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Traf5 Gene Detail
Summary
  • Symbol
    Traf5
  • Name
    TNF receptor-associated factor 5
  • Feature Type
    protein coding gene
  • IDs
    MGI:107548
    NCBI Gene: 22033
  • Gene Overview
    MyGene.info: TRAF5
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:191997205-192092559 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 97.11 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    360 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107548
protein coding gene Chr1:191997203-192092599 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016951
protein coding gene Chr1:199074035-199120790 (-)
A/J MGP_AJ_G0016930
protein coding gene Chr1:190903019-190950868 (-)
AKR/J MGP_AKRJ_G0016895
protein coding gene Chr1:196577599-196628772 (-)
BALB/cJ MGP_BALBcJ_G0016888
protein coding gene Chr1:191580653-191628815 (-)
C3H/HeJ MGP_C3HHeJ_G0016712
protein coding gene Chr1:197421132-197474484 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017351
protein coding gene Chr1:205437396-205490906 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015058
protein coding gene Chr1:181799286-181849556 (-)
CAST/EiJ MGP_CASTEiJ_G0016295
protein coding gene Chr1:197023490-197074639 (-)
CBA/J MGP_CBAJ_G0016686
protein coding gene Chr1:213039237-213091893 (-)
DBA/2J MGP_DBA2J_G0016792
protein coding gene Chr1:189625824-189676400 (-)
FVB/NJ MGP_FVBNJ_G0016788
protein coding gene Chr1:187752061-187798809 (-)
LP/J MGP_LPJ_G0016867
protein coding gene Chr1:200258497-200309965 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016820
protein coding gene Chr1:219675624-219725451 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017388
protein coding gene Chr1:196456851-196503515 (-)
PWK/PhJ MGP_PWKPhJ_G0016082
protein coding gene Chr1:188927660-188975616 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015858
protein coding gene Chr1:195459288-195505106 (-)
WSB/EiJ MGP_WSBEiJ_G0016357
protein coding gene Chr1:196695286-196746229 (-)



Homology
more
  • Human Ortholog
    TRAF5, TNF receptor associated factor 5
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRAF5, TNF receptor associated factor 5
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MGC:39780, RNF84
  • Links
    NCBI Gene ID: 7188
    neXtProt AC: NX_O00463
    UniProt: O00463

  • Chr Location
    1q32.3; chr1:211326587-211374946 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice show defects in lymphocyte activation but are otherwise viable and develop normally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    • All Sequences
    • RefSeq
    • UniProt
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026637 Ensembl Gene Model | MGI Sequence Detail 95355 C57BL/6J ±  kb
    transcript ENSMUST00000085573 Ensembl | MGI Sequence Detail 1964 Not Applicable  
    polypeptide ENSMUSP00000082710 Ensembl | MGI Sequence Detail 552 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 15

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-36119
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 2
      Gene Ontology 12
      Phenotypes 16
    • Earliest
      J:33749 Nakano H, et al., TRAF5, an activator of NF-kappaB and putative signal transducer for the lymphotoxin-beta receptor. J Biol Chem. 1996 Jun 21;271(25):14661-4
    • Latest
      J:249864 Zhang L, et al., TRAF2 exerts opposing effects on basal and TNFalpha-induced activation of the classic IKK complex in hematopoietic cells in mice. J Cell Sci. 2016 Apr 01;129(7):1455-67

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory