Sema3b
Gene Detail

Symbol Name ID

Sema3b sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B MGI:107561

Synonyms

LUCA-1, SemA, SemA, sema5, Semaa, semaV

Feature Type

protein coding gene

Genetic Map

Chromosome 9

58.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:107597674-107609229 bp, - strand From VEGA annotation of GRCm38   11556 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3b

Human homologs

Human Homolog		SEMA3B, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
NCBI Gene ID		7869
neXtProt AC		NX_Q13214
Human Synonyms		LUCA-1, SemA, SEMA5, SEMAA, semaV
Human Chr (Location)		3p21.3; chr3:50305040-50314573 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(5) Gene trapped(1)
 

Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.

 

Gene Ontology (GO) classifications

All GO classifications: (7 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	extracellular region, membrane
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (28 records)
Data Summary: Results (98)    Tissues (73)    Images (24)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	90
Northern blot	8

cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(60) Genomic(4) cDNA(55) Other(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000016526 (Evidence)
Ensembl Gene Model	ENSMUSG00000057969 (Evidence)
Entrez Gene	20347 (Evidence)
UniGene	4083
DFCI	TC1577988, TC1692239, TC1701884
DoTS	DT.101159120, DT.101373803, DT.101717602, DT.60104418, DT.91559866, DT.97392815
NIA Mouse Gene Index	U031318
Consensus CDS Project	CCDS23501.1
International Mouse Knockout Project Status	Sema3b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016526	VEGA Gene Model | MGI Sequence Detail	11556	C57BL/6J
transcript	OTTMUST00000039941	VEGA | MGI Sequence Detail	3191	Not Applicable
polypeptide	OTTMUSP00000017808	VEGA | MGI Sequence Detail	749	Not Applicable

All sequences(70) RefSeq(4) UniProt(2)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014616	semaphorin-3B

References

(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(65)

Other accession IDs

MGD-MRK-36132, MGI:2143295