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Sema4a
Gene Detail
Symbol

Name
ID
Sema4a
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
MGI:107560
Synonyms
Semab, SemB, SemB
Feature Type
protein coding gene
Genetic Map
Chromosome 3
38.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:88435959-88459101 bp, - strand
From VEGA annotation of GRCm38

  23143 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: SEMA4A
Protein SuperFamily: semaphorin
Gene Tree: Sema4a

Human
homologs
SEMA4A, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 64218
neXtProt AC: NX_Q9H3S1

Human Synonyms: CORD10, RP35, SEMAB, SEMB

Human Chr (Location): 1q22; chr1:156147359-156177751 (+)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SEMA4A

Mutations,
alleles, and
phenotypes
All mutations/alleles(18) : Gene trapped(10) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a knock-out allele show no obvious brain defects but exhibit impaired T cell priming and defective Th1 responses. Homozygotes for a gene trap allele show severe retinal degeneration with reduced retinal vessels, depigmentation and dysfunction of both rod and cone photoreceptors.
 
Interactions
Sema4a interacts with 137 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process adaptive immune response, angiogenesis, ...
Component integral component of membrane, membrane, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (54)    Images (10)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 56
Northern blot 8
cDNA source data(81)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase sema4a    NEW 
Molecular
reagents
All nucleic(83) cDNA(82) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021258 (Evidence)
Ensembl Gene Model ENSMUSG00000028064 (Evidence)
Entrez Gene 20351 (Evidence)
UniGene 439752
DFCI TC1753295, TC1694557, TC1572841
DoTS DT.91350685, DT.493064, DT.101388240, DT.101388241, DT.97336049
NIA Mouse Gene Index U024253
Consensus CDS Project CCDS17475.1
International Mouse Phenotyping Consortium Status Sema4a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021258 VEGA Gene Model | MGI Sequence Detail 23143 C57BL/6J ±  kb
transcript OTTMUST00000050356 VEGA | MGI Sequence Detail 3205 Not Applicable 
polypeptide OTTMUSP00000023497 VEGA | MGI Sequence Detail 760 Not Applicable 

For the selected sequences
All sequences(114) RefSeq(22) UniProt(10)
Polymorphisms
SNPs within 2kb(47 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014622 semaphorin-4A
References
(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:205754 Nojima S, et al., A point mutation in Semaphorin 4A associates with defective endosomal sorting and causes retinal degeneration. Nat Commun. 2013;4:1406
All references(51)
Other
accession IDs
MGD-MRK-36131, MGI:2139635

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory