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Evpl Gene Detail
Summary
  • Symbol
    Evpl
  • Name
    envoplakin
  • Synonyms
    210kDa protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:107507
    NCBI Gene: 14027
  • Gene Overview
    MyGene.info: EVPL
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116220559-116238077 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.02 cM, cytoband E1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    200 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_107507
protein coding gene Chr11:116220559-116238091 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019420
protein coding gene Chr11:120318483-120335986 (-)
A/J MGP_AJ_G0019389
protein coding gene Chr11:115060060-115078625 (-)
AKR/J MGP_AKRJ_G0019359
protein coding gene Chr11:118489447-118508240 (-)
BALB/cJ MGP_BALBcJ_G0019363
protein coding gene Chr11:115471618-115490044 (-)
C3H/HeJ MGP_C3HHeJ_G0019169
protein coding gene Chr11:118840879-118858816 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019813
protein coding gene Chr11:124006940-124024439 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017436
protein coding gene Chr11:112071742-112089320 (-)
CAST/EiJ MGP_CASTEiJ_G0018724
protein coding gene Chr11:120200991-120220213 (-)
CBA/J MGP_CBAJ_G0019141
protein coding gene Chr11:128894560-128912050 (-)
DBA/2J MGP_DBA2J_G0019252
protein coding gene Chr11:114476951-114494610 (-)
FVB/NJ MGP_FVBNJ_G0019244
protein coding gene Chr11:113990837-114008644 (-)
LP/J MGP_LPJ_G0019322
protein coding gene Chr11:120697660-120716848 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019277
protein coding gene Chr11:127978681-127996561 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019851
protein coding gene Chr11:119145681-119166198 (-)
PWK/PhJ MGP_PWKPhJ_G0018488
protein coding gene Chr11:115810341-115828916 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018281
protein coding gene Chr11:118901137-118918363 (-)
WSB/EiJ MGP_WSBEiJ_G0018776
protein coding gene Chr11:119117100-119134678 (-)



Homology
more
  • Human Ortholog
    EVPL, envoplakin
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EVPL, envoplakin
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EVPK
  • Links
    NCBI Gene ID: 2125
    neXtProt AC: NX_Q92817
    UniProt: Q92817

  • Chr Location
    17q25.1; chr17:76006845-76027452 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1506
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: EVPL
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted deletion of this gene are viable and fertile. Surprisingly, cornified envelope assembly is not inhibited and adult homozygotes show no obvious pathological phenotype in skin or other epithelia, despite a slight delay in barrier acquisition during embryonic development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000034282 Ensembl Gene Model | MGI Sequence Detail 17519 C57BL/6J ±  kb
transcript ENSMUST00000037007 Ensembl | MGI Sequence Detail 6384 Not Applicable  
polypeptide ENSMUSP00000037850 Ensembl | MGI Sequence Detail 2035 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 30
    Genomic 1
    cDNA 29

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-36077
References
more
  • Summaries
    All 31
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 6
  • Earliest
    J:34569 Ruhrberg C, et al., Envoplakin, a novel precursor of the cornified envelope that has homology to desmoplakin. J Cell Biol. 1996 Aug;134(3):715-29
  • Latest
    J:229913 Natsuga K, et al., Increased Bacterial Load and Expression of Antimicrobial Peptides in Skin of Barrier-Deficient Mice with Reduced Cancer Susceptibility. J Invest Dermatol. 2016 Jan;136(1):99-106

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory