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Sema3c
Gene Detail
Symbol

Name
ID
Sema3c
sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
MGI:107557
Synonyms
1110036B02Rik, Semae
Feature Type
protein coding gene
Genetic Map
Chromosome 5
7.99 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:17574281-17730268 bp, + strand
From VEGA annotation of GRCm38

  155988 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:36201  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEMA3C
Protein SuperFamily: semaphorin
Gene Tree: Sema3c

Human
homologs
SEMA3C, sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 10512
neXtProt AC: NX_Q99985

Human Synonyms: SEMAE, SemE

Human Chr (Location): 7q21-q31; chr7:80742538-80919351 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Chemically induced (ENU)(1) Targeted(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for an ENU mutation exhibit perinatal lethality, hypopigmentation and abnormal heart development. Mice homozygous for a knock-out allele exhibit prenatal lethality associated with heart defects.
 
Interactions
Sema3c interacts with 339 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process axon guidance, blood vessel remodeling, ...
Component extracellular exosome, extracellular region, ...
Function semaphorin receptor binding
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (307)    Tissues (260)    Images (82)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 293
Northern blot 8
RT-PCR 6
cDNA source data(20)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SEMA3C ; Xenbase sema3c ; ZFIN sema3c    NEW 
Molecular
reagents
All nucleic(30) cDNA(22) Primer pair(5) Other(3)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000035305 (Evidence)
Ensembl Gene Model ENSMUSG00000028780 (Evidence)
Entrez Gene 20348 (Evidence)
DFCI TC1577356, TC1606676
DoTS DT.97410440, DT.97410442
NIA Mouse Gene Index U005313
Consensus CDS Project CCDS19099.1
International Mouse Phenotyping Consortium Status Sema3c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035305 VEGA Gene Model | MGI Sequence Detail 155988 C57BL/6J ±  kb
transcript OTTMUST00000090077 VEGA | MGI Sequence Detail 5491 Not Applicable 
polypeptide OTTMUSP00000049340 VEGA | MGI Sequence Detail 751 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(1216 from dbSNP Build 137)    SNPs within 2kb including multiple locations(1220)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014617 semaphorin-3C
References
(Earliest) J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
(Latest) J:217604 Lavado A, et al., The tumor suppressor Nf2 regulates corpus callosum development by inhibiting the transcriptional coactivator Yap. Development. 2014 Nov;141(21):4182-93
All references(104)
Other
accession IDs
MGD-MRK-36128, MGI:1915946

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory