Sema3c
Gene Detail

Symbol Name ID

Sema3c sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C MGI:107557

Synonyms

1110036B02Rik, Semae

Feature Type

protein coding gene

Genetic Map

Chromosome 5

7.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:17574281-17730268 bp, + strand From VEGA annotation of GRCm38   155988 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:36201  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema3c

Human homologs

Human Homolog		SEMA3C, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
NCBI Gene ID		10512
neXtProt AC		NX_Q99985
Human Synonyms		SEMAE, SemE
Human Chr (Location)		7q21-q31; chr7:80371854-80548667 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(2) Chemically induced(1)
 

Mice homozygous for an ENU mutation exhibit perinatal lethality, hypopigmentation and abnormal heart development. Mice homozygous for a knock-out allele exhibit prenatal lethality associated with heart defects.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	axon guidance, blood vessel remodeling, ...
Component	extracellular region, extracellular space, ...
Function	receptor activity, semaphorin receptor binding

External Resources: FuncBase

Expression

Literature Summary: (58 records)
Data Summary: Results (234)    Tissues (188)    Images (76)
Theiler Stages: 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	220
Northern blot	8
RT-PCR	6

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(28) cDNA(21) Primer pair(5) Other(2)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000035305 (Evidence)
Ensembl Gene Model	ENSMUSG00000028780 (Evidence)
Entrez Gene	20348 (Evidence)
DFCI	TC1577356, TC1606676
DoTS	DT.97410440, DT.97410442
NIA Mouse Gene Index	U005313
Consensus CDS Project	CCDS19099.1
International Mouse Knockout Project Status	Sema3c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035305	VEGA Gene Model | MGI Sequence Detail	155988	C57BL/6J
transcript	OTTMUST00000090077	VEGA | MGI Sequence Detail	5491	Not Applicable
polypeptide	OTTMUSP00000049340	VEGA | MGI Sequence Detail	751	Not Applicable

All sequences(40) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(961 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014617	semaphorin-3C

References

(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(93)

Other accession IDs

MGD-MRK-36128, MGI:1915946