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Sema5a Gene Detail
Summary
  • Symbol
    Sema5a
  • Name
    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A
  • Synonyms
    9130201M22Rik, M-Sema D, Semaf, semF
  • Feature Type
    protein coding gene
  • IDs
    MGI:107556
    NCBI Gene: 20356
  • Gene Overview
    MyGene.info: SEMA5A
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:32244810-32696341 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 15, 13.02 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4814 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107556
protein coding gene Chr15:32244742-32696341 (.)
129S1/SvImJ MGP_129S1SvImJ_G0021771
protein coding gene Chr15:30547959-31013422 (+)
A/J MGP_AJ_G0021732
protein coding gene Chr15:29317672-29767095 (+)
AKR/J MGP_AKRJ_G0021709
protein coding gene Chr15:30061316-30522934 (+)
BALB/cJ MGP_BALBcJ_G0021738
protein coding gene Chr15:29312997-29766096 (+)
C3H/HeJ MGP_C3HHeJ_G0021513
protein coding gene Chr15:30087953-30547532 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022177
protein coding gene Chr15:31734538-32200605 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019715
protein coding gene Chr15:27361471-27804896 (+)
CAST/EiJ MGP_CASTEiJ_G0021029
protein coding gene Chr15:30684751-31046656 (+)
CBA/J MGP_CBAJ_G0021482
protein coding gene Chr15:32629071-33114962 (+)
DBA/2J MGP_DBA2J_G0021606
protein coding gene Chr15:29114827-29564903 (+)
FVB/NJ MGP_FVBNJ_G0021584
protein coding gene Chr15:28617885-29062796 (+)
LP/J MGP_LPJ_G0021675
protein coding gene Chr15:30435349-30906551 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0021609
protein coding gene Chr15:35621654-36092723 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022200
protein coding gene Chr15:30290638-30758309 (+)
PWK/PhJ MGP_PWKPhJ_G0020773
protein coding gene Chr15:29261128-29716014 (+)
SPRET/EiJ MGP_SPRETEiJ_G0020611
protein coding gene Chr15:30068458-30564543 (+)
WSB/EiJ MGP_WSBEiJ_G0021085
protein coding gene Chr15:30268506-30741721 (+)



Homology
more
  • Human Ortholog
    SEMA5A, semaphorin 5A
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEMA5A, semaphorin 5A
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SEMAF, semF
  • Links
    NCBI Gene ID: 9037
    neXtProt AC: NX_Q13591
    UniProt: Q13591

  • Chr Location
    5p15.31; chr5:9035026-9546121 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one null mutation die during organogenesis and display defects in branching of cranial vessels. Mice homozygous for another null mutation appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000022231 Ensembl Gene Model | MGI Sequence Detail 451532 C57BL/6J ±  kb
    transcript ENSMUST00000067458 Ensembl | MGI Sequence Detail 10809 Not Applicable  
    polypeptide ENSMUSP00000069024 Ensembl | MGI Sequence Detail 1074 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 76
      cDNA 72
      Primer pair 3
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-36127, MGI:2146024, MGI:2445048
    References
    more
    • Summaries
      All 71
      Developmental Gene Expression 30
      Gene Ontology 9
      Phenotypes 13
    • Earliest
      J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory