Sema4b
Gene Detail

Symbol Name ID

Sema4b sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B MGI:107559

Synonyms

Semac, SemC

Feature Type

protein coding gene

Genetic Map

Chromosome 7

45.51 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:80186841-80226394 bp, + strand From VEGA annotation of GRCm38   39554 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema4b

Human homologs

Human Homolog		SEMA4B, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
NCBI Gene ID		10509
neXtProt AC		NX_Q9NPR2
Human Synonyms		SEMAC, SemC
Human Chr (Location)		15q25; chr15:90728152-90772892 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(343) : Targeted(7) Gene trapped(336)
 

Mice homozygous for a gene trap allele exhibit normal cerebellar morphology. Mice homozygous for a knock-out allele exhibit enhanced memory response by way of increased IgE and IgG1 serum levels.

 

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	cell differentiation, multicellular organismal development, ...
Component	integral to membrane, membrane
Function	receptor activity

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (39)    Tissues (38)    Images (8)
Theiler Stages: 17, 19, 20, 21, 23, 24, 25, 28

Assay Type	Results
RNA in situ	31
Northern blot	8

cDNA source data(16)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(17) cDNA(16) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021122 (Evidence)
Ensembl Gene Model	ENSMUSG00000030539 (Evidence)
Entrez Gene	20352 (Evidence)
UniGene	275909
DFCI	TC1585713, TC1592085, TC1662926
DoTS	DT.101359421, DT.102551708, DT.50315179, DT.87028395, DT.87057425
NIA Mouse Gene Index	U008276
Consensus CDS Project	CCDS21391.1
International Mouse Knockout Project Status	Sema4b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021122	VEGA Gene Model | MGI Sequence Detail	39554	C57BL/6J
transcript	OTTMUST00000050002	VEGA | MGI Sequence Detail	3816	Not Applicable
polypeptide	OTTMUSP00000023270	VEGA | MGI Sequence Detail	823	Not Applicable

All sequences(39) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR027231	Semaphorin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014623	semaphorin-4B

References

(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(48)

Other accession IDs

MGD-MRK-36130