Sema4a
Gene Detail

Symbol Name ID

Sema4a sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A MGI:107560

Synonyms

Semab, SemB, SemB

Feature Type

protein coding gene

Genetic Map

Chromosome 3

38.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:88435959-88459101 bp, - strand From VEGA annotation of GRCm38   23143 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 2 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema4a

Human homologs

Human Homolog		SEMA4A, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
NCBI Gene ID		64218
neXtProt AC		NX_Q9H3S1
Human Synonyms		CORD10, RP35, SEMAB, SEMB
Human Chr (Location)		1q22; chr1:156119735-156147542 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SEMA4A

Alleles and phenotypes

All alleles(14) : Targeted(4) Gene trapped(10)
 

Homozygotes for a knock-out allele show no obvious brain defects but exhibit impaired T cell priming and defective Th1 responses. Homozygotes for a gene trap allele show severe retinal degeneration with reduced retinal vessels, depigmentation and dysfunction of both rod and cone photoreceptors.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	angiogenesis, axonogenesis, ...
Component	integral to membrane, membrane, ...
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (11 records)
Data Summary: Results (64)    Tissues (54)    Images (10)
Theiler Stages: 17, 19, 20, 21, 23, 24, 25, 28

Assay Type	Results
RNA in situ	56
Northern blot	8

cDNA source data(82)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(84) cDNA(83) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021258 (Evidence)
Ensembl Gene Model	ENSMUSG00000028064 (Evidence)
Entrez Gene	20351 (Evidence)
UniGene	439752
DFCI	TC1572841, TC1694557, TC1753295
DoTS	DT.101388240, DT.101388241, DT.493064, DT.91350685, DT.97336049
NIA Mouse Gene Index	U024253
Consensus CDS Project	CCDS17475.1
International Mouse Knockout Project Status	Sema4a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021258	VEGA Gene Model | MGI Sequence Detail	23143	C57BL/6J
transcript	OTTMUST00000050356	VEGA | MGI Sequence Detail	3205	Not Applicable
polypeptide	OTTMUSP00000023497	VEGA | MGI Sequence Detail	760	Not Applicable

All sequences(91) RefSeq(8) UniProt(7)

Polymorphisms

SNPs(44 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014622	semaphorin-4A

References

(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:188679 Nakatsuji Y, et al., Elevation of Sema4A implicates Th cell skewing and the efficacy of IFN-beta therapy in multiple sclerosis. J Immunol. 2012 May 15;188(10):4858-65
All references(50)

Other accession IDs

MGD-MRK-36131, MGI:2139635