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Traf5
Gene Detail
Symbol

Name
ID
Traf5
TNF receptor-associated factor 5
MGI:107548
Feature Type
protein coding gene
Genetic Map
Chromosome 1
97.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:191997205-192059162 bp, - strand
From VEGA annotation of GRCm38

  61958 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TRAF5
Protein SuperFamily: TNF receptor-associated factor (TRAF)
Gene Tree: Traf5

Human
homologs
TRAF5, TNF receptor-associated factor 5
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 7188
neXtProt AC: NX_O00463

Human Synonyms: MGC:39780, RNF84

Human Chr (Location): 1q32; chr1:211326579-211374946 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally.
 
Interactions
Traf5 interacts with 1 marker (Mir466l)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, positive regulation of cell proliferation, ...
Component CD40 receptor complex, centrosome, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (17)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 34
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100491604    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000050773 (Evidence)
Ensembl Gene Model ENSMUSG00000026637 (Evidence)
Entrez Gene 22033 (Evidence)
DFCI TC1647498, TC1582318, TC1767522
DoTS DT.101204702, DT.97405273, DT.97363504, DT.101233251
NIA Mouse Gene Index U022209
PDB 4GJH
International Mouse Phenotyping Consortium Status Traf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000050773 VEGA Gene Model | MGI Sequence Detail 61958 C57BL/6J ±  kb
transcript OTTMUST00000128694 VEGA | MGI Sequence Detail 976 Not Applicable 
polypeptide OTTMUSP00000069210 VEGA | MGI Sequence Detail 250 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002083 MATH
InterPro IPR013323 SIAH-type domain
InterPro IPR027130 TNF receptor-associated factor 5
InterPro IPR012227 TNF receptor-associated factor TRAF
InterPro IPR008974 TRAF-like
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
InterPro IPR001293 Zinc finger, TRAF-type
Protein Ontology PR:000002291 TNF receptor-associated factor 5
References
(Earliest) J:33749 Nakano H, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996 Jun 21;271(25):14661-4
(Latest) J:209978 Nagashima H, et al., The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol. 2014 May;15(5):449-56
All references(53)
Other
accession IDs
MGD-MRK-36119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory