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Sema4a Gene Detail
Summary
  • Symbol
    Sema4a
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
  • Synonyms
    Semab, SemB, SemB
  • Feature Type
    protein coding gene
  • IDs
    MGI:107560
    NCBI Gene: 20351
  • Alliance
  • Transcription Start Sites
    22 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:88343266-88368489 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 3, 38.83 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107560
protein coding gene Chr3:88343266-88368500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027397
protein coding gene Chr3:88594494-88617634 (-)
A/J MGP_AJ_G0027361
protein coding gene Chr3:85610401-85633555 (-)
AKR/J MGP_AKRJ_G0027325
protein coding gene Chr3:87721389-87746292 (-)
BALB/cJ MGP_BALBcJ_G0027370
protein coding gene Chr3:85694807-85717939 (-)
C3H/HeJ MGP_C3HHeJ_G0027112
protein coding gene Chr3:87979326-88002484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0027816
protein coding gene Chr3:91896509-91919651 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025168
protein coding gene Chr3:81208606-81234347 (-)
CAST/EiJ MGP_CASTEiJ_G0026558
protein coding gene Chr3:88211173-88239135 (-)
CBA/J MGP_CBAJ_G0027086
protein coding gene Chr3:95043599-95066576 (-)
DBA/2J MGP_DBA2J_G0027224
protein coding gene Chr3:85091556-85114583 (-)
FVB/NJ MGP_FVBNJ_G0027192
protein coding gene Chr3:83359848-83382883 (-)
LP/J MGP_LPJ_G0027333
protein coding gene Chr3:89608345-89631598 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027212
protein coding gene Chr3:101274757-101297899 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0027875
protein coding gene Chr3:87466709-87489849 (-)
PWK/PhJ MGP_PWKPhJ_G0026292
protein coding gene Chr3:84867931-84893727 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026111
protein coding gene Chr3:86642109-86667198 (-)
WSB/EiJ MGP_WSBEiJ_G0026640
protein coding gene Chr3:87814022-87843708 (-)



Homology
more
  • Human Ortholog
    SEMA4A, semaphorin 4A
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SEMA4A, semaphorin 4A
  • Synonyms
    CORD10, RP35, SEMAB, SEMB
  • Links
    NCBI Gene ID: 64218
    neXtProt AC: NX_Q9H3S1
    UniProt: Q9H3S1

  • Chr Location
    1q22; chr1:156147366-156177752 (+)  GRCh38

Human Diseases
more
  • Diseases
    2 with human SEMA4A associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    22 phenotypes from 7 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    30 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a knock-out allele show no obvious brain defects but exhibit impaired T cell priming and defective Th1 responses. Homozygotes for a gene trap allele show severe retinal degeneration with reduced retinal vessels, depigmentation and dysfunction of both rod and cone photoreceptors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028064 Ensembl Gene Model | MGI Sequence Detail 25224 C57BL/6J ±  kb
    transcript ENSMUST00000169222 Ensembl | MGI Sequence Detail 3084 Not Applicable  
    polypeptide ENSMUSP00000128887 Ensembl | MGI Sequence Detail 760 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 88
      cDNA 84
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36131, MGI:2139635
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 17
      Diseases 1
      Gene Ontology 6
      Phenotypes 30
    • Earliest
      J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
    • Latest
      J:335811 Naito Y, et al., Tumor-derived semaphorin 4A improves PD-1-blocking antibody efficacy by enhancing CD8(+) T cell cytotoxicity and proliferation. Sci Adv. 2023 May 19;9(20):eade0718

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory