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Sema3b Gene Detail
Summary
  • Symbol
    Sema3b
  • Name
    sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
  • Synonyms
    LUCA-1, SemA, SemA, sema5, Semaa, semaV
  • Feature Type
    protein coding gene
  • IDs
    MGI:107561
    NCBI Gene: 20347
  • Gene Overview
    MyGene.info: SEMA3B
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:107597674-107609229 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 58.31 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107561
protein coding gene Chr9:107597674-107609299 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035264
protein coding gene Chr9:109484878-109496432 (-)
A/J MGP_AJ_G0035243
protein coding gene Chr9:105495561-105507132 (-)
AKR/J MGP_AKRJ_G0035175
protein coding gene Chr9:108128504-108140071 (-)
BALB/cJ MGP_BALBcJ_G0035237
protein coding gene Chr9:105164105-105175658 (-)
C3H/HeJ MGP_C3HHeJ_G0034947
protein coding gene Chr9:108526591-108538142 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035757
protein coding gene Chr9:112465339-112476892 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032655
protein coding gene Chr9:102924041-102935796 (-)
CAST/EiJ MGP_CASTEiJ_G0034258
protein coding gene Chr9:108460399-108471949 (-)
CBA/J MGP_CBAJ_G0034915
protein coding gene Chr9:116438385-116449931 (-)
DBA/2J MGP_DBA2J_G0035076
protein coding gene Chr9:104948343-104959900 (-)
FVB/NJ MGP_FVBNJ_G0035024
protein coding gene Chr9:103714924-103726523 (-)
LP/J MGP_LPJ_G0035152
protein coding gene Chr9:109680151-109691704 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035063
protein coding gene Chr9:118053972-118065522 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035778
protein coding gene Chr9:108402474-108414039 (-)
PWK/PhJ MGP_PWKPhJ_G0033965
protein coding gene Chr9:105269111-105280746 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033800
protein coding gene Chr9:108454198-108465717 (-)
WSB/EiJ MGP_WSBEiJ_G0034379
protein coding gene Chr9:108282220-108293741 (-)



Homology
more
  • Human Ortholog
    SEMA3B, semaphorin 3B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEMA3B, semaphorin 3B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    LUCA-1, SemA, SEMA5, SEMAA, semaV
  • Links
    NCBI Gene ID: 7869
    neXtProt AC: NX_Q13214
    UniProt: Q13214

  • Chr Location
    3p21.31; chr3:50267558-50277171 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 3 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000057969 Ensembl Gene Model | MGI Sequence Detail 11556 C57BL/6J ±  kb
    transcript ENSMUST00000102532 Ensembl | MGI Sequence Detail 3191 Not Applicable  
    polypeptide ENSMUSP00000099591 Ensembl | MGI Sequence Detail 749 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 4
      cDNA 57
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-36132, MGI:2143295
    References
    more
    • Summaries
      All 76
      Developmental Gene Expression 37
      Gene Ontology 3
      Phenotypes 13
    • Earliest
      J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory