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Sema3b
Gene Detail
Symbol

Name
ID
Sema3b
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
MGI:107561
Synonyms
LUCA-1, SemA, SemA, sema5, Semaa, semaV
Feature Type
protein coding gene
Genetic Map
Chromosome 9
58.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:107597674-107609229 bp, - strand
From VEGA annotation of GRCm38

  11556 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3b

Human
homologs
Human Homolog SEMA3B, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3B
NCBI Gene ID 7869
neXtProt AC  NX_Q13214
Human Synonyms  LUCA-1, SemA, SEMA5, SEMAA, semaV
Human Chr (Location)  3p21.3; chr3:50267608-50277142 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one knock-out allele are viable and fertile with no obvious pathological abnormalities. Mice homozygous for a second knock-out allele exhibit improper positioning of a major brain commissural projection, the anterior commissure.
 
Interactions
Sema3b interacts with 87 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (8 annotations)
Process cell differentiation, multicellular organismal development, ...
Component extracellular region, extracellular vesicular exosome, ...
Function receptor activity
External Resources: FuncBase
Expression
Literature Summary: (29 records)
Data Summary: Results (98)    Tissues (73)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 90
Northern blot 8
cDNA source data(54)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(60) Genomic(4) cDNA(55) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000016526 (Evidence)
Ensembl Gene ModelENSMUSG00000057969 (Evidence)
Entrez Gene20347 (Evidence)
UniGene4083
DFCITC1577988, TC1692239, TC1701884
DoTSDT.91559866, DT.101373803, DT.97392815, DT.60104418, DT.101159120, DT.101717602
NIA Mouse Gene IndexU031318
Consensus CDS ProjectCCDS23501.1
International Mouse Knockout Project StatusSema3b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016526 VEGA Gene Model | MGI Sequence Detail 11556 C57BL/6J ±  kb
transcript OTTMUST00000039965 VEGA | MGI Sequence Detail 2958 Not Applicable 
polypeptide OTTMUSP00000017818 VEGA | MGI Sequence Detail 749 Not Applicable 

For the selected sequences
All sequences(108) RefSeq(35) UniProt(7)
Polymorphisms
SNPs within 2kb(66 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014616 semaphorin-3B
References
(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:205955 Katayama K, et al., Deletion of Sema3a or plexinA1/plexinA3 causes defects in sensory afferent projections of statoacoustic ganglion neurons. PLoS One. 2013;8(8):e72512
All references(68)
Other
accession IDs
MGD-MRK-36132, MGI:2143295

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory