Sema5a
Gene Detail

Symbol Name ID

Sema5a sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A MGI:107556

Synonyms

9130201M22Rik, M-Sema D, Semaf, semF

Feature Type

protein coding gene

Genetic Map

Chromosome 15

13.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr15:32244813-32696341 bp, + strand From NCBI annotation of GRCm38   451529 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Sema5a ± 2 cM)

Gene Tree: Sema5a

Human ortholog

SEMA5A sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5A NCBI Gene ID 9037
Human Synonyms: SEMAF, semF
Human Chr5:9035138-9546233 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Mice homozygous for one null mutation die during organogenesis and display defects in branching of cranial vessels. Mice homozygous for another null mutation appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	axon guidance, branching morphogenesis of an epithelial tube, ...
Component	integral to membrane, membrane
Function	axon guidance receptor activity, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (547)    Tissues (416)    Images (103)
Theiler Stages: 11, 12, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	353
In situ reporter (knock in)	114
Northern blot	27
Western blot	14
RT-PCR	39

cDNA source data(63)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(72) cDNA(69) Primer pair(3)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000022231 (Evidence)
Entrez Gene	20356 (Evidence)
UniGene	260374
DFCI	TC1585147, TC1587609, TC1599505, TC1656058, TC1669534
DoTS	DT.110820940, DT.40179421, DT.87039503, DT.94251089
NIA Mouse Gene Index	U016139
Consensus CDS Project	CCDS37055.1
International Mouse Knockout Project Status	Sema5a

Sequences

Length	Strain/Species
genomic	20356	NCBI Gene Model | MGI Sequence Detail	451529	C57BL/6J
transcript	NM_009154	RefSeq | MGI Sequence Detail	10809	C57BL/6
polypeptide	Q62217	UniProt | EBI | MGI Sequence Detail	1077	Not Applicable

All sequences(36) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(2987 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR000884	Thrombospondin, type 1 repeat
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000014627	semaphorin-5A

Graphical View of Protein Domain Structure

References

(Earliest) J:28378 Inagaki S, et al., Identification of a member of mouse semaphorin family. FEBS Lett. 1995 Aug 21;370(3):269-72
(Latest) J:176977 Gunn RK, et al., Are Sema5a mutant mice a good model of autism? A behavioral analysis of sensory systems, emotionality and cognition. Behav Brain Res. 2011 Nov 20;225(1):142-50
All references(57)

Other accession IDs

MGD-MRK-36127, MGI:2146024, MGI:2445048