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Nab1 Gene Detail
Summary
  • Symbol
    Nab1
  • Name
    Ngfi-A binding protein 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:107564
    NCBI Gene: 17936
  • Gene Overview
    MyGene.info: NAB1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:52457294-52500679 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 26.99 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    331 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107564
protein coding gene Chr1:52455849-52500679 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016008
protein coding gene Chr1:51964993-52012123 (-)
A/J MGP_AJ_G0015990
protein coding gene Chr1:50222490-50266199 (-)
AKR/J MGP_AKRJ_G0015946
protein coding gene Chr1:51293069-51339800 (-)
BALB/cJ MGP_BALBcJ_G0015947
protein coding gene Chr1:50040203-50090567 (-)
C3H/HeJ MGP_C3HHeJ_G0015779
protein coding gene Chr1:51690586-51735849 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016398
protein coding gene Chr1:54163050-54206731 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014126
protein coding gene Chr1:41592217-41635005 (+)
CAST/EiJ MGP_CASTEiJ_G0015360
protein coding gene Chr1:51176968-51224975 (-)
CBA/J MGP_CBAJ_G0015750
protein coding gene Chr1:55590320-55639090 (-)
DBA/2J MGP_DBA2J_G0015851
protein coding gene Chr1:49484938-49536178 (-)
FVB/NJ MGP_FVBNJ_G0015853
protein coding gene Chr1:48953214-48998472 (-)
LP/J MGP_LPJ_G0015922
protein coding gene Chr1:52450531-52494381 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015873
protein coding gene Chr1:58653337-58699332 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016446
protein coding gene Chr1:51411508-51454883 (-)
PWK/PhJ MGP_PWKPhJ_G0015146
protein coding gene Chr1:49353229-49397344 (-)
SPRET/EiJ MGP_SPRETEiJ_G0014926
protein coding gene Chr1:51074555-51121400 (-)
WSB/EiJ MGP_WSBEiJ_G0015423
protein coding gene Chr1:51228754-51275328 (-)



Homology
more
  • Human Ortholog
    NAB1, NGFI-A binding protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NAB1, NGFI-A binding protein 1
    Orthology source: HomoloGene, HGNC
  • Links
    NCBI Gene ID: 4664
    neXtProt AC: NX_Q13506
    UniProt: Q13506

  • Chr Location
    2q32.2; chr2:190648860-190692766 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4352
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NAB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    8 phenotype references
Homozygous null mice are viable and fertile with normal myelination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000002881 Ensembl Gene Model | MGI Sequence Detail 43386 C57BL/6J ±  kb
transcript ENSMUST00000069792 Ensembl | MGI Sequence Detail 3874 Not Applicable  
polypeptide ENSMUSP00000066696 Ensembl | MGI Sequence Detail 486 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 84
    Genomic 2
    cDNA 80
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36136
References
more
  • Summaries
    All 42
    Developmental Gene Expression 8
    Gene Ontology 5
    Phenotypes 8
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:205781 Kearney SJ, et al., Type I IFNs downregulate myeloid cell IFN-gamma receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription. J Immunol. 2013 Sep 15;191(6):3384-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory