRJ_G0018852
protein coding gene Chr11:88623533-88641709 (-)
BALB/cJ MGP_BALBcJ_G0018855
protein coding gene Chr11:86459326-86470566 (-)
C3H/HeJ MGP_C3HHeJ_G0018669
protein coding gene Chr11:88676399-88689296 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019307
protein coding gene Chr11:92218431-92230693 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016940
protein coding gene Chr11:83086501-83097576 (-)
CAST/EiJ MGP_CASTEiJ_G0018224
protein coding gene Chr11:89366520-89377715 (-)
CBA/J MGP_CBAJ_G0018640
protein coding gene Chr11:96107016-96120602 (-)
DBA/2J MGP_DBA2J_G0018748
protein coding gene Chr11:85610946-85622358 (-)
FVB/NJ MGP_FVBNJ_G0018737
protein coding gene Chr11:85117062-85128519 (-)
LP/J MGP_LPJ_G0018818
protein coding gene Chr11:90002628-90015264 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018764
protein coding gene Chr11:96146433-96158688 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019347
protein coding gene Chr11:88875140-88888039 (-)
PWK/PhJ MGP_PWKPhJ_G0017994
protein coding gene Chr11:86455370-86467107 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017787
protein coding gene Chr11:88431029-88442050 (-)
WSB/EiJ MGP_WSBEiJ_G0018275
protein coding gene Chr11:88763098-88779075 (-)



Homology
more
  • Human Ortholog
    EPX, eosinophil peroxidase
  • Vertebrate Orthologs
    7
  • Human Ortholog
    EPX, eosinophil peroxidase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPO, EPP, EPXD, EPX-PEN
  • Links
    NCBI Gene ID: 8288
    neXtProt AC: NX_P11678
    UniProt: P11678

  • Chr Location
    17q22; chr17:58192724-58205174 (+)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Targeted deletion of this gene results in ultrastructural changes of the eosinophil secondary granule but does not significantly alter the course of inflammation or development of allergic pulmonary pathologies in an ovalbumin-challenge model of pulmonary inflammation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000052234 Ensembl Gene Model | MGI Sequence Detail 11537 C57BL/6J ±  kb
transcript ENSMUST00000049768 Ensembl | MGI Sequence Detail 2689 Not Applicable  
polypeptide ENSMUSP00000050497 Ensembl | MGI Sequence Detail 716 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 3
    cDNA 17
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36141
References
more
  • Summaries
    All 56
    Developmental Gene Expression 2
    Diseases 1
    Gene Ontology 6
    Phenotypes 28
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:247754 Ochkur SI, et al., Frontline Science: Eosinophil-deficient MBP-1 and EPX double-knockout mice link pulmonary remodeling and airway dysfunction with type 2 inflammation. J Leukoc Biol. 2017 Sep;102(3):589-599

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory