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Traf5
Gene Detail
 Symbol
Name
ID
Traf5
TNF receptor-associated factor 5
MGI:107548
Feature Type protein coding gene
Genetic Map
Chromosome 1
97.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr1:191997430-192092559 bp, - strand
From Ensembl annotation of GRCm38

  95130 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:27079  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: TNF receptor-associated factor (TRAF)
Gene Tree: Traf5

Human
homologs
Human Homolog TRAF5, TNF receptor-associated factor 5
NCBI Gene ID 7188
neXtProt AC  NX_O00463
Human Synonyms  MGC:39780, RNF84
Human Chr (Location)  1q32; chr1:211326526-211375061 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally.
 
Interactions
Traf5 interacts with 1 marker (Mir466l)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, positive regulation of cell proliferation, ...
Component CD40 receptor complex, centrosome, ...
Function metal ion binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (34)    Tissues (17)    Images (7)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026637 (Evidence)
Entrez Gene22033 (Evidence)
DFCITC1582318, TC1647498, TC1767522
DoTSDT.101204702, DT.101233251, DT.97363504, DT.97405273
NIA Mouse Gene IndexU022209
PDB4GJH
International Mouse Knockout Project StatusTraf5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026637 Ensembl Gene Model | MGI Sequence Detail 95130 C57BL/6J ±  kb
transcript ENSMUST00000085573 Ensembl | MGI Sequence Detail 1964 Not Applicable 
polypeptide ENSMUSP00000082710 Ensembl | MGI Sequence Detail 552 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(2) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002083 MATH
InterPro IPR013323 SIAH-type domain
InterPro IPR027130 TNF receptor-associated factor 5
InterPro IPR012227 TNF receptor-associated factor TRAF
InterPro IPR008974 TRAF-like
InterPro IPR018957 Zinc finger, C3HC4 RING-type
InterPro IPR013083 Zinc finger, RING/FYVE/PHD-type
InterPro IPR001841 Zinc finger, RING-type
InterPro IPR017907 Zinc finger, RING-type, conserved site
InterPro IPR001293 Zinc finger, TRAF-type
Protein Ontology PR:000002291 TNF receptor-associated factor 5
References (Earliest) J:33749 Nakano H, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996 Jun 21;271(25):14661-4
(Latest) J:209978 Nagashima H, et al., The adaptor TRAF5 limits the differentiation of inflammatory CD4(+) T cells by antagonizing signaling via the receptor for IL-6. Nat Immunol. 2014 May;15(5):449-56
All references(54)
Other
accession IDs
MGD-MRK-36119

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory