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Klrb1b Gene Detail
Summary
  • Symbol
    Klrb1b
  • Name
    killer cell lectin-like receptor subfamily B member 1B
  • Synonyms
    Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D
  • Feature Type
    protein coding gene
  • IDs
    MGI:107539
    NCBI Gene: 80782
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr6:128790669-128803278 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 63.09 cM, cytoband F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    233 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107539
 protein coding gene Chr6:128790669-128803294 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031335
 protein coding gene Chr6:132467050-132480796 (-)
A/J MGP_AJ_G0031306
 protein coding gene Chr6:127394226-127408976 (-)
AKR/J MGP_AKRJ_G0031234
 protein coding gene Chr6:130843984-130858537 (-)
BALB/cJ MGP_BALBcJ_G0031313
 protein coding gene Chr6:126986529-127000579 (-)
C3H/HeJ MGP_C3HHeJ_G0031037
 protein coding gene Chr6:131028321-131046147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031772
 protein coding gene Chr6:135935973-135950338 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028918
 protein coding gene Chr6:124713599-124728298 (-)
CAST/EiJ MGP_CASTEiJ_G0030417
 protein coding gene Chr6:131234729-131247519 (-)
CBA/J MGP_CBAJ_G0030998
 protein coding gene Chr6:141217565-141250104 (-)
DBA/2J MGP_DBA2J_G0031154
 protein coding gene Chr6:126319300-126350805 (-)
FVB/NJ MGP_FVBNJ_G0031104
 protein coding gene Chr6:125222718-125236233 (-)
LP/J MGP_LPJ_G0031236
 protein coding gene Chr6:132643142-132663720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031142
 protein coding gene Chr6:145066886-145087633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031805
 protein coding gene Chr6:130870765-130884751 (-)
PWK/PhJ MGP_PWKPhJ_G0030132
 protein coding gene Chr6:124544571-124601849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029961
 protein coding gene Chr6:128963082-128982270 (-)
WSB/EiJ MGP_WSBEiJ_G0030503
 protein coding gene Chr6:131206543-131277439 (-)



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKRP1A, NKR-P1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9594551-9607916 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal NK cell phsyiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    13
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 80782 NCBI Gene Model | MGI Sequence Detail 12610 C57BL/6J ±  kb
transcript NM_030599 RefSeq | MGI Sequence Detail 2212 ZRU/MplStud  
polypeptide P27812 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • PDB
    5TZN, 6E7D
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
Molecular
Reagents
less
  • All nucleic 18
    Genomic 5
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-36109, MGI:1931428
References
more
  • Summaries
    All 37
    Gene Ontology 6
    Phenotypes 6
  • Earliest
    J:35067 Giorda R, et al., Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells. J Immunol. 1991 Sep 1;147(5):1701-8
  • Latest
    J:298212 Abou-Samra E, et al., NKR-P1B expression in gut-associated innate lymphoid cells is required for the control of gastrointestinal tract infections. Cell Mol Immunol. 2019 Nov;16(11):868-877
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
04/09/2024
MGI 6.23 		The Jackson Laboratory