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Klrb1b Gene Detail
Summary
  • Symbol
    Klrb1b
  • Name
    killer cell lectin-like receptor subfamily B member 1B
  • Synonyms
    Klrb1d, Ly55b, Ly55d, Nkrp1-b, NKR-P1B, Nkrp1d, NKR-P1D
  • Feature Type
    protein coding gene
  • IDs
    MGI:107539
    NCBI Gene: 80782
  • Gene Overview
    MyGene.info: KLRB1
  • Alliance
Location &
Maps
more
  • Sequence Map
    Chr6:128813706-128826331 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.09 cM, cytoband F3
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    235 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107539
protein coding gene Chr6:128813706-128826375 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031335
protein coding gene Chr6:132467050-132480796 (-)
A/J MGP_AJ_G0031306
protein coding gene Chr6:127394226-127408976 (-)
AKR/J MGP_AKRJ_G0031234
protein coding gene Chr6:130843984-130858537 (-)
BALB/cJ MGP_BALBcJ_G0031313
protein coding gene Chr6:126986529-127000579 (-)
C3H/HeJ MGP_C3HHeJ_G0031037
protein coding gene Chr6:131028321-131046147 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031772
protein coding gene Chr6:135935973-135950338 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028918
protein coding gene Chr6:124713599-124728298 (-)
CAST/EiJ MGP_CASTEiJ_G0030417
protein coding gene Chr6:131234729-131247519 (-)
CBA/J MGP_CBAJ_G0030998
protein coding gene Chr6:141217565-141250104 (-)
DBA/2J MGP_DBA2J_G0031154
protein coding gene Chr6:126319300-126350805 (-)
FVB/NJ MGP_FVBNJ_G0031104
protein coding gene Chr6:125222718-125236233 (-)
LP/J MGP_LPJ_G0031236
protein coding gene Chr6:132643142-132663720 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031142
protein coding gene Chr6:145066886-145087633 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031805
protein coding gene Chr6:130870765-130884751 (-)
PWK/PhJ MGP_PWKPhJ_G0030132
protein coding gene Chr6:124544571-124601849 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029961
protein coding gene Chr6:128963082-128982270 (-)
WSB/EiJ MGP_WSBEiJ_G0030503
protein coding gene Chr6:131206543-131277439 (-)



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKRP1A, NKR-P1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9595274-9607901 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    4 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit abnormal NK cell phsyiology.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000079298 Ensembl Gene Model | MGI Sequence Detail 12626 C57BL/6J ±  kb
transcript ENSMUST00000032472 Ensembl | MGI Sequence Detail 2228 Not Applicable  
polypeptide ENSMUSP00000032472 Ensembl | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    8 Sequences
  • PDB
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
Molecular
Reagents
less
  • All nucleic 18
    Genomic 5
    cDNA 13

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-36109, MGI:1931428
References
more
  • Summaries
    All 35
    Gene Ontology 6
    Phenotypes 4
  • Earliest
    J:35067 Giorda R, et al., Mouse NKR-P1. A family of genes selectively coexpressed in adherent lymphokine-activated killer cells. J Immunol. 1991 Sep 1;147(5):1701-8
  • Latest
    J:241359 Aguilar OA, et al., A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell. 2017 Mar 23;169(1):58-71.e14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory