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Sema5a
Gene Detail
Symbol

Name
ID
Sema5a
sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
MGI:107556
Synonyms
9130201M22Rik, M-Sema D, Semaf, semF
Feature Type
protein coding gene
Genetic Map
Chromosome 15
13.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr15:32244813-32696341 bp, + strand
From NCBI annotation of GRCm38

  451529 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2949  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Sema5a

Human
homologs
Human Homolog SEMA5A, sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
NCBI Gene ID 9037
neXtProt AC  NX_Q13591
Human Synonyms  SEMAF, semF
Human Chr (Location)  5p15.2; chr5:9035026-9546121 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one null mutation die during organogenesis and display defects in branching of cranial vessels. Mice homozygous for another null mutation appear normal.
 
Interactions
Sema5a interacts with 531 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (25 records)
Data Summary: Results (577)    Tissues (453)    Images (105)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 383
In situ reporter (knock in) 114
Northern blot 27
Western blot 14
RT-PCR 39
cDNA source data(64)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(73) cDNA(70) Primer pair(3)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000022231 (Evidence)
Entrez Gene20356 (Evidence)
UniGene260374
DFCITC1585147, TC1587609, TC1599505, TC1656058, TC1669534
DoTSDT.110820940, DT.40179421, DT.87039503, DT.94251089
NIA Mouse Gene IndexU016139
Consensus CDS ProjectCCDS37055.1
International Mouse Knockout Project StatusSema5a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20356 NCBI Gene Model | MGI Sequence Detail 451529 C57BL/6J ±  kb
transcript NM_009154 RefSeq | MGI Sequence Detail 10809 C57BL/6 
polypeptide Q62217 UniProt | EBI | MGI Sequence Detail 1077 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(4839 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4841)
Protein-related
information
ResourceIDDescription
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR000884 Thrombospondin, type 1 repeat
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000014627 semaphorin-5A
Graphical View of Protein Domain Structure
References
(Earliest) J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
(Latest) J:207231 Nishino J, et al., A network of heterochronic genes including Imp1 regulates temporal changes in stem cell properties. Elife. 2013;2:e00924
All references(64)
Other
accession IDs
MGD-MRK-36127, MGI:2146024, MGI:2445048

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory