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Klrb1c Gene Detail
Summary
  • Symbol
    Klrb1c
  • Name
    killer cell lectin-like receptor subfamily B member 1C
  • Synonyms
    CD161, Ly55c, Ly59, Ly-59, Nk1, Nk-1, Nk1.1, NK-1.1, Nk-1.2, NK-RP1, NKR-P1, Nkrp1-c, NKR-P1C
  • Feature Type
    protein coding gene
  • IDs
    MGI:107538
    NCBI Gene: 17059
  • Gene Overview
    MyGene.info: KLRB1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:128778485-128788641 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 63.09 cM
  • Mapping Data
    26 experiments
Strain
Comparison
more
  • SNPs within 2kb
    145 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107538
protein coding gene Chr6:128778485-128789215 (-)
129S1/SvImJ no annotation
A/J MGP_AJ_G0031302
protein coding gene Chr6:127163384-127168920 (-)
AKR/J MGP_AKRJ_G0031233
protein coding gene Chr6:130784406-130804305 (-)
BALB/cJ no annotation
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031770
protein coding gene Chr6:135885856-135908533 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028915
protein coding gene Chr6:124672964-124681918 (-)
CAST/EiJ MGP_CASTEiJ_G0030416
protein coding gene Chr6:131195809-131207169 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0031152
protein coding gene Chr6:126259647-126290409 (-)
FVB/NJ MGP_FVBNJ_G0031102
protein coding gene Chr6:125163328-125194830 (-)
LP/J MGP_LPJ_G0031235
protein coding gene Chr6:132638653-132655107 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031141
protein coding gene Chr6:144993462-145022656 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031803
protein coding gene Chr6:130809508-130821757 (-)
PWK/PhJ MGP_PWKPhJ_G0030131
protein coding gene Chr6:124543069-124553195 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029960
protein coding gene Chr6:128889792-128897318 (+)
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    KLRB1, killer cell lectin like receptor B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD161, CLEC5B, hNKR-P1A, NKR, NKR-P1, NKRP1A, NKR-P1A
  • Links
    NCBI Gene ID: 3820
    neXtProt AC: NX_Q12918
    UniProt: Q12918

  • Chr Location
    12p13.31; chr12:9595274-9607901 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotype references
This locus controls an antigen on natural killer cells. The a allele determines the Nk1.1 antigen in strains CE, C57BL/6, C57BR/cd, C57L, C58, DBA/1, MA/My, NZB, SJL, SM and B10.D2. The b allele determines the Nk1.2 antigen in strains CBA/J, BALB/c, C3H/He, A/J, DBA/2, LP and 129.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17059 NCBI Gene Model | MGI Sequence Detail 10157 C57BL/6J ±  kb
transcript NM_001159904 RefSeq | MGI Sequence Detail 2641 C57BL/6  
polypeptide P27814 UniProt | EBI | MGI Sequence Detail 223 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR016187 C-type lectin fold
    IPR001304 C-type lectin-like
    IPR016186 C-type lectin-like/link domain superfamily
    IPR033992 Natural killer cell receptor-like, C-type lectin-like domain
Molecular
Reagents
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  • All nucleic 18
    Genomic 8
    cDNA 9
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-12001, MGD-MRK-12044, MGD-MRK-12881, MGD-MRK-12883, MGD-MRK-36108, MGI:2141422, MGI:96879, MGI:97344
References
more
  • Summaries
    All 93
    Developmental Gene Expression 1
    Gene Ontology 19
    Phenotypes 10
  • Earliest
    J:5742 Glimcher L, et al., Identification of a cell-surface antigen selectively expressed on the natural killer cell. J Exp Med. 1977 Jan 1;145(1):1-9
  • Latest
    J:241359 Aguilar OA, et al., A Viral Immunoevasin Controls Innate Immunity by Targeting the Prototypical Natural Killer Cell Receptor Family. Cell. 2017 Mar 23;169(1):58-71.e14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/30/2020
MGI 6.15
The Jackson Laboratory