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Sema4b Gene Detail
Summary
  • Symbol
    Sema4b
  • Name
    sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B
  • Synonyms
    Semac, SemC
  • Feature Type
    protein coding gene
  • IDs
    MGI:107559
    NCBI Gene: 20352
  • Gene Overview
    MyGene.info: SEMA4B
Location & Maps
more
  • Sequence Map
    Chr7:80186841-80226527 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      39687 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEMA4B, semaphorin 4B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEMA4B, semaphorin 4B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SEMAC, SemC
  • Links
    NCBI Gene ID: 10509
    neXtProt AC: NX_Q9NPR2

  • Chr Location
    15q25; chr15:90184920-90229664 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    344
  • Chemically induced (other)
    1
  • Gene trapped
    334
  • Radiation induced
    2
  • Targeted
    7
  • Genomic Mutations
    3 involving Sema4b
  • Incidental Mutations
Mice homozygous for a gene trap allele exhibit normal cerebellar morphology. Mice homozygous for a knock-out allele exhibit enhanced memory response by way of increased IgE and IgG1 serum levels.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021122 VEGA Gene Model | MGI Sequence Detail 39687 C57BL/6J ±  kb
transcript OTTMUST00000143999 VEGA | MGI Sequence Detail 3760 Not Applicable  
polypeptide OTTMUSP00000075080 VEGA | MGI Sequence Detail 823 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    253 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 18
    cDNA 17
    Other 1

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-36130
References
more
  • Summaries
    All 45
    Developmental Gene Expression 10
    Gene Ontology 3
    Phenotypes 24
  • Earliest
    J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
  • Latest
    J:225235 Azzarelli R, et al., An antagonistic interaction between PlexinB2 and Rnd3 controls RhoA activity and cortical neuron migration. Nat Commun. 2014;5:3405

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory