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Klrb1a Gene Detail
Summary
  • Symbol
    Klrb1a
  • Name
    killer cell lectin-like receptor subfamily B member 1A
  • Synonyms
    Ly55a, Nkrp1-a, NKR-P1A
  • Feature Type
    protein coding gene
  • IDs
    MGI:107540
    NCBI Gene: 17057
  • Gene Overview
    MyGene.info: KLRB1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128609227-128622934 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.06 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    166 from dbSNP Build 142
  • Strain Annotations
    16
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107540
protein coding gene Chr6:128609227-128623533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031330
protein coding gene Chr6:132241806-132256123 (-)
A/J MGP_AJ_G0031301
protein coding gene Chr6:127156772-127168920 (-)
AKR/J MGP_AKRJ_G0031229
protein coding gene Chr6:130580457-130603832 (-)
BALB/cJ MGP_BALBcJ_G0031308
protein coding gene Chr6:126735498-126759146 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031767
protein coding gene Chr6:135670981-135689022 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028917
protein coding gene Chr6:124679572-124681918 (-)
CAST/EiJ MGP_CASTEiJ_G0030413
protein coding gene Chr6:131032034-131207169 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031149
protein coding gene Chr6:126057479-126291637 (-)
FVB/NJ MGP_FVBNJ_G0031099
protein coding gene Chr6:124981029-124996441 (-)
LP/J MGP_LPJ_G0031229
protein coding gene Chr6:132352977-132366895 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031137
protein coding gene Chr6:144742171-145008898 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031800
protein coding gene Chr6:130597412-130613389 (-)
PWK/PhJ MGP_PWKPhJ_G0030128
protein coding gene Chr6:124359802-124553758 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029959
protein coding gene Chr6:128888647-128890939 (+)
WSB/EiJ MGP_WSBEiJ_G0030498
protein coding gene Chr6:131010207-131020386 (-)



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKRP1A, NKR-P1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9595274-9607901 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 17057 NCBI Gene Model | MGI Sequence Detail 13708 C57BL/6J ±  kb
transcript NM_010737 RefSeq | MGI Sequence Detail 1284 C57BL/6  
polypeptide P27811 UniProt | EBI | MGI Sequence Detail 227 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 15
    Genomic 8
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36110
References
more
  • Summaries
    All 37
    Gene Ontology 2
    Phenotypes 4
  • Earliest
    J:12581 Yokoyama WM, et al., cDNA cloning of mouse NKR-P1 and genetic linkage with LY-49. Identification of a natural killer cell gene complex on mouse chromosome 6. J Immunol. 1991 Nov 1;147(9):3229-36
  • Latest
    J:241359 Aguilar OA, et al., A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell. 2017 Mar 23;169(1):58-71.e14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory