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Sema3b
Gene Detail
Symbol

Name
ID
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
MGI:107561
Synonyms
LUCA-1, SemA, SemA, sema5, Semaa, semaV
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:107597674-107609229 bp, - strand
From VEGA annotation of GRCm38

  11556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEMA3B
Protein SuperFamily: semaphorin
Gene Tree: Sema3b

Human
homologs
SEMA3B, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7869
neXtProt AC: NX_Q13214

Human Synonyms: LUCA-1, SemA, SEMA5, SEMAA, semaV

Human Chr (Location): 3p21.3; chr3:50267558-50277171 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.
 
Interactions
Sema3b interacts with 87 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (6 annotations)
Process cell differentiation, multicellular organismal development, ...
Component extracellular exosome, extracellular region, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (98)    Tissues (73)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
Northern blot 8
cDNA source data(54)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sema3b    NEW 
Molecular
reagents
All nucleic(60) Genomic(4) cDNA(55) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000016526 (Evidence)
Ensembl Gene Model ENSMUSG00000057969 (Evidence)
Entrez Gene 20347 (Evidence)
UniGene 4083
DFCI TC1577988, TC1692239, TC1701884
DoTS DT.101159120, DT.101373803, DT.101717602, DT.60104418, DT.91559866, DT.97392815
NIA Mouse Gene Index U031318
Consensus CDS Project CCDS23501.1
International Mouse Phenotyping Consortium Status Sema3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016526 VEGA Gene Model | MGI Sequence Detail 11556 C57BL/6J ±  kb
transcript OTTMUST00000039941 VEGA | MGI Sequence Detail 3191 Not Applicable 
polypeptide OTTMUSP00000017808 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(137) RefSeq(35) UniProt(9)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR016201 Plexin-like fold
InterPro IPR002165 Plexin repeat
InterPro IPR001627 Sema domain
InterPro IPR027231 Semaphorin
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014616 semaphorin-3B
References
(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:221787 Arbeille E, et al., Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
All references(70)
Other
accession IDs
MGD-MRK-36132, MGI:2143295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory