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Sema5b Gene Detail
Summary
  • Symbol
    Sema5b
  • Name
    sema domain, seven thrombospondin repeats (type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 5B
  • Synonyms
    mKIAA1445, Semag, SemG, SemG
  • Feature Type
    protein coding gene
  • IDs
    MGI:107555
    NCBI Gene: 20357
Location & Maps
more
  • Sequence Map
    Chr16:35541145-35664732 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      123588 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 25.37 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    SEMA5B, semaphorin 5B
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SEMA5B, semaphorin 5B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SEMAG, SemG
  • Links
    NCBI Gene ID: 54437
    neXtProt AC: NX_Q9P283
    UniProt: Q9P283

  • Chr Location
    3q21.1; chr3:122909193-123028605 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 3 genetic backgrounds
    11 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display defects in neurite arborization of multiple retinal cell types.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027281 VEGA Gene Model | MGI Sequence Detail 123588 C57BL/6J ±  kb
transcript OTTMUST00000067431 VEGA | MGI Sequence Detail 4646 Not Applicable  
polypeptide OTTMUSP00000033933 VEGA | MGI Sequence Detail 1122 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1020 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-36126, MGI:2146519
References
more
  • Summaries
    All 51
    Developmental Gene Expression 17
    Gene Ontology 2
    Phenotypes 11
  • Earliest
    J:25500 Puschel AW, et al., Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. Neuron. 1995 May;14(5):941-8
  • Latest
    J:229226 Amaniti EM, et al., Expansion of the piriform cortex contributes to corticothalamic pathfinding defects in Gli3 conditional mutants. Cereb Cortex. 2015 Feb;25(2):460-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
03/21/2017
MGI 6.08
The Jackson Laboratory