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Sema4b
Gene Detail
Symbol

Name
ID
Sema4b
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
MGI:107559
Synonyms
Semac, SemC
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.51 cM, cytoband D2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:80186841-80226394 bp, + strand
From VEGA annotation of GRCm38

  39554 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8426  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: SEMA4B
Protein SuperFamily: semaphorin
Gene Tree: Sema4b

Human
homologs
SEMA4B, sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 10509
neXtProt AC: NX_Q9NPR2

Human Synonyms: SEMAC, SemC

Human Chr (Location): 15q25; chr15:90184920-90229664 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(343) : Gene trapped(336) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele exhibit normal cerebellar morphology. Mice homozygous for a knock-out allele exhibit enhanced memory response by way of increased IgE and IgG1 serum levels.
 
Interactions
Sema4b interacts with 202 markers (Mir1b, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process cell differentiation, multicellular organismal development, ...
Component integral component of membrane, membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (39)    Tissues (38)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 31
Northern blot 8
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase sema4b    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021122 (Evidence)
Ensembl Gene Model ENSMUSG00000030539 (Evidence)
Entrez Gene 20352 (Evidence)
UniGene 275909
DFCI TC1592085, TC1585713, TC1662926
DoTS DT.87028395, DT.50315179, DT.87057425, DT.101359421, DT.102551708
NIA Mouse Gene Index U008276
Consensus CDS Project CCDS21391.1
International Mouse Phenotyping Consortium Status Sema4b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021122 VEGA Gene Model | MGI Sequence Detail 39554 C57BL/6J ±  kb
transcript OTTMUST00000050002 VEGA | MGI Sequence Detail 3816 Not Applicable 
polypeptide OTTMUSP00000023270 VEGA | MGI Sequence Detail 823 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(257 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014623 semaphorin-4B
References
(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(46)
Other
accession IDs
MGD-MRK-36130

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory