About   Help   FAQ
Sema3a
Gene Detail
 Symbol
Name
ID
Sema3a
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
MGI:107558
Synonyms collapsin-1, Semad, sema III, semaphorin III, SemD
Feature Type protein coding gene
Genetic Map
Chromosome 5
4.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr5:13396784-13602565 bp, + strand
From VEGA annotation of GRCm38

  205782 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31358  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3a

Human
homologs
Human Homolog SEMA3A, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
NCBI Gene ID 10371
neXtProt AC  NX_Q14563
Human Synonyms  coll-1, COLL1, HH16, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD
Human Chr (Location)  7p12.1; chr7:83958343-84492768 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human SEMA3A
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit patterning abnormalities of sensory and sympathetic neurons, abnormal embryonic bones and cartilaginous structures, cardiac defects, and high postnatal mortality.
 
Interactions
Sema3a interacts with 422 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process apoptotic process, axonal fasciculation, ...
Component axon, dendrite, ...
Function chemorepellent activity, neuropilin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (86 records)
Data Summary: Results (289)    Tissues (255)    Images (57)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 5
RNA in situ 271
Northern blot 8
RT-PCR 5
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(2) cDNA(22) Primer pair(3) Other(2)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000021298 (Evidence)
Ensembl Gene ModelENSMUSG00000028883 (Evidence)
Entrez Gene20346 (Evidence)
DFCITC1580481, TC1596640, TC1628192, TC1629532, TC1631240, TC1632021
DoTSDT.101231690, DT.101734768, DT.101734769, DT.110667889, DT.40158374, DT.40184457, DT.97389999
PDB4GZA, 1Q47, 4GZ8
Consensus CDS ProjectCCDS19092.1
International Mouse Knockout Project StatusSema3a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021298 VEGA Gene Model | MGI Sequence Detail 205782 C57BL/6J ±  kb
transcript OTTMUST00000050494 VEGA | MGI Sequence Detail 5930 Not Applicable 
polypeptide OTTMUSP00000023579 VEGA | MGI Sequence Detail 772 Not Applicable 

For the selected sequences
All sequences(69) RefSeq(12) UniProt(4)
Polymorphisms SNPs within 2kb(1220 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1222)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014615 semaphorin-3A
References (Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:210605 Molofsky AV, et al., Astrocyte-encoded positional cues maintain sensorimotor circuit integrity. Nature. 2014 May 8;509(7499):189-94
All references(167)
Other
accession IDs
MGD-MRK-36129

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory