Sema3a
Gene Detail

Symbol Name ID

Sema3a sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A MGI:107558

Synonyms

collapsin-1, Semad, sema III, semaphorin III, SemD

Feature Type

protein coding gene

Genetic Map

Chromosome 5

4.31 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr5:13396784-13602565 bp, + strand From VEGA annotation of GRCm38   205782 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31358  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3a

Human homologs

Human Homolog		SEMA3A, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3A
NCBI Gene ID		10371
neXtProt AC		NX_Q14563
Human Synonyms		coll-1, COLL1, Hsema-I, Hsema-III, SEMA1, SEMAD, SEMAIII, SEMAL, SemD
Human Chr (Location)		7p12.1; chr7:83587659-83824217 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SEMA3A

Alleles and phenotypes

All alleles(8) : Targeted(7) Chemically induced(1)
 

Homozygotes for targeted null mutations exhibit patterning abnormalities of sensory and sympathetic neurons, abnormal embryonic bones and cartilaginous structures, cardiac defects, and high postnatal mortality.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	apoptotic process, axonal fasciculation, ...
Component	axon, dendrite, ...
Function	chemorepellent activity, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (83 records)
Data Summary: Results (244)    Tissues (210)    Images (55)
Theiler Stages: 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	226
Northern blot	8
RT-PCR	5

cDNA source data(20)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) Genomic(2) cDNA(21) Primer pair(3) Other(2)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000021298 (Evidence)
Ensembl Gene Model	ENSMUSG00000028883 (Evidence)
Entrez Gene	20346 (Evidence)
DFCI	TC1580481, TC1596640, TC1628192, TC1629532, TC1631240, TC1632021
DoTS	DT.101231690, DT.101734768, DT.101734769, DT.110667889, DT.40158374, DT.97389999
NIA Mouse Gene Index	U005296
PDB	4GZA, 1Q47, 4GZ8
Consensus CDS Project	CCDS19092.1
International Mouse Knockout Project Status	Sema3a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021298	VEGA Gene Model | MGI Sequence Detail	205782	C57BL/6J
transcript	OTTMUST00000050495	VEGA | MGI Sequence Detail	4085	Not Applicable
polypeptide	OTTMUSP00000023580	VEGA | MGI Sequence Detail	772	Not Applicable

All sequences(62) RefSeq(6) UniProt(4)

Polymorphisms

SNPs(953 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR027231	Semaphorin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014615	semaphorin-3A

References

(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:195048 Li W, et al., Peripheral nerve-derived CXCL12 and VEGF-A regulate the patterning of arterial vessel branching in developing limb skin. Dev Cell. 2013 Feb 25;24(4):359-71
All references(156)

Other accession IDs

MGD-MRK-36129